MRI artifacts

This presentation overviews the common artifacts encountered during MR imaging and presents remedy for them.

1. Sudil Paudyal (51) BSc.MIT Final year ARTIFACTS IN MRI

2. 4/23/2013 MRI artifacts-sudil 2

3. Image Artifact ( brit . Artefact ) is something observed in a scientific investigation that is not naturally present but occurs as a result of the investigative procedure. (oxford dictionary) A structure not normally present, but visible as a result of malfunction in the hardware or software of the device, or a consequence of environmental influences as heat or humidity or can be caused by the human body itself. 4/23/2013 MRI artifacts-sudil 3 Introduction

4. All MRI images have artifacts to some degree. Some are irreversible and may only be reduced while others can be totally eliminated. Knowledge of artifacts a must for technologists to maintain optimum image quality. Causes should be understood and compensated for if possible to avoid being misjudged as pathology. Classified as to their basic principles, Physiologic (motion, flow) Hardware (electromagnetic spikes, ringing) Inherent physics (chemical shift, susceptibility, metal) 4/23/2013 MRI artifacts-sudil 4

5. Artifacts caused by pt. motion Ghosting and smearing: Most common artifacts produced by motion of pt.(voluntary / involuntary) From oesophageal contraction and vascular pulsation during head and neck imaging, From respiration and cardiac activity during thoracic and abdominal imaging, From bowel peristalsis during abdominal and pelvic imaging. Occurs when there is magnitude and/or phase deviation from optimal k-space encoding. 4/23/2013 MRI artifacts-sudil 5

6. Magnitude error - when a signal producing voxel changes position during application of RF pulse. Phase errors - Patient motion whenever a transverse component of magnetization exists and motion is perp. to the applied magnetic field Bo. 4/23/2013 MRI artifacts-sudil 6

7. Appearance of ghosting on final clinical image depends on where in k-space such phase errors occur: If along the x-axis of k-space : frequency encoding direction If along y-axis : phase encoding direction If in middle of k-space : smearing appearance If phase errors are periodic (as in pulsatile motion), periodic ghosting. Relatively more common in the phase encoding direction. 4/23/2013 MRI artifacts-sudil 7

8. Remedy Total elimination impossible unless imaging a cadaver!!!! Various methods Variants of rectilinear k-space filling techniques Fast spin echo Multisection imaging Single shot single section imaging techniques Parallel imaging Radial k-space filling techniques Cardiac gating and triggering Respiratory gating Navigator echo 4/23/2013 MRI artifacts-sudil 8

9. a) Variants of rectilinear k-space filling techniques CSE : dominant because of relative insensitivity to field inhomogeneity . FSE /TSE : reduction in TA 4/23/2013 MRI artifacts-sudil 9

10. Multisection imaging Several interleaved sections are imaged simultaneously Helps further decrease acquisition time Single shot single section imaging Sequences such as the HASTE are more resistant to motion Allow more rapid acquisition by filling only half of k-space. 4/23/2013 MRI artifacts-sudil 10

11. Parallel imaging : involves filling of selected lines in k-space at a predetermined interval. Requires use of multichannel, multicoil technology, with each coil possessing a distinct, known sensitivity profile over the FOV and with at least two coils placed in the phase encoding direction. The no. of phase encoding steps can be reduced by a factor of 1/X, where X is the parallel imaging factor (2 or 3). Thus image acquisition proceed X times faster by filling only one of every X lines(2nd or 3rd ) of k-space in phase encoding direction and by known coil sensitivity profiles to synthesize other lines. Eg : GRAPPA ( siemens ), SENSE ( philips ), SMASH 4/23/2013 MRI artifacts-sudil 11

12. 4/23/2013 MRI artifacts-sudil 12

13. b) Radial k-space filling techniques Standard line by line filling of k-space replaced by radial k-space filling with the use of a multishot radial acquisition technique ( eg . syngoBLADE , Siemens healthcare; PROPELLER, GE healthcare) MR imaging datasets acquired in multiple overlapping radial sections, each of which includes data sampled from the center to the periphery of k- space. A series of low resolution images is first reconstructed from each radial section and combined to produce a high resolution image. As the phase encoding direction varies with each radial section, ghosting is not propagated in PE direction but is dispersed throughout radial sections and thus has a lesser effect on final image. Also provide correction for in-plane rotation and bulk translational movement. 4/23/2013 MRI artifacts-sudil 13

14. 4/23/2013 MRI artifacts-sudil 14

15. c) Cardiac gating and triggering Cardiac motion periodic, both static and cine images Cine imaging performed by using a balanced SSFP that produces tissue contrast based on ratio of T1 to T2 , lending blood a high signal intensity (so called bright blood imaging). Cine imaging performed with retrospective cardiac gating i.e. a series of MR images of a single anatomic section are acquired during cardiac cycle, monitored with ECG . Data within k-space are linked with specific time point in cardiac cycle. The acquired datasets are then sorted acc to time stamp to produce sequential images allowing a dynamic evaluation of myocardial function. 4/23/2013 MRI artifacts-sudil 15

16. For static images to evaluate cardiac structure and not cardiac func ., prospective triggering is used and image acquisition is usually timed to occur during the end diastole. In triggering a certain no. of k-space lines is acquired during pt. breath holding for a given heartbeat. 4/23/2013 MRI artifacts-sudil 16

17. d) Respiratory gating Infrequently used in clinical imaging as compared to cardiac gating. Breath holding method most often used, but may not be feasible for infants, children, and pt.s with respiratory or cognitive impairment. Sequences with short acquisition time may be used, or if breath holding possible for limited time, exam may be divided into several brief acquisitions. If none is possible, respiratory gating. in which respiration related motion is monitored, using bellows or breathing belt, image acquisition is timed to take place at end expiration, when there is little or no motion. Phase reordering with either COPE or ROPE. 4/23/2013 MRI artifacts-sudil 17

18. e) Navigator echo Most commonly used in abdominal imaging at the interface of lung and diaphragm Application of small, one dimensional spatial encoding gradient in a plane perpendicular to diaphragm. Echo measured at this location allows correction of imaging dataset to ensure that, only the imaging data acquired, when diaphragm is at its peak (end expiration), are used in image reconstruction. 4/23/2013 MRI artifacts-sudil 18

19. Motion artifact contd.. 2. Pulsatile flow-related artifacts Periodic pulsation of vascular structures leads to ghosting in phase encoding direction at constant intervals. Distance between ghosts depends on diff. between heart rate and TR ; if synched, no ghosting. Macroscopic motion eg . Blood in large vessels or CSF in spinal canal also contribute to ghosting. 4/23/2013 MRI artifacts-sudil 19

20. Remedy a) ECG gating : time consuming, seldom used except for cardiac imaging b) Gradient moment nulling : Application of additional gradient pulses to correct for phase shifts among a population of moving protons at the time of echo collection. Corrects for constant-velocity motion and helps reduce the signal loss and ghosting associated with such movement. 4/23/2013 MRI artifacts-sudil 20

21. c) Saturation pulse: Additional RF pulses applied before the sequence in a plane perpendicular or parallel to imaging plane As applied at the beginning of sequence, their use may reduce the no. of imaging secitons that can be obtained per TR in multisection acquisitions. Also when SAR is already high, use of saturation pulse may result in excessive heat deposition. 4/23/2013 MRI artifacts-sudil 21

22. Artifacts caused by field distortions 1. Eddy currents source of spatial and temporal distortions in Bo. most frequently encountered in clinical DWI because of the high amplitude and long duration of diffusion- sensitizing gradients. When diffusion gradient applied, change in magnetic field creates electrical currents in neighboring conductive surfaces. Such currents create smaller magnetic fields (i.e. eddy currents) that modify Bo. modern gradient coils equipped with active shielding to avoid these effects of electrical conduction, eddy currents are not as obtrusive in routine clinical imaging as they were in the past. 4/23/2013 MRI artifacts-sudil 22

23. 4/23/2013 MRI artifacts-sudil 23 Remedy Pre-compensation- A “distorted” gradient waveform is used which corrects to normal with the eddy current effects. Shielded gradients – Active shielding coils between gradient coils and main gradients.

24. 2. Gradient field nonlinearity Occurs in all MR imaging systems and primarily related to gradient falloff due to the finite size of the gradient coils. Predictable. Easily corrected by system software , with corrections applied before the final images are constructed. Operator unaware of occurrence of mapping errors due to gradient field nonlinearity. Although post processing techniques can correct distortions resulting from gradient field nonlinearity, cannot compensate for losses in spatial resolution that are related to gradient field nonlinearity. 4/23/2013 MRI artifacts-sudil 24

25. 3. RF field inhomogeneities Do not cause geometric distortions but contribute to signal nonuniformity . May arise from problems in RF coil construction or standing wave (dielectric) effects. Because the Larmor frequency of protons increases with increasing field strength, a high-frequency pulse is needed to excite signal producing protons at MR imaging with high field strengths such as 3 T. When the RF wavelength is shorter than the dimensions of the anatomic structures examined at clinical MR imaging, standing waves may result. Leads to inhomogeneous fat suppression. 4/23/2013 MRI artifacts-sudil 25

26. 4/23/2013 MRI artifacts-sudil 26 Remedy Shimming- allows precise control of overall homogeneity of RF field. Use STIR for Fat sat than spectral tech. like CHESS. Dielectric – use phased array coils, software compensation

27. Aliasing artifacts Field of view: dimensions of the anatomic region to be included in imaging. mathematic product of the acquisition matrix and pixel dimensions. Chosen considering size of structure to be evaluated and trade-offs between SNR and spatial resolution. With a constant imaging matrix, a smaller FOV results in higher spatial resolution but lower SNR . Choosing an FOV that is smaller than the area imaged leads to wraparound or aliasing artifacts. 4/23/2013 MRI artifacts-sudil 27

28. Echoes are sampled along the FE direction at the sampling bandwidth rate , with higher rates resulting in a greater range of frequency sampling. Nyquist frequency - highest frequency that may be clearly sampled, with higher frequencies corresponding to tissues outside the specified FOV. High frequencies outside the FOV falsely detected as lower frequencies which leads to a wraparound artifact on the reconstructed images. 4/23/2013 MRI artifacts-sudil 28

29. 4/23/2013 MRI artifacts-sudil 29

30. 4/23/2013 MRI artifacts-sudil 30 Remedy Increase the FOV (decreases resolution). Oversampling the data in the frequency direction (standard) and increasing phase steps in the phase-encoded direction – phase compensation (time or SNR penalty). Swapping phase and frequency direction so phase is in the narrower direction. Use surface coil so no signal detected outside of FOV . Saturation pulses may also be applied to structures in the nonimaged portion of the FOV to reduce signal and, thus, signal overlap.

31. Magnetic susceptibility artifacts Inaccurate spatial encoding from susceptibility gradients within tissue leads to distortion of anatomic structures. Artifact resulting from the presence of metallic objects, not only distorts nearby structures but also may result in signal dropout, depending on the sequence used. The effects are field strength dependent, and the potential for metallic object–related artifacts is greater at 3 T than at lower magnetic field strengths. However, the increase in magnetic field strength from 1.5 to 3 T results in a significant improvement in SNR , allowing the use of a higher bandwidth sampling rate and parallel imaging to reduce susceptibility artifacts. Worst with long TE and gradient echo sequences. 4/23/2013 MRI artifacts-sudil 31

32. 4/23/2013 MRI artifacts-sudil 32

33. 4/23/2013 MRI artifacts-sudil 33 Remedy I maging at low magnetic field strength, using smaller voxels , decreasing echo time, and increasing receiver bandwidth. Gradient-echo and echo-planar sequences should be avoided, because they increase susceptibility artifacts. The use of spin-echo and particularly fast spin-echo sequences should be considered.

34. Chemical shift artifacts Protons in fat and water precess at different frequencies in an applied magnetic field. The separation between their resonance frequencies increases with increasing field strength. Eg . At 1.5 T , freqency diff. is 220 Hz, but at 1 T the diff. is 147 Hz and at lower field strengths (0.5 T or less ) usually insignificant. The chemical shift differences lead to spatial misregistration of the MR signal; i.e. differences in the Larmor frequency are mistaken for differences in spatial position along the frequency encoding axis. The resultant chemical shift artifacts on images manifest most prominently at fat-water interfaces. 4/23/2013 MRI artifacts-sudil 34

35. Amount of chemical shift is expressed in arbitrary units known as parts per million ( ppm ) of Bo. It’s value is always independent of Bo and equals 3.5 ppm . O ccurs in the frequency encoding direction only. 4/23/2013 MRI artifacts-sudil 35

36. Remedy Imaging at low magnetic field strength, by increasing receiver bandwidth, or by decreasing voxel size. T1 -weighted - The artifacts tend to be more prominent on T2-weighted than on T1-weighted images. Fat suppression methods often eliminate. 4/23/2013 36 MRI artifacts-sudil

37. Chemical misregistration artifact Also produced as a result of the precessional frequency diff. between fat and water. But this is caused because fat and water are in phase at certain times and out of phase at others, due to difference in their precessional frequency. When they are in phase their signals add constructively and when out of phase the signals cancel each other out. This cancellation effect is known as chemical misregistration artifact. 4/23/2013 MRI artifacts-sudil 37

38. Causes a ring of dark signal around certain organs where fat and water interfaces occur within the same voxel . Eg . Kidneys Mainly occurs in PE direction as it is produced due to phase difference between fat and water. Most degrading to the image in gradient echo pulse sequences where gradient reversal is very ineffective. 4/23/2013 MRI artifacts-sudil 38

39. Remedy Use SE sequence In GRE, select a TE that corresponds to the periodicity of fat and water ie . Select a TE that generates an echo when fat and water are in phase. 4/23/2013 MRI artifacts-sudil 39

40. Partial volume artifacts Partial volume occurs if slice thickness > thickness of tissue of interest Occurs when multiple tissue types are encompassed within a single voxel If small structure is entirely contained within the slice thickness along with other tissue of differing signal intensities, the resulting signal displayed on the image is a combination of these two intensities. This reduces contrast of the small structure. If the slice is the same thickness or thinner than the small structure, only that structures signal intensity is displayed on the image. Volume averaging is most likely to occur in the slice-selection direction of the image. 4/23/2013 MRI artifacts-sudil 40

41. 4/23/2013 MRI artifacts-sudil 41 Remedy Decreasing voxel size, particularly reducing section thickness. Three-dimensional Fourier transform imaging is particularly useful, because it provides thin sections with no intervening gaps and is conductive to reformatting in alternate imaging planes. Multiplanar imaging option helps to clarify.

42. Signal truncation artifacts Occur in regions of boundary between high and low signal intensity Caused by approximation errors in Fourier transform analysis. As the signal is sampled over a limited period of time, some data are necessarily omitted (truncated) in k-space, causing the signal intensity of a given pixel on the final image to vary from its ideal signal intensity. Commonly seen at the interface of the low-signal intensity spinal cord with high-signal-intensity CSF on T2WI of the spine, mimic spinal canal dilatation (ie. Hydromyelia,syrinx). Appears as a periodic “ringing” at high contrast interfaces . 4/23/2013 MRI artifacts-sudil 42

43. 4/23/2013 MRI artifacts-sudil 43 128x256 256x256 Remedy Use of higher resolution imaging matrix and filtration methods.(under sampling avoided) Gradient reorientation will displace the artifacts to another portion of the image.

44. Slice-overlap (cross-slice) artifacts Loss of signal seen in an image from a multi-angle, multi-slice acquisition. If the slices obtained at different disk spaces are not parallel, then the slices may overlap when two levels are done at the same time, e.g ., L4 -5 and L5-S1 . The level acquired second will include spins that have already been saturated . This causes a band of signal loss crossing horizontally in image, usually worst posteriorly . Therefore, overlap of sections within areas of diagnostic interest should be carefully avoided. 4/23/2013 MRI artifacts-sudil 44

45. 4/23/2013 MRI artifacts-sudil 45 Remedy Avoid steep change in angle between slice groups. Use separate acquisitions. Use small flip angle.

46. Cross-excitation artifacts The imperfect shape of RF slice profiles leads to the unintended excitation of adjacent tissue. This excitation results in the saturation of such tissue M anifest as decreased signal intensity and decreased contrast that can hinder lesion detection. 4/23/2013 46 MRI artifacts-sudil

47. Remedy Introduce an intersection gap that is 10% to 50% of the prescribed section thickness. Interleaved image acquisition, in which odd-numbered sections are initially acquired,followed by acquisition of even-numbered sections. optimized RF pulses that have a more rectangular slice profile can be implemented. 4/23/2013 MRI artifacts-sudil 47

48. Cross-talk Artifact Perfect RF pulse is a sinc function (FT = ‘top hat’) Real RF pulse is a truncated sinc (FT = ‘top hat with rounded edges’) Result of imperfect slice excitation of adjacent slices causing reduction in signal over entire image. 4/23/2013 MRI artifacts-sudil 48

49. 4/23/2013 MRI artifacts-sudil 49 Inter-slice cross talk could cause increased T1 weighting and reduced SNR . May be reduced by using gap, interleaving slices and optimized (but longer) RF pulses.

50. Magic Angle Effects Produced by the particular physical properties of fibrillary tissues and their interaction with the static magnetic field. Seen most frequently in tendons and ligaments that are oriented at a 55 o angle to the main magnetic field. Due to dipolar interactions that reduce their T2 relaxation time. Normal dipolar interactions between the H+’s in water molecule aligned in tendons shortens T2 , causing loss of signal. T2 relaxation time is lengthened and maximal when these fibrillary structures are at a 55° angle to B0 . Maximal for short TE. 4/23/2013 MRI artifacts-sudil 50

51. Remedy Lengthening TE T1 weighted imaging 4/23/2013 MRI artifacts-sudil 51

52. Zipper Artifacts Most are related to hardware or software problems May occur in either frequency or phase direction. Zipper artifacts from RF entering room during image acquisition are oriented perpendicular to the frequency direction and easily controlled. 4/23/2013 MRI artifacts-sudil 52

53. Spike artifact Caused by one ‘bad’ data point in k-space. Fig. shows one data point in k-space, which is out of the ordinary. The resulting image show diagonal lines throughout the image. Remedy - Repeat the scan. 4/23/2013 MRI artifacts-sudil 53

54. Zebra stripes Observed along the periphery of gradient-echo images (abrupt transition in magnetization at the air-tissue interface) Increased by aliasing that results from the use of a relatively small field of view. May also occur when pt. touches the coil or a result of phase wrap. Remedy expanding the FOV , using SE pulse sequences. using oversampling techniques to reduce aliasing. 4/23/2013 MRI artifacts-sudil 54

55. RF Overflow Artifacts (Clipping) Causes a nonuniform , washed-out appearance to an image. Occurs when the signal received from the amplifier exceeds the dynamic range the analog-to-digital converter causing clipping. Autoprescanning usually adjusts the receiver gain to prevent this from occurring. 4/23/2013 55 MRI artifacts-sudil

56. Moire Fringes An interference pattern most commonly seen when doing gradient echo images. One cause is aliasing of one side of the body to the other results in superimposition of signals of different phases that add and cancel. Can also be caused by receiver picking up a stimulated echo. Similar to the effect of looking though two window screens. 4/23/2013 56 MRI artifacts-sudil

57. Central Point Artifact A focal dot of increased or decreased signal in the center of an image. Caused by a constant offset of the DC voltage in the amplifiers . Remedy Requires recalibration by engineer Maintain a constant temperature in equipment room for amplifiers. 4/23/2013 57 MRI artifacts-sudil

58. Quadrature ghost artifact Another amplifier artifact caused by unbalanced gain in the two channels of a quadrature coil. Combining two signals of different intensity causes some frequencies to become less than zero causing 180 degree “ghost.” 4/23/2013 58 MRI artifacts-sudil

59. Entry slice (Inflow) phenomenon Unsaturated spins in blood or CSF entering the initial slices results in greater signal then reduces on subsequent slices . Characterized by bright signal in a blood vessel (artery or vein) at entry site. May be confused with thrombus . The use of gradient echo flow techniques can be used to differentiate entry slice artifacts from occlusions. Can cause spatial saturation to reduce. Mechanism for TOF angiography. 4/23/2013 MRI artifacts-sudil 59

60. Shading artifacts Produces a loss of signal intensity in one part of image. Main cause is uneven excitation of nuclei within the pt. due to RF pulses applied at flip angles other than 90* and 180* Also caused by abnormal loading on coil or by coupling of coil at one point. This may occur with large pt. who touches one side of the body coil and couples it at that point. Appear as foci of relatively reduced signal intensity involving a portion of the image. Abnormalities contained in the shaded portion of the MR image may be obscured. Also be caused by inhomogeneities in the main magnetic field that can be improved by shimming. 4/23/2013 MRI artifacts-sudil 60

61. Remedy Always ensure that coil is loaded correctly i.e correct size of coil for anatomy under examination, and pt. is not touching the coil at any point. Use of foam pads or water bags bet.n coil and patient Ensure that appropriate pre-scan parameters have been obtained before the scan, as these determine the correct excitation frequency and amplitude of applied RF pulses. 4/23/2013 MRI artifacts-sudil 61

62. Conclusion… Artifacts in MR images are an inevitable truth. MRI arifacts occur because one or more of the assumptions underlying the imaging principles have been violated. Some can be reduced while others can be totally eliminated. Artifact correction methods usually involve one or more of the following: Hardware calibration Scanning parameter optimization Special pulse sequence design Signal and image postprocessing By understanding the mechanism of their production and their effects on the final image, technologists should considerably try to minimize these artifacts with the use of reduction techniques. Ideally, we want all image artifacts to be below the level of user's perception. Artifact correction is an active area of research today, and will continue to be in the future as advances in MRI technology reveal new image information and new kinds of artifacts. 4/23/2013 MRI artifacts-sudil 62

63. Lastly… Observer artifact: Self explanatory Otherwise known as “Upside down Error” Apply for time off from duty. 4/23/2013 MRI artifacts-sudil 63

64. Find more at…. Morelli JN , Runge VM , Ai F, et.al. An Image-based Approach to Understanding the Physics of MR Artifacts. RadioGraphics 2011; 31:849–866 MRI in practice, 2 nd edn . By Catherine Westbrook and Carolyn Kaut MRI artifacts, PPT presentation by Ray Ballinger MRI physics course; Artifacts and suppression technique by Jerry Allisson www.mr-tip.com www.mritutor.org 4/23/2013 MRI artifacts-sudil 64

65. On examining a knee with prosthesis in situ, what artifact is expected? Difference between chemical shift and chemical misregistration Truncation artifact and reduction List different motion compensation options. Why is motion artifact seen only in PE direction? What are the sources of zipper artifact? Why does aliasing occur? Difference between cross talk and cross excitation. 4/23/2013 MRI artifacts-sudil 65

66. 4/23/2013 MRI artifacts-sudil 66 THANK YOU!!!