Innovations in pharmaceutical industry

Innovations in pharmaceutical industry, pharmaceutical industry, new tech, innovations, new medicines, future of medicine,technology, fda, 3d printing

1. INNOVATIONS IN PHARMACEUTICAL INDUSTRY

2. INNOVATION Defined as the idea which must be replicable at an economic cost and must satisfy specific need. Involves applications of information, imagination and initiative in deriving greater or different values from resources. It includes all processes by which new idea generated and converted into useful products.

3. 3D PRINTING What is 3D Printing of Drugs? Three-dimensional (3D) printing of drugs uses computer-aided designs to manufacture individualized pharmaceutical drug products. The USFDA approved an epilepsy medicine called spritam introduced by Aprecia pharmaceutical company . TECHNOLOGY: - Inkjet based fabrication Direct-write ZipDose ® Thermal Inkjet printing Stereolithography (SLA) Fused deposit modeling (FDM).

4. ZIPDOSE TECHNIQUE:-

5. What is the Purpose of 3D Printing of Pharmaceuticals ? To develop medications with controlled release of drugs & fixed-dose combinations. 3D bio-printed human models, tissues or organs are being used in oncology therapy to develop newer anti-cancer drugs. Use of these models would help formulate anti-cancer drugs quickly. Advantages:- Small batches can be manufactured Hospitals could manufacture small batches on-demand, eliminating the need to maintain an extensive inventory of generic formulations There is no need to provide extended shelf life for a product

6. mHealth Sensors mHealth sensors are used in the practice of medicine supported by mobile devices. Can be monitored with the health and physiological data without visiting doctor. Patient-compliance is more. World’s first Virtual Care Center– Mercy Virtual Center

7. Organ-on-chip Technology Emulate developed organ-on-chip technology, which has created a new living system that emulates a human biology. It has been done to understand the diseases, medicines, and food affect the human health. The main motive to develop this technology is to provide more predictive and useful measures of safety and efficacy of new drug or drug combination and also to reduce use of animals and humans in testing. Company has developed working models on liver, lung, intestine and brain.

8. Translucent polymer chip models, about the size of a AA battery, could provide drug candidate safety data with greater speed and accuracy. On 11 April 2017 FDA Signs Collaborative Agreement with Emulate, to Use Organs-on-Chips Technology as a Toxicology Testing Platform for Understanding How Products Affect Human Health and Safety. In human chip, we simply recreate the environment required for the particular organ .

9. Design of different organ chips

10. MALACIDINS New class of antibiotic discovered in Rockefeller University, New York Used DNA information that encodes production of antibiotic in daptomycin Active against multidrug – resistant pathogens , Staphylococcus aureus (MRSA) skin infections

11. Culture Independent Strategy: Figure: Using a culture – independent strategy for the discovery of malacidins from the global microbiome

12. TruMedicine Drug and pill packet tracking app Pattern Image Recognition Tru Medicines uses advanced Image Edge Neural Network processing to identify Billions of registered pill images. Method protected by U.S. and International Patents. FDA Guidance   2011 Oct FDA guidance recommends the use of colored excipients for identification and prevention of counterfeiting. High Speed Cameras   To verify quality of pills and capsules in 2,500 production lines. 360 degree photos 2,000/min.,  100%inspection , images uploaded to cloud databases

13. Opioid Treatment Tracking Compliance with drug treatment programs can monitor hundreds of patients at a fraction of the cost of traditional 30 day in-service treatment programs. Stops Relapse Deep pill open Source API TruMedicines open source API interface allows 3rd party developers to integrate image recognition into hardware; Pill Packaging, Smart Pill dispensers, etc.

14. References https://www.omicsonline.org/open-access/3d-printing-technology-in- http://www.rroij.com https://mhealthintelligence.com Straus, S.K. & Hancock, R.E. Mode of action of the new antibiotic for Gram positive pathogens daptomycin . Biochim . Biophys . Acta 1758 , 1215-1223 (2006). https://www.nature.com/articles/s41564-018-0110-1