Introduction Circulatory system consist of: CVS Lymphatic system
Network of organs, collection of tissues and lymphatic vessels
Tissue drainage (3-4 L/day) Absorption in the small intestine Immunity
Interstitial/Tissue fluid - around all body tissues Some fluid return to capillaries Remainder diffuses through more permeable walls of lymph capillaries and becomes lymph
Lymphatic system
Components are: Lymph Lymphatic vessels Lymph nodes Lymphatic organs: Spleen and thymus Diffuse lymphoid tissue eg . Tonsils Bone marrow
Lymph and Lymphatic vessels
Lymph Clear, colorless watery fluid Transports plasma proteins that seep out of capillary beds back to bloodstream Also carries away larger particles, e.g. bacteria and cell debris from damaged tissues Filtered out and destroyed by lymph nodes Contains lymphocytes
Lymphatic capillaries Originate as blind-end tubes in interstitial spaces Same structure as blood capillaries Join up to form larger lymph vessels Exceptions : Central nervous system Cornea of the eye Bone and bone marrow Most superficial layers of skin Cartilage
Lymphatic vessels Found running alongside arteries and veins Walls have same 3 layers Cup-shaped valves
Lymphatic vessels
Become larger as they join together : Lymphatic trunks Thoracic duct and right lymphatic duct Empty lymph into subclavian veins
Thoracic duct Begins at cisterna chyli (L1-L2) 40 cm long Opens into left subclavian vein Drains lymph from both legs, the pelvic and abdominal cavities , the left half of the thorax, head and neck and the left arm
Right lymphatic duct A dilated lymph vessel about 1 cm long Opens into right subclavian vein Drains lymph from the right half of the thorax, head and neck and the right arm
Lymphatic vessels
Lymphatic Cells
NK cells Lymphocytes B-Lymphocytes T-Lymphocytes Macrophages Dendritic cells
Lymphatic Tissues
Aggregations of lymphocytes in connective tissues of mucus membranes and various organs Simplest form - Diffuse lymphatic tissue Particularly prevalent in body passages that are open to the exterior— respiratory, digestive, urinary, and reproductive tracts— MALT
In some places, dense masses - lymphatic nodules (follicles) Lymph nodes, tonsils, and appendix In the ileum - Peyer patches
Lymphatic (Lymphoid) Organs
Well-defined anatomical sites Connective tissue capsules Include: Red bone marrow Thymus Lymph nodes Spleen
Red Bone Marrow Soft, loosely organized, highly vascular material Hemopoiesis and immunity Important supplier of lymphocytes
Lymph node Oval or bean-shaped Most numerous lymphatic organs Along the length of lymph vessels – in groups Vary in size
Structure Capsule : fibrous connective tissue Reticular tissue : support Lymphatic tissue : immunity Many afferent vessels, usually only one efferent vessel 31