Ovarian tumor MBBS pathology lecture.pdf

Ovarian tumor

1. Ovarian Tumor

5. Serous Cystadenoma
Definition
Benign partially or completely cystic lesion measuring > 1 cm in size and
composed of cells resembling fallopian tube epithelium or cuboidal non
ciliated epithelium resembling ovarian surface epithelium.

6. Fig: Serous Cystadenoma

7. Fig: Serous Cystadenoma

11. Microscopic Description
➢Uniloculated to multilocular cysts lined by a single
layer of tall columnar ciliated cells resembling normal
tubal epithelium or cuboidal non ciliated epithelium
resembling ovarian surface epithelium
➢Stroma contains spindle fibroblasts.

12. Mucinous Cystadenoma
Definition
Benign mucinous neoplasm composed of cysts and
glands lined by mucinous epithelium lacking
architectural complexity or cytologic atypia.

13. Gross Description
➢Smooth or bosselated surface
➢Cystadenoma:
❑Uni or multilocular cyst with variably sized smooth
walled locules.
❑ Filled with dense, viscous, sticky, gelatinous material
❑ No solid areas or papillary excrescences
❑ Mean size 10 cm, rarely > 30 cm

14. Fig: Serous cystadenoma

15. Fig Serous cystadenoma

16. Fig MCA

17. Fig MCA

18. Microscopic Description
➢Uni or multilocular cystic neoplasm composed of multiple
cysts and glands lined by a single layer of bland mucinous
epithelium.

19. ➢Simple nonstratified mucinous epithelium – columnar, cuboidal to flat
nonciliated cells with Variable amounts of mucinous cytoplasm.

➢ Small basally located nuclei lacking cytological atypia
➢ > 80% are intestinal type containing goblet cells.
➢ Usually no epithelial stratification or tufting.
➢ Absent or minimal mitotic activity and apoptotic bodies.

20. Teratoma
➢Benign tumor of the ovary composed of mature
tissue representing at least 2 embryonic layers
(ectoderm, mesoderm or endoderm).

21. Teratoma contd..
➢Most common ovarian tumor (20% of all ovarian tumors,
95% of all ovarian germ cell tumors) occurring in
reproductive age.
➢10% bilateral

24. Microscopic Description
•Mixture of mature, benign tissues
–Ectodermal (most common): squamous epithelium,
sebaceous glands, hair follicles, brain tissue.
–Mesoderm (second most common): bone, cartilage,
smooth muscle, fibroadipose tissue.
–Endodermal: intestinal or respiratory epithelium, thyroid,
salivary gland.

28. Dysgerminoma
•Malignant primitive germ cell tumor with no
specific type of differentiation.

29. ➢Most common malignant ovarian germ cell tumor;
female counterpart to testicular seminoma.
➢Most common in children and young women.
➢Excellent prognosis with chemotherapy.

32. Microscopic Description
➢Histomorphology identical to that of testicular
seminoma.
➢ Nests of large, uniform polygonal cells with clear or
eosinophilic cytoplasm and distinct cell membranes.
➢May also show sheets, cords, macro nodules,
insular growth, microcysts, tubules,
pseudoglandular spaces or trabeculae.