Monobactam antibiotics

Monobactam Antibiotics
Introduction
Spectrum of activity
Pharmacokinetics
Pharmacodynamics
Clinical Uses
Adverse Effect

1. MONOBACTAM 1

2. Presented by Hina I shtiaq 2

3. CONTENT Monobactam Antibiotics Introduction Spectrum of activity Pharmacokinetics Pharmacodynamics Clinical Uses Adverse Effects 3

4. introduction M onocyclic β - lactam ring. Unique – β - lactam ring is not fused to another ring. Drug included in this class: Aztreonam - Chromobacterium violaceum Only monobactam available in USA. Structural similarity to ceftazidime . Spectrum of activity is similar to 3 rd generation cephalosporins . 4

5. Spectrum of activity Limited to aerobic gram negative rods Excellent activity against Enterobacteriaceae Pseudomonas aeruginosa No activity against gram positive bacteria or anaerobes Narrow spectrum precludes its use in emperic therapy 5

6. pharmacokinetics Route of administration – IV or IM Absorption: Poor oral absorption Rapid and complete absorption after IM injection Distribution: Penetrate well into cerebrospinal fluid Metabolism: Not extensive metabolism Biotransformation product is obtained from hydrolytic opening of β - lactam ring Elimination: Mostly unaltered excreted Elimination half life = 1.7 hours 6

7. Pharmacodynamics Bactericidal activity 7

8. Clinical uses Safe in patients unable to tolerate penicillin or cephalosporin Pneumonia Hospital acquired Pneumonia Meningitis Gram negative sepsis Urinary tract infections Osteomylitis 8

9. Adverse effects S kin rashes Elevation of serum aminotransferases Occasionally Abnormal liver function test 9

10. references Basic and Clinical Pharmacology by Bertram G. Katzung Lippincott's Pharmacology Manual of Pharmacology And Therapeutics by Goodman & Gillman http:// medind.nic.in/ibv/t04/i4/ibvt04i4p359.pdf http://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=& term=Aztreonam&field=entry#TreeD02.065.589.099.500.044 http://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=& term=Monobactams http://www.ncbi.nlm.nih.gov/pmc/articles/PMC185331/? page=4 10

11. Any question???? 11