Membrane Physiology, Nerve and Muscle.pptx

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1. Membrane Physiology, Nerve and Muscle Genesis of Resting membrane potential

2. Quick Revision Cell membrane Electrochemical gradient Gibbs- Donan Equilibrium Nernst equation Goldman-Hodgkin-Katz equation Measuring membrane potentials

3. Resting membrane potential of a neuron Resting membrane potential of a neuron = -90mV How this Resting membrane potential is generated? Sodium-Potassium pump Potassium “leak” channels Guyton And Hall Textbook Of Medical Physiology, 14 th Edition

4. Origin of Resting Membrane Potential NERNST EQUATION: Resting Membrane Potential = Equilibrium potential of K+ = -94 mV Guyton And Hall Textbook Of Medical Physiology, 14 th Edition

5. Origin of Resting Membrane Potential GOLDMAN-HODGKIN-KATZ EQUATION: Resting Membrane Potential = (-94 mV +8 mV) = -86 mV Guyton And Hall Textbook Of Medical Physiology, 14 th Edition

6. + + + + + + + + + + + + + + + + + + + Origin of Resting Membrane Potential 2 K+ 3 Na+ Resting Membrane Potential = (-94 mV +8 mV -4 mV) = -90 mV Guyton And Hall Textbook Of Medical Physiology, 14 th Edition

7. Genesis of an Action Potential Phases of an Action Potential Cellular mechanisms Next class

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