Nasopulmonery Drug delivery system & in NDDS

How to work drug delivery system in nasal..

1. NASOPULMONERY DRUG DELIVERY SYSTEMS SAGAR INSTITUTE OF TECHNOLOGY & MANAGEMENT DEPARTMENT OF PHARMACY BBK TOPIC PRESENTED TO - PRESENTED BY - Dr. Pooja Director of Sagar Institute of Technology & Management Department of Pharmacy , Barabanki Lavkush kumar B . Pharm 4 th Year

2. CONTENT Introduction Why we need NPDDs Advantages Disadvantages Mechanism of drug absorption Factor influencing nasal absorption Formulation

3. In ancient times the Indian Ayurvedic system of medicines used nasal route or administration of drug and the process is called as “ Nasya ”
Intranasal drug delivery is now recognized to be a useful and reliable alternative to oral and parenteral routes. Undoubtedly, the intranasal administration of medicines. For the symptomatic relief and prevention or treatment of topical nasal conditions has been widely used for a long period of time.
However, recently, the nasal mucosa has seriously emerged as a therapeutically viable route for the systemic drug delivery. INTRODUCTION

4. WHY WE NEED NASOPULMONARY DRUG DELIVERY SYSTEMS

5. Hepatic first pass metabolism avoided.
Rapid drug absorption and quick onset of action.
Bioavailability of larger drug molecules can be improved by means of absorption enhancer.
BA for smaller drug molecules is good. Convenient for long term therapy, compared to parenteral medication.
Drugs possessing poor stability G.I.T fluids given by nasal route.
Easy and convenient.
Easily administered to unconscious patients. ADVANTAGES

6. Pathologic conditions such as cold or allergies may alter significantly the nasal bioavailability.
The histological toxicity of absorption enhancers used in nasal drug delivery system is not yet clearly established.
Relatively inconvenient to patients when compared to oral delivery systems since there is a possibility of nasal irritation
Nasal cavity provides smaller absorption surface area when compared to GIT. DISADVANTAGES

7. MECHANISM OF DRUG ABSROPTION Drug are dissolved in two major pathways Transcellular (Passive Diffusion) – Transport of lipophilic drugs passive diffusion/ active diffusion Paracellular (Between cells) – For hydrophilic and small-molecular-weight drugs .

8. Mucoadhesive Carrier Hydration & swell of polymers Hydrophilic Macromolecules drug Internal Absorption Enzymatic Metabolism Cilliary Clearance Drug release Interaction with Mucus

9. FACTOR INFLUENCING NASAL ABSROPTION Biological factor Physiology factor Drug related factor Formulation related factor Mucociliary Clearance Nasal Secretion pH of nasal activity Dosage form Contact time &drug conc. Osmolarity Drug Disposition &Deposition Viscosity Molecular weight Particle size pKa & Partition coefficient Lipophilicity Biochemical Enzymatic inhibition Structural Features