Mucosal_Drug_Delivery_with_Diagrams.pptx

A ppt on mucosal drug delivery system.

1. Mucosal Drug Delivery System With Flowcharts and Diagrams

2. Introduction • Mucosal drug delivery: through buccal, nasal, ocular, rectal, vaginal mucosa. • Provides systemic or local drug effects. • Highly vascularized mucosa → rapid absorption. • Avoids gastrointestinal degradation and first-pass metabolism.

3. Principles of Mucoadhesion • Bioadhesion: adherence to biological surface. • Mucoadhesion: adherence to mucosal surfaces. Stages: 1. Contact Stage 2. Consolidation Stage

4. Stages of Mucoadhesion (Flowchart)

5. Mechanisms of Mucoadhesion • Electronic theory – electrostatic forces. • Wetting theory – adhesive spreading. • Diffusion theory – interpenetration. • Adsorption theory – H-bonding, Van der Waals. • Fracture theory – separation strength.

6. Concepts • Polymers: Chitosan, Carbopol, HPMC, PVA, Sodium alginate, Polycarbophil. • Ideal polymers: - Non-toxic, biocompatible - Swellable, flexible - High molecular weight - Strong adhesion

7. Advantages vs Disadvantages

8. Transmucosal Permeability • Factors: - Drug lipophilicity, solubility, size. - Mucosal thickness, blood flow, enzymes. - Permeation enhancers: surfactants, bile salts. - Salivary pH and buffer capacity. • Pathways: - Transcellular (lipophilic drugs) - Paracellular (hydrophilic molecules)

9. Buccal Formulation Considerations