New Strategies for evaluating Natural Products.pptx

New Strategies for evaluating Natural Products - Dr.M.Jothimuniyandi- Omics technologies-Bioinformatics and computational methods-Extraction and Isolation Techniques-Bioassay –Guided Fractionation-Network Pharmacology-Nanotechnology-Ethanopahrmacological Approaches-Chemical Synthesis and Semi Synthesis-Phytochemical Fingerprinting-Sustainable and ethical Sourcing Bioprospecting.

1. New Strategies for evaluating Natural Products Dr.M.Jothimuniyandi Assistant Professor

2. Introduction Evaluating natural products is a multifaceted endeavor that involves identifying and assessing the biological activities, chemical compositions and potential therapeutic uses of substance derived from natural sources. Here are some new and innovative strategies foe evaluating natural products.

3. Omics technologies It’s inherent complexity of biology, series of ‘ O mics ' technologies like  genomics (NGS, CRISPR-Cas-9), proteomics, metabolomics (MS, NMR), lipidomics  etc . An Omics technology offers a comprehensive view of the molecules that make up a cell, tissue or organism .

4. Bioinformatics and computational methods In this method, develops and applies computational methods to analyze large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology . Through this technique can predict biological activity and toxicity of natural products based on chemical structure and bioactivity data.

5. Extraction and Isolation Techniques Different extraction techniques such as  supercritical-fluid extraction, microwave-assisted extraction, ultrasound-assisted extraction, subcritical solvent extraction and solid-phase micro extraction   are efficient for isolating of bioactive compounds from complex mixtures.  

6. Bioassay –Guided Fractionation A technique for profiling and screening of plant extracts for bioactive compounds with potential sources of new bio-based drugs. It is  useful to find the actual active compound from an extract. The bioassay is acting as a very specific detector.

7. Network Pharmacology Network pharmacology integrates data from genomics, proteomics and metabolomics to understand the complex interactions between natural products and biological systems.

8. Nanotechnology Nanocarries: Nanocarries are defined as colloidal drug-delivery systems containing submicron sizes in the nanometer range. It Utilizing nanoparticles to deliver plant products can enhance their drug stability and solubility, drug bioactivity, and site-specific delivery of drugs as well as high surface area.

9. Ethanopahrmacological Approaches Ethanobotany: It is the study of interrelations between humans and plants . Documenting and scientifically validating the traditional uses of plants and other natural products by indigenous people can reveal new bioactive compounds.

10. Chemical Synthesis and Semi Synthesis Synthesizing natural products in the lab helps confirm their structure and provides materials for further study. Modifying natural products to improve their pharmacological properties or reduce toxicity.

11. Phytochemical Fingerprinting HPLC, HPTLC, LCMS and GCMS: An effective tool for linking the chemical constituent’s profile of the plant qualitative and quantitative estimation of chemical and bio-chemical markers. It has the potential to determine authenticity and reliability of chemical constituent of herbal drugs and formulations.

12. Sustainable and ethical Sourcing B ioprospecting These process of natural products ensures biodiversity conservation and fair sharing of benefits with home communities. By interacting these advanced strategies, researchers can more effectively evaluate the therapeutic potential of natural products, leading to the development of new drugs and treatments.

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