Introduction To Herbal Formulations

Hi Friends , This ppt contains some information related to herbal formulation .This topic mainly abstracted from Pharmacognosy subject of FY.D.pharmacy.so i hope you like my slide and if you like my slide then like ,share and follow me.

1. INTRODUCTION TO HERBAL FORMULATIONS Subject:- Pharmacognosy Prepared by : Mr. Amit Chaudhari Asst. Professor, MIP Dhanore ( M .PHARM ) MATOSHRI INSTITUTE OF PHARMACY, DHANORE (YEOLA) , A.Y. 2021-22 1

2. INTRODUCTION Herbal Medicine has been used for thousands of years; in fact, its history goes back much further than that of today’s pharmaceuticals. It is a major component of alternative medicine, and is useful in preventing and treating a number of common ailments. Nature’s pharmacy is extensive, filled with herbs that possess powerful medicinal properties with guidance and knowledge ,everyone has the ability to use herbs to ease discomfort and promote healing. 2

3. HERBAL DRUGS According to WHO the herbal drugs are defined as Finished , labelled medicinal products that contains as active ingredients aerial or underground parts of plants or other plant material or combination thereof whether in the crude state or as plant preparations. Advantages Of herbal Medicine More Closely related to our body structure because we are composer of nature. Do not alter hormone balance change chemical levels in the brain or tricks your body. Disadvantages of herbal Medicine Would not be able to treat serious trauma such as broken legs Would not able to heal appendicitis or a heart attack as effectively as conventional drugs would use modern diagnostic test , surgery and drugs. 3

4. CONVENTIONAL DRUGS It means either (a) Pharmacological single entities which have been derived by chemical synthesis – the so called new to nature drugs or (b) single chemical derivatives of naturally occurring pharmacologically active substances detected in and isolated from members of plants, fungus, bacterial or animal world. Advantages of conventional medicine Provides full attention to the patients as the doctor or therapist is able to fully dedicate himself or herself to the patients and it helps in the healings process. There exist many conditions that indispensably require conventional treatment Disadvantages of conventional medicine Many side effects that seem to sometimes harm patients more than it helps them May be hard to afford ,rising cost These drugs are made in labs, rather than by nature , they are given a stamp of approval even when their side effects may harm people 4

5. Efficacy of herbal medicine products Herbal medicine usually contains a range of pharmacologically active compounds in some cases it is not known which ingredients are important for the therapeutic effect. Many herbalists believe that isolated ingredients have weaker clinical effects than whole plant extracts ,a notion that would obviously require proof in each case. Given these caveats clinical trials of herbal medicines are feasible much in the same way as for other drugs .numerous randomized clinical trials of herbal medicines have been published and . Systematic reviews /meta –analyses of these studies have become available 5

6. VALIDATION OF HERBAL THERAPIES Herbal medicines attracts the interest of both patients and scientists, in all aspects of drug developments from natural products and also for validation of traditional medicine (TM).Several developing countries rely on TM because of their accessibility and affordability and scientists all over the world consider medicinal plants as a source of new chemical entities and use them to isolate compounds such as digoxin, morphine, taxol , atropine and vinblastine. Quality issues of medicines can be classified into two categories (external and internal) 1)External issues include toxic metals, Pesticides residues, microbes, adulteration and misidentification of medicinal plants. 2) The internal issues affecting the quality of herbal medicines are complexity and non-uniformity of the ingredients. Through the use of modern analytical methods and pharmaceutical technique, previously unsolved internal issues have become solvable. Proper methodologies for the research and development, manufacturing and quality control of the formulation in TM and investigations of the therapeutic potentials of plants used in those systems with support of scientific methods may help to use them with maximum possible efficacy. 6

7. DEVELOPMENT OF HERBAL MEDICINE The international trade in herbal medicine has attracted most of the pharmaceutical companies, including the multinationals. Currently, several large multinational companies are interested in commercializing herbal drugs. Integrated approaches in botanical research are shown in below figure.1 7

8. Fig.2 Integrated approaches for development of Traditional medicine (Herbal medicine) 8

9. ISSUES FOR QUALITY CONTROL AND QUALITY ASSURANCE OF HERBAL MEDICINE QC and QA of herbal medicines are very important to protect the integrity of the herbal extracts / products for the management of pharmaceutical quality . They have an important role for the reproducibility of the effect of the active ingredients from batch to batch uniformity. To maintain and comply with the standard conditions with respect to quality, safety and efficacy of herbal medicine it is required to follow some important steps for standardization. This includes the following step: Proper authentication and taxonomic assignment, such as through DNA fingerprinting and DNA bar coding. Structural elucidation of all isolated compounds of the medicinal plants. Identification and characterization of the bioactive constituents for the pharmacological activity. Standardization of the single extracts through spectroscopic analysis in the multicompound extracts. International harmonization of specific standardization process under the umbrella of the International F ederation of Pharmaceutical M anufacturers Associations (IFPMA) 9

10. 10