Nux Vomica

Uses, side effects

1. A Presentation On Nux Vomica Submitted To: Assistant Professor Pharmacy Discipline, Khulna University, Khulna. Submitted By: 151115 Year : 2 nd , Term: 1 st Pharmacy Discipline, Khulna University, Khulna. Date of Submission: 31 May, 2016

2. Nux vomica

3. Nux vomica is the homeopathic remedy that is created from the seeds of the strychnos nux vomica tree. This tree is an evergreen tree. Nux-vomica is from two Latin words meaning, “ a nut that causes vomiting”. Figure: Nux vomica tree with fruits Nux vomica

4. Biological source : Nux vomica is the ripe, dried seed of strychonos nux-vomica. Synonyms : Family : Loganiaceae Nux vomica seed Kuchla ( Hindi) Poison nut Vomit nut Bachelor’s buttons Dog buttons Quaker buttons Semen strychnos Figure: Nux vomica seeds

5. Kingdom Plantae – Plants Subkingdom Tracheobionta – Vascular plants Superdivision Spermatophyta – Seed plants Division Magnoliophyta – Flowering plants Class Magnoliopsida – Dicotyledons Subclass- Asteridae Order- Gentianales Family Loganiaceae – Logania family Genus Strychnos L. – strychnos P Species Strychnos nux-vomica L. Scientific classification

6. Geographical source : The plant is native to east indies and also found in the forests of Morphology: Sri Lanka Malabar coast Northern Australia and India

7. Branches are irregular and covered with a smooth ash-colored bark. Flowers are small , greeny-white, funnel shape, in small terminal cymes and have a disagreeable smell. It blooms in the cold season. Fruit size is large with a smooth hard rind or shell. When the fruit is ripen, it gets a lovely orange color , filled with a soft white jelly-like pulp containing five seeds covered with a soft woolly-like substance, white and horny internally. The seeds are removed when the fruits are riped, cleansed, dried and sorted. Seed is disc shaped, 10-30mm in diameter, 4-6mm thick.

8. Cultivation and Collection : It grows well in tropical and sub tropical climate. It is propagated by seeds. Seeds are sown in polythene bags during May – June. Before sowing the seeds, it is soaked in water so that there sill be better germination . The seeds will germinate within 20 - 25 days . The seedling are planted at a distance of 6 x 6 m distance during July . The tree comes to flower after about three years of planting. Flowering starts in the month of August and fruits ripen during October.

9. Chemical Constituents : Alkaloids :1.8-5.3% Loganine : As glycoside Fixed oil: 3% Caffeotannic acid Proteins Chlorgenic acid Strychnine Brucine α -Colubrine β -Colubrine 3-methoxyicajine Vomicine Novacine Protostrychnine N-oxystrychnine Isostrychnine

10. Loganine Vomicine

11. Strychnine

12. Strychnine

13. Strychnine

14. Strychnine

15. Strychnine

16. Strychnine

17. Strychnine

18. Strychnine

19. Chemical Tests : Strychnine Test : A mixture of ammonium vandate and sulphuric acid on addition to strychnine or a thick section of endosperm gives purple color. Potassium Dichromate Test : Addition of potassium dichromate and conc. H 2 SO 4 with strychnine forms violet color. Brucine Test : Addition of conc. HNO 3 to brucine or thick section of endosperm produces yellow to orange color.

20. How Does it work? Nux vomica contains strychnine and other chemicals that affect the brain and cause muscle contractions. This can lead to convulsions and death. Strychnine in amounts that are too small to produce symptoms can still be a serious problem. Small amounts of strychnine build up in the body with continued use, especially in people with liver disease. This can cause death in a period of weeks. Strychnine poisoning can be detected with laboratory tests.

21. Mental: Does not want to be touched, Sedentary life style, Impatient. Coughs: Dry and tickling cough, Feeling that coughs tears something loose in chest. Influenza: Nausea, Cannot get warm, Shivering-especially after drinking. Head: Over sensitiveness, Congestive headache, related with hemorrhoids. Eyes: Photophobia Optic neuritis. Female: Menses too early lasts too long ,Dysmenorrhœa & Inefficient labor-pain, Metrorrhagia. Male: Weakness and irritability, Spermatorrhœa, with dreams; Pain in testicles, Orchitis . Symptoms:

22. In atonic dyspepsia as circulatory stimulant as nervine as sex tonic as stimulant for GIT improve digestion increases blood presure in over sensitivity & irritability as anti-tumor as nervous system stimulant as pain reliever in relieve paralysis Medicinal Uses :

23. Traditional Uses: Nux - vomica is a common homeopathic medicine prescribed for digestive problem, sensitivity to cold, Irritability, Mental strain from over working, Self indulgence, Ineffectual urge to vomit. Impatience.

24. Most accidental poisoning is by breathing in the powder or by absorption through the skin.

25. Taking nux vomica for more than a week, or in high amounts of 30 mg or more, can cause several problems. Like restlessness anxiety, dizziness , neck and back stiffness, spasms of jaw and neck muscles, convulsions, seizures, breathing problems, liver failure, and death . Taking nux vomica can harm both mother and child during pregnancy. The strychnine in nux vomica can cause liver damage or make liver disease worse.

26. Manufacturing

27. Market Preparations

28. Thank you