Monoclonal antibody

Monoclonal antibody
# Definition
# A general representation of the method used to produce monoclonal antibodies
#Applications​
# Monoclonal antibodies for cancer.
#MAbs​ approved by the FDA for cancer include:
# Factor affecting monoclonal antibody immunogenicity
#Monoclonal​ Antibodies : 4 Types
# Monoclonal Antibodies : 4 Types images

1. Monoclonal antibody Presented By: Khushbu’s Microbiology

2. Monoclonal antibody   mAb  or  moAb : is an antibody made by  cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell .

3. A general representation of the method used to produce monoclonal antibodies

4. Applications Diagnostic tests Analytic & chemical uses Therapeutic use Cancer treatment

5. Monoclonal antibodies for cancer.   ADEPT , antibody directed enzyme prodrug therapy ;   ADCC: antibody dependent cell-mediated cytotoxicity; CDC: complement-dependent cytotoxicity, MAb : monoclonal antibody; scFv , single-chain Fv fragment .

6. MAbs approved by the FDA for cancer include : Alemtuzumab Bevacizumab Cetuximab Gemtuzuma ozogamicinb Ipilimumab Ofatumumab   Panitumumab Pembrolizumab Ranibizumab Rituximab Trastuzumab

7. Monoclonal Antibodies : 4 Types Murine : purely obtained from mice can cause human anti mouse antibodies (HAMA) to name its ending “momab” (ibritumomab). Chimeric : combined Fc human antibodies and Fab monoclonal antibodies mice, the sling name “ximab” (rituximab ). Humanized : only a small fraction of Fab mouse antibodies combine with human antibodies (95-98%) the sling name is “zumab” (trastuzumab ). Fully human, the whole human antibody, the sling names “ mumab ” (adalimumab).

8. Monoclonal Antibodies : 4 Types