Oestrogen

Biosynthesis & Chemical structure of Oestrogen

1. Chemical nature & Biosynthesis of Oestrogen S.Kaayathri Devi 19PO03 I M.Sc., Biotechology

2. Oestrogen -Introduction

3. In 1929, Adolf Butenandt and Edward Adelbert Doisy isolated and purified estrone, the first estrogen   to be discovered . Basically, there are 3 estrogens : estrone(E1), estradiol(E2) & estriol(E3). Estrogens , in females, are   produced primarily by the ovaries, and during pregnancy by the placenta. Follicle-stimulating hormone (FSH) stimulates the ovarian production  of  estrogens  by the granulosa cells of the ovarian follicles and corpus luteum of ovaries. It is a Steroid hormone.

4. Biosynthesis of Oestrogen

5. Biosynthesis of Estrogen

6. Functions of Oestrogen

7. Physiological functions Growth, development and maintenance of female reproductive system. Maintenence of menstrual cycle. Development of female secondary sexual characteristics.

8. Biochemical functions Lipogenic effect : Increases lipogenesis in adipose tissues.Women have relatively more fat than men(<5%). Hypocholestrolemic effect: Lowers plasma total cholesterol. LDL fraction of lipoproteins is decreased while HDL is incresed. Lower incidence of atherosclerosis & coronary heart diseases in women in reproductive age.

9. Anabolic effect : Promotes transcription & translation.Elevates protein synthesis in liver.E.g : transferrin & ceruloplasmin. Effect on bone growth : Promotes calcification & bone growth. Decalcification of bones in post menopausal women – due to lack of estrogen. Effect on transhydrogenase: Transhydrogenase – enzyme activated by estrogen. NAD+ NADH. NADH formed can be oxidized.

10. After menopause,transhydrogenase activity – lowered – due to the lack of estrogens. NADH – diverted to lipogenesis – obesity.