OECD_Guidelines for Experimental pharmacology

Notes

1. OECD Guidelines for Laboratory Animals A Study on Ethical and Scientific Standards

2. Introduction The Organisation for Economic Co-operation and Development (OECD) provides internationally accepted guidelines for laboratory animal studies. These guidelines focus on toxicological and pharmacological testing, ensuring ethical and scientific integrity in research.

3. Good Laboratory Practices (GLP) - Standardized procedures and proper documentation must be followed. - Ensures reliability, reproducibility, and ethical treatment of laboratory animals. - Data integrity and scientific reproducibility must be ensured.

4. Maintenance of Laboratory Animals - Proper environmental conditions must be maintained. - Housing should be species-specific with adequate space and bedding. - Temperature (22-24°C), humidity (50-70%), and lighting conditions should be regulated. - Health monitoring programs should be implemented.

5. Conduct of Experiments - Acute and chronic toxicity testing should follow ethical guidelines. - Reproductive and developmental toxicity assessments must be conducted. - Carcinogenicity and safety studies should be performed under controlled conditions. - The 3Rs principle (Replacement, Reduction, Refinement) should be implemented to minimize animal use.

6. Conclusion The OECD guidelines ensure ethical, humane, and standardized research practices globally. By following these regulations, scientific research maintains credibility while minimizing harm to laboratory animals.