OXYGEN CASCADE, HYPOXIA AND ODC copy.ppt

About oxygen cascade

1. OXYGEN CASCADE, HYPOXIA AND ODC - DR. SRAVANI -MODERATOR DR P RAJESHWAR SIR

2. INTRODUCTION Oxygen is vital for life sustaining aerobic respiration, which basically occurs in cellular mitochondria Normal oxygen content in mitochondria is 10mmhg. At a point below 1-2 mmhg, ( pasteur point) anerobic respiration sets in.

3. OXYGEN CASCADE O2 at air ( sea level) is 160 mmhg At mitochondria is 10 mmhg The o2 transport down this gradient in oxygen cascade

4. STEPS UPTAKE BY LUNGS TRANSPORT IN BLOOD GLOBAL DELIVERY TO TISSUES REGIONAL DISTRIBUTION OF O2 DELIVERY DIFFUSION FROM CAPILLARY TO CELL CELLULAR UTILIZATION OF O2

5. PULMONARY VENTILATION

6. RESPIRATORY MEMBRANE

7. In Combined (97%) form 1 gm Hb carries 1.31 ml of o2 Dissolved form(2-3%), obeys henrys law, 100ml plasma carries 0.3ml of o2 When FiO2 increased to 100% small amount of o2 dissolves in plasma at a rate of 0.3 ml/100 ml plasma But theres no significant increase in amount of o2 carried by hemoglobin as its already 95% saturated with oxygen

8. TYPES OF HYPOXIA

9. Oxygen flux The amount of oxygen which leaves left ventricle per minute. DO2 DO2= O2 Bound to Hb+ dissolved O2