iCMLf Forum at ASH: Introductory Presentation

Introductory Presentation of the "iCMLf Forum", hosted by the International CML Foundation for physicians from emerging countries during the ASH Annual Meeting

1. The 2011 iCMLf Forum
CML Management in
Emerging Economic Regions
Presented in partnership with
The Max Foundation
The 2011 iCMLf Virtual Education Program is supported by an unrestricted grant
from Novartis Oncology

2. iCMLf: Who are we?
•Established by a group of leading hematologists
•Founded & registered in 2009 as a charitable foundation
•Mission: to improve the outcomes for patients with CML globally
•Aims: Foster and coordinate global clinical and research collaborations
and to improve clinical practice and disease monitoring in CML
•Advisors: 34 countries from all continents including patient
group representation

3. The iCMLf Virtual Education Program
in partnership with
The Max Foundation
Increase access to CML knowledge and education through ‘at home’
learning
Including a dedicated annual
meeting to share experiences
and best practice in emerging
regions

4. iCMLf Virtual Education Program 2011
•Presentations from CML experts on the best practice
management of CML
•CML care in countries with limited access to monitoring
& treatment
•Webcasts hosted on the iCMLf website,
over 1,000 views per module
•USB drives for physicians without broadband Internet
•2011 Program: More languages, more modules
•CML management updates in French and Spanish
•The importance of molecular monitoring & BCR-ABL
kinase domain mutation analysis
•Stem Cell Transplantation in 2011

5. iCMLf Forum at ASH
•Emerging Regions Networking Meeting
at ASH - 2010
•150 attendees
•2011 – iCMLf Forum
“CML Management in Emerging Regions”
•Now an annual event
•A networking meeting with discussion on
the challenges and solutions of CML
treatment when resources are limited

6. The Emerging Regions Support and
Partnership (ERSAP) Program
Enhancing clinician’s knowledge, sharing best practice
and improving the access to diagnosis and testing
facilities in emerging economic regions
where this is most needed

7. ERSAP Preceptorship Program
Facilitate the sharing of best practice treatment between CML Centres of excellence and hematologists from
Emerging Regions
•Facilitate the sharing of best practice treatment between CML Centres of
excellence and hematologists from Emerging Regions
•Intensive 3-4 week preceptorships

•Preceptors are part of the clinical team
participating in seminars and laboratory
work where appropriate
•Preceptors come from all over the world

8. A successful first project
•2010
•20 Preceptorships at 5 CML centres of excellence:
•Positive Feedback
•Highly valued CML education, advancing knowledge of testing, increased overall
hematology knowledge, networking for future support
•2011
•26 Preceptorships at 8 CML centres of excellence
•Australia – Tim Hughes, France - Francois Mahon,
•Italy – Michele Baccarani, Spain - Juan Luis Steegmann,
•UK – Jane Apperley, UK - Richard Clark,
•USA – Jorge Cortes, USA – Michael Mauro
•2012
•Up to 30 preceptorships at 10 centres of excellence
•Open for applications www.cml-foundation.org

9. ERSAP Diagnosis and Testing Program
Increasing access to equipment and facilities to enhance the diagnosis and monitoring of CML patients
thus improving potential outcomes.
•Building partnerships to increase access to CML diagnostics in
emerging regions
•Facilitating sample shipments to reference laboratories
•Increasing capacity for local CML monitoring providing equipment,
training and resources under the mentorship of CML centres of
excellence

10. 1) Through iCMLf funding and support
•iCMLf grants to increase capacity to diagnose and monitor CML patients
•Program open for centres in emerging regions
•Grants awarded on evaluation of submitted proposals
•Grants up to US $10,000 along with additional support from a partnering CML
centre of excellence
•Grants have been awarded to centres in Ghana, India, Indonesia, Kenya, Nepal,
Nigeria and Uzbekistan
•Centres have the flexibility to run the program according to their local
situation with the ongoing support of a CML centre of excellence

11. 2) Through iCMLf expert resources and long term
partnerships
•Blood screening across the pacific
•An example of sample shipment to increase access to diagnosis
and monitoring
•In September 2010 8 iCMLf advisors offered free PCR testing
•In July 2011 we had the the first opportunity to make use of this
•TMF approached us to help a patient in the Philippines
•1 patient developed to 30
•Developing a long term partnership between Adelaide and
Philippine General Hospital

12. 3) Through iCMLf education and technical expertise
•iCMLf / MAX Diagnostic Project, Cepheid GeneXpert instrument
•Rapid molecular testing capability, across multiple diseases
•Goal: to utilize TB instruments in place in key countries to provide a diagnostic
solution in resource poor countries
•Project Status:
Identified 6 priority countries (Ethiopia, Tanzania, Uzbekistan, Honduras, Nepal and El Salvador)
Existing instruments in Ethiopia and Uzbekistan, limited cartridges for both sites
Training Ethiopian physician in Adelaide during ERSAP Preceptorship and Uzbekistan physician
in October through iCMLf diagnostics grant
•Project launched in Ethiopia October 6 and Uzbekistan October 26
“No more blind treatment
of CML patients”
Dr Gebremedhin
Ethiopia

13. The iCMLf Online www.cml-foundation.org
Providing wide access to CML expertise, knowledge and support for clinicians around the world
1.Difficult Cases in CML - Online discussion forum
• interested clinicians discuss difficult or interesting CML patient cases
2.CML Scientific News Section
•Current CML articles submitted by iCMLf members
3.Pediatric CML Community
•Activities include:
•Online access to current data and publications
•Regular teleconferences discussing Pediatric CML cases
•Opportunities for collaboration and data sharing

14. Join CML patients
worldwide to celebrate

15. International Chronic Myeloid Leukemia
Foundation
Improving the outcomes for patients with CML globally
www.cml-foundation.org