ORamaVR at Open Coffee Athens CI

A presentation by George Papagiannakis

1. Transform virtual training, reform real medicine “ learn, relearn, unlearn ”

2. The problem we are addressing 150-year old Surgical Training Model Master: Educates while working Apprentice: Builds career & learns while operating Estimated Costs: $48,000 per apprentice per year in OR time alone ) OR Time getting more restricted resulting in more surgical errors Limited Surgical Simulation Robotic simulators: expensive, anchored, not for open surgery (Estimated costs: $ 150,000 per robotic simulator) Medical Errors dramatic increase Third highest cause of death in the U.S. (10 percent of all U.S. deaths are now due to medical errors)

3. Our Medical VR ed -tech solution * AAHKS-FARE 2018 Award to NYU & ORamaVR The ground-breaking RCT Clinical Trial verified a, b, c above for the first time since the 2002 Yale study Reduces surgical errors (6x) through VR psychomotor training and accelerates learning Reduces training costs via skill transfer from VR to the Operating Room (reduces 29% OR time) Democratizes and scales up training with mass-produced VR h/w and rapid prototyping VR s/w The most advanced virtual reality (VR) software simulation-based learning platform

4. Encapsulated in our ovidVR Platform SDK , for any gamified, psychomotor VR training currently focusing on ortho-surgery operations: * * * Our deep, award winning* proprietary technology: MAGES M A G E S ulti -player, shared virtual collaborative operating room nalytics engine with cloud-based assessment amified rapid prototyping based on Geometric Algebra ducational Curriculum enhancing knowledge and skills emantic representation and rapid prototyping patterns

5. Academic, Vocational Ed / Training Corporate TAM: $ 432B Smart Education & Learning *1 “The simulation-based learning segment is anticipated to exhibit the highest CAGR owing to the fact that this mode enables corporates and educational institutions to create a realistic experience in a controlled environment. It also enables professionals and learners to practice, navigate, explore, and obtain more information through a virtual medium before they start working on real-life tasks.” SAM: $6.4B *2 Medical / Surgical Education SOM: $1.06B *1 https://www.grandviewresearch.com/press-release/global-smart-education-learning-market *2 proprietary market survey commissioned by ORamaVR to Borgstrom & Cumby Consulting , for the US and global market Currently 6 direct competitors Assume 16.6% of SAM TAM SOM SAM 80+ > 10 companies courses/ yr $30k-120k / course Our Market $2.5B / 8,400 Med-device Companies $3.9B / 600 Surgical Residency centers Smart Education & Learning Educational Technology Experiential learning, simulation-based learning

6. Over 60 event demonstrations Over 10 long-term installations University of Southern California , Keck Medical School, Prof. Dorr, Los Angeles, USA, 2017 Foundation for Research and Technology – Hellas, Heraklion, Greece, 2018 NYU Medical School , Prof. Macauley, New York, USA, 2018 University of Sydney, Prof. Jinman Kim, Sydney, Australia, 2018 University of Athens , Prof. Petrakis, Athens, Greece, 2018 Univesity of Geneva , Prof. Nadia Magnenat-Thalmann , 2018 Intel Executive Briefing Center , Santa Clara, California, USA, March 2018 Oculus (Facebook) , Menlo Park, CA, March 2018 HTC/ Vive , San Franscisco, CA, July 2018 Google , Mountain-View, July 2018 CES 2019, Las Vegas, January 2019 VR@Healthcare , Zurich, November 2018 ACM SIGGRAPH Asia , Tokyo, December 2018 AAOS , San Diego, February 2017 - EFFORT 2017 , Vienna, May 2017 6 Paying customers Our global engagement

7. Our Team 20+ years in Medicine, Orthopaedics Surgery , European Hip Society Secretary General, Founder ICAROS Ltd Prof. Eleftherios Tsiridis , MD, PhD Chief Medical Officer / VP Sales/ Co-founder 15+ years in Computer Science, VR/AR , Graphics , innovation, industry, Academia, Education Assoc. Prof. George Papagiannakis CEO / CTO / Co-founder 20+ years in business development , ex-General Manager Microsoft and Intel Chris Tsangos Board Member Stelios Georgiou Core VR Engine & mechanics BSc, MSc University of Crete, Computer Science Department Mike Kentros VR content developer BSc, MSc University of Crete, Computer Science Department Stratos Geronikolakis VR standalone & backend developer BSc, MSc University of Crete, Computer Science Department Steve Kateros , Lead Developer – VR UX & Level Design BSc, MSc University of Crete, Computer Science Department Paul Zikas Character gamification & rapid prototyping BSc, MSc University of Crete, Computer Science Department Nikos Lydatakis Lead Developer – Platform Architecture & SDK BSc, MSc University of Crete, Computer Science Department 20+ years in Computer vision, Robotics and Innovation, Academia Prof. Panos Trahanias Co-founder

8. Our B2C2B freemium Business model Freemium surgeons, physicians, health practitioners $ Medical Schools $$ Medical Device companies Current Products Description ORama -TKA Total Knee Arthroplasty, v2.4.14 Q3 2018 ORama -THA Total Hip Arthroplasty (cemented-uncemented), v2.4.14 Q3 2018 ORama -CO-OP Multi-Surgeon VR OR add-on, v2.4 Q3 2018 ovidVR Platform SDK VR software development kit for any VR educational process involving dexterous use of hands, v2.4 Q3 2018 ORama -Suturing Basic Surgical Skills, v1.0, 2018 ORama -Dental Basic Implant placement, v1.0, 2018 ORama -Abdominal In Production, Bowel anastomosis ORama-Trauma1 In Production, Endotracheal intubation ORama-Trauma2 In Production, Trauma Patient Transport B2C2B freemium Monetization Strategy: ORama Portal: http:// elearn.oramavr.com Sponsorships and advertising Registration and monthly license Accreditation fees Medical schools (Universities and hospitals) Monthly license fee per user Customization cost per medical module Medical device companies (implants/robotic surgery) Monthly license/customization cost GTM collaboration, mass-licensing agreements

9. http:// www.oramavr.com http:// elearn.oramavr.com 5205 Prospect Rd #135-340 San Jose, California CA 95129, USA Science and Technology Park of Crete 100 N. Plastira str. GR 70013 Heraklion, Crete, Greece Email :  [email protected] g [email protected] Thank you for your attention!!!