HEMOPHILIA B.PHARM 2ND SEM PATHOPHYSIOLOGY.pptx

HAEMOPHILLIA,

1. HEMOPHILIA

2. INTRODUCTION Hemophilia is an inherited bleeding disorder in which there is a deficiency or lack of clotting factor VIII (hemophilia A) or factor IX (hemophilia B) or factor XI (hemophilia C), which causes fail to clot blood.

3. PATHOPHYSIOLOGY

4. PATHOPHYSIOLOGY Hemophilia  is an X-linked bleeding disorder caused by a deficiency or complete absence of coagulation factor VIII (hemophilia A) or factor IX (hemophilia B). Bleeding in hemophilia occurs due to the failure of secondary hemostasis (helps in activation of coagulation system)

5. TYPES There are two major types i.e. Type A and Type B. Beside these two type a minor type is found called Type C.

6. SYMPTOMS Blood in urine or stool. Nosebleeds without known cause, Bleeding into brain. Pain, swelling, tightness in joints. Unusual bleeding after vaccination.

7. COMPLICATIONS Deep internal bleeding. Damage to joints. Infection.

8. TREATMENT Treatment includes injections of a clotting factor or plasma.