Mnemonics biochemistry 1

Mnemonics biochemistry

1.  Glucogenic amino acids
"HAVe Money"
His
Arg
Val
Met
 Glucogenic/ketogenic amino acids
"TTIP"
Thr
Trp
Phe
Ile
 Ketogenic amino acids
"LL"
Lys
Leu
 Amino acids w/ 3 titratable protons
"Acidic, Basic, Cys, Tyr"
Acidic = Asp, Glu
Basic = Arg, Lys, His
 Dibasic amino acids
"COAL"
Cys
Orn
Arg
Lys
 Urea cycle
"Ordinarily, Careless Crappers Are Also Frivolous About Urination"
Ornithine + Carbamoyl Phosphate → Citrulline...+Aspartate → Arginosuccinate → Fumarate +
Arginine → Urea
 NADH production in TCA
"KIM likes goNADs"
After...
α-ketoglutarate
Isocitrate
Malate
 TCA cycles
"Can I Keep Selling Sex For Money, Officer?"
Citrate
Isocitrate
α-KG
Succinate
Succinyl-CoA
Fumarate

2. Malate
Oxaloacetate
 Blotting procedures
"SNoW DRoP"
Southern = DNA
Northern = RNA
Western = Protein
SouthWestern= DNA-binding Proteins
 X-linked Recessive Disorders
"Be Wise, Fool's GOLD Heeds Silly Hope, Alport"

Bruton's agammaglobulinemia
Wiskott-Aldrich Syndrome
Fabry's Disease
G6PD deficiency
Ocular albinism/Ornithine transcaramylase deficiency
Lesch-Nyhan Syndrome
Duchenne's and Becker's muscular dystrophy
Hunter's Syndrome
Hemophilia A and B
Alport syndrome
 Trinucleotide repeat expansion diseases
"X-Girlfirend's First Aid Helped Ace My Test"
Fragile X = CGG (chrX)
Freidrich's ataxia = GAA (chr9)
Huntington's = CAG (chr4)
Myotonic dystrophy = CTG (chr 19)
 22q11 deletion syndromes
"CATCH 22"
Cleft palate
Abnormal facies
Thymic aplasia
Cardiac defects
Hypocalemia (2° to PTH aplasia)
22q11

*CAC = velocardialfacial syndrome
*TCH = DiGeorge syndrome
 Reactions requiring VitB1
"Vitamin B1 helps make ATP"
Branched-chain AA dehydrogenase
α-ketoglutarate dehydrogenase (TCA)
Transketolase (HMP shunt)
Pyruvate dehydrogenase (glycolysis)
 Reactions requiring biotin

3. "PAP carboxylation"
Pyruvate carboxylase (gluconeogenesis via oxaloacetate)
Acetyl-CoA carboxylase (FA synthesis via malonyl-CoA)
Propionyl-CoA carboxylase (odd-chain FA & branched AA to TCA via methylmalonyl-CoA)
 Metabolic processes occurring in both cytosol & mitochondria
"HUGs take 2"
Heme synthesis
Urea cycle
Gluconeogenesis
 Infant deprivation effects
4 W's: "Weak, Wordless, Wanting, Wary"
Weak: weight loss, ↓muscle tone, physical illness
Wordless: poor language skills
Wanting: anaclitic depression, poor socialization
Wary: no basic trust

 Manic episode
"DIGFAST" (≥3)
Distractibility
Irresponsible behavior
Grandiosity
Flight of ideas
Agitation/↑Activity
↓Sleep
Talkativeness/pressured speech
 Major depressive disorder
"DSIGECAPS" (≥5, one of which must be anhedonia or depressed mood)
Depressed mood
Sleep disturbances
↓Interest (anhedonia)
Guilt/feelings or worthlessness
↓Energy
↓Concentration
↓Appetite/weight changes
Psychomotor retardation or agitation
Suicidal ideations
 Risk factors for suicide completion
"SAD PERSONS"
Sex (male)
Age (teenager, elderly)
Depression
Previous attempts
EtOH
iRRational thinking
Sickness

4. Organized plan
No spouse
(lack of) Social support
 Panic disorder
"PPANIICS"
Palpitations, Paresthesias
Abdominal distress
Nausea
Intense fear of dying/losing control, lIight headeedness
Chills, choking, disConnectedness
Sweating, Shaking, SOB
 Personality disorders
"Weird, Wild, Worried"
Cluster A = paranoid, schizoid, schizotypal
Cluster B = antisocial, borderline, histrionic, narcissitic
Cluster C = avoidant, obsessive-compulsive, dependent
 Cluster A personality disorders
"Weird: Accusatory, Aloof, Awkward"
Paranoid = accusatory
Schizoid = alood
Schizotypal = awkward
 Cluster C personality disorders
"Worried: Cowardly, Compulsive, Clingy"
Avoidant = cowardly
Compulsive = obsessive-compulsive
Dependent = clingy
 X-linked recessive disorders
"Be Wise, Fool's GOLD Heeds Silly Hope"
Bruton's agammaglobulinemia
Wiskott-Aldrich syndrome
Fabry's disase
G6PD deficiency
OTC deficiency/Ocular albinism
Lesch-Nyhan syndrome
Duchenne's & Becker's muscular dystrophy
Hunter's Syndrome
Hemophilia A & B
 WBC prevalence
"Neutrophils like making everything better"
Neutrophils = 40-60%
Lymphocytes = 20-40%
Monocytes = 2-8%
Eosinophils = 1-4%
Basophils 0.5-1%