liquid dosage forms (syrups, suspensions).pptx

ppt

1. Dr . Muhannad Al- Rabaty 2 nd Lab

2. “Syrups are concentrated aqueous preparations of a sugar or sugar substitute with or without flavoring agents and medicinal substances.”

3. Simple syrup Medicated syrups Non-medicated syrups

4. A simple syrup contains only sucrose and purified water (e.g. Syrup USP). Saturated sugar solution without flavor or medicine.

5. “Syrups containing flavoring agents but not medicinal substances are called non-medicated or flavored syrups”

6. Syrups containing therapeutic agent (API) are called medicated Syrups.

7. Functions of sucrose or its derivatives: Viscosity Sweetness Flavoring agent Masking bitter taste.

8. Most syrups contain a high proportion of sucrose, usually 60% to 80% not only because of desirable sweetness and viscosity of such solutions

9. The amount of a preservative required to protect a syrup against microbial growth varies with the proportion of water available for microbial growth and capability of preservative itself . Most commonly used preservative: Benzoic acid Sodium benzoate

10. Most syrups are flavored with:- 1. Naturally occurring materials: Volatile oils i.e. Orange oil. Synthetic flavorants: Vanillin and others. 2. Purpose and benefits of flavorant To render the syrup pleasant taste .

11. To enhance the appeal of the syrup , a coloring agent that correlate with the flavorant employed is used iv.

12. Preparation of Syrups

13. Syrups are frequently prepared by : solution of the ingredients with the aid of heat, solution of the ingredients by agitation without the use of heat . addition of sucrose to a prepared medicated liquid or to a flavored liquid,

14. Appropriate for any patient, whatever the age is.

15. Economical and safe to the patient The liquid dosage form is expected for certain types of products like cough medicines.

16. Difference between Syrups And Elixirs: Syrups Elixirs Alcohol is not necessary component more sweet than elixir 3.more viscous than elixirs 4.High concentration of sugar 5.Less Stable 6.Difficult to formulate than elixirs 7.More effecting in masking the taste of medicinal agents 8.May not be clear formulations 9.Sucrose Syrup can not be used for diabetic patient but if used exercise care. Alcohol is necessary component Less sweet than syrup 3.Less viscous than syrup 4.Less proportion of sugar 5.More stable 6.Easy to formulate than syrups 7.Less effecting in masking the taste of medicinal agents 8.These are clear formulations 9.Can be used for Diabetic patients easily