Kegg database resources

Sarfaraz Nasri Department of bioinformatics and Biotechnology

1. SARFARAZ NASRI GC university Faisalabad [email protected]

2. Presented to: Dr. Rizwan Department of Bioinformatics & Biotechnology Gcuf

3. Introduction: Kyoto Encyclopedia of Genes and Genomes(KEGG): “It is a collection of online databases dealing with genomes, enzymatic pathways, and biological chemicals.” Pathway database Record networks of molecule interaction

4. Computerize current knowledge of biological systems & provide consistent annotations. Maintain gene catalogs for sequenced genomes. Maintain catalogs of chemical reactions in living cells by LIGAND. Provide new informatics technologies toward predicting biological systems and designing further expriments . Objectives:

5. Database of KEGG KEGG maintain 6 main databases: KEGG Pathway(Atlas) KEGG Genes KEGG Genome KEGG Ligand KEGG BRITE KEGG Cancer

6. KEGG Pathway “KEGG PATHWAY is a collection of manually drawn pathway maps representing our knowledge on the molecular interaction and reaction networks for:” Metabolism Genetic Information Processing Environmental Information Processing Cellular Processes Organismal Systems Human Diseases Drug Development

7. KEGG: metabolic pathway

8. KEGG GENES: Collection of gene catalogs for all complete genomes Four types: MGENES (Meta Genomes) VGENES (Viral Genome) DGENES (Draft Genome) EGENES (EST datasets)

9. KEGG GENOME Collection of KEGG organisms which are the organisms with known complete genome sequence.

10. KEGG Ligand:

11. KEGG BRITE: Collection of manually created hierarchical text files capturing functional hierarchies of various of biological objects, especially those represented as  kegg object.

12. KEGG CANCER:

13. Applications : Use to detect functionally related enzyme clusters. Automatic detection of conserved gene clusters in multiple genomes by graph comparison . Modeling & Stimulation Browsing and retrieval of data

14. Conclusion: The Kyoto Encyclopedia of Genes and Genomes is a vast library of information gathered from fully sequenced genomes, genes, proteins, pathways, and chemical compounds pertaining to over a hundred different species of both prokaryotes and eukaryotes .