Nucleotide excision repair

Nucleotide excision repair

1. BY SHRUSHTI JOSHI 164551 NUCLEOTIDE EXCISION REPAIR

2. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). Discovered by Philip Courtland Hanawalt , in 1964 INTRODUCTION

3. NER can be divided into two subpathways : global genomic NER (GG-NER or GGR) Xeroderma pigmentosum (XP) transcription coupled NER (TC-NER or TCR) Cockayne syndrome (CS) TYPES

4. PROKARYOTIC NER

5. EUKARYOTIC NER

6. Xeroderma pigmentosum ( XP ) is a rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient. Those affected with XP are extremely sensitive to UV light produced by the sun and even with a short exposure to it causes dry, flaking skin and pigmented spots that can develop into skin cancer. XERODERMA PIGMENTOSUM

7. Cockayne syndrome ( CS ), also called Neill- Dingwall syndrome , is a rare and fatal autosomal recessive neurodegenerative disorder. In contrast to cells with normal repair capability, CSA and CSB deficient cells are unable to preferentially repair UV-induced cyclobutane pyrimidine dimers in the template strand of actively transcribed genes. It is named after English physician Edward Alfred Cockayne who first described it in 1936. COCKAYNE SYNDROME

8. RECENT RESEARCH

9. Dynamic maps of UV damage formation and repair for the human genome Jinchuan Hu , Ogun Adebali, Sheera Adar, and Aziz Sancar

10. . wikipedia.org /wiki/ Nucleotide_excision_repair ncbi.nlm.nih.gov nature.com Cold spring harbor laboratory press REFERENCENES

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