OBJECTIVES
Describe when oxygen (O2) therapy is needed.
Assess the need for O2 therapy.
Describe what precautions and complications are associated with O2
therapy.
Select an O2 delivery system appropriate for the respiratory care plan.
Describe how to administer O2 to adults, children, and infants.
Describe how to identify and correct malfunctions of O2 delivery
systems.
Assess and monitor a patient’s response to O2 therapy.
Describe how and when to modify or recommend modification of O2
therapy.
Describe how to implement protocol-based O2 therapy.
Identify the indications, complications, and hazards of hyperbaric O2
therapy.
GOAL OF OXYGEN THERAPY
The overall goal of O2 therapy is to maintain
adequate tissue oxygenation, while minimizing
cardiopulmonary work.
Clinical objectives for O2 therapy are the following:
Correct documented or suspected acute hypoxemia
Decrease symptoms associated with chronic
hypoxemia
Decrease the workload hypoxemia imposes on the
cardiopulmonary system
PaO
2 at or below 60 mm Hg
Saturation O
2
< 90% resting
A drop in PO
2 10 mm Hg or 5% in O
2 sat.
during sleep
Symptoms or signs of heart failure (cor
pulmonale), pulmonary hypertension,
erythrocytosis, “P” pulmonale on EKG
O
2 THERAPY : INDICATIONS
Barometric Pressure
•High altitude
PIO
2
PAO
2
Inc O
2
Consumption
•Convulsions
•Thyrotoxicosis
•Shivering
•pyrexia
(7 % /
o
C)
Alveolar Ventilation
decreased
•Resp. depression
•Resp. muscle
paresis
•Dec resp. effort
(trauma)
•Airway obstruction
FiO2
•Low FiO2 during
anaesthesia
•Rebreathing
Low VA/Q
•
Abn. Pulmonary
shunt
•Pneumonia
•Lobar atelectasis
•ARDS
Normal Anat. shunt
• Abn.extra Pulm.
Shunt
•Cong. heart disease
•Right to left shunts
PaO
2
Cell
PO
2
Low Hb
concentration
•Anaemia
•CO poisoning
Low Perfusion
•local - PVD,
thrombosis
•gen – shock,Hypovol,
card. Failure
cardiac arrest
HYPOXIA
PaO2 AS AN INDICATOR FOR
OXYGEN THERAPY
PaO2
80 – 100 mm Hg : Normal
60 – 80 mm Hg : cold, clammy
extremities
< 60 mm Hg : cyanosis
< 40 mm Hg : mental deficiency
memory loss
< 30 mm Hg : bradycardia
cardiac arrest
PaO2 < 60 mm Hg IS A STRONG INDICATOR
FOR OXYGEN THERAPY
CLINICAL ASSESSMENT OF
HYPOXIA
MILD TO MODERATE SEVERE
CNS : restlessness somnolence, confusion
disorientation impaired judgement
lassitude loss of coordination
headache obtunded mental status
Cardiac : tachycardia bradycardia,
arrhythmia
mild hypertension hypotension
peripheral vasoconst.
Respiratory: dyspnea increasing dyspnoea,
tachypnea tachypnoea, possible
shallow & bradypnoea
laboured breathing
Skin : paleness, cold, clammy cyanosis
CLASSIFICATION
LOW FLOW SYSTEM
The gas flow is insufficient to meet patient’s peak
inspiratory and minute ventilatory requirement
O
2 provided is always diluted with air
FiO
2 varies with the patient’s ventilatory pattern
Deliver low and variable FiO
2
→
Variable
performance device
NASAL CANNULA
A plastic disposable
device consisting of two
tips or prongs 1 cm long,
connected to oxygen
tubing
Inserted into the
vestibule of the nose
FiO
2 – 24-40%
Flow – ¼ - 8L/min (adult)
< 2 L/min(child)
ESTIMATION OF FiO2
O
2
Flowrat
e
(L/min)
Fi O
2
1 0.21 - 0.24
2 0.24 – 0.28
3 0.28 – 0.34
4 0.34 – 0.38
5 0.38 – 0.42
6 0.42 – 0.46
Patient of normal
ventilatory pattern -
each litre/min of
nasal O
2 increases the
FiO
2 approximately
4%.
E.g. A patient using
nasal cannula at 4
L/min, has an
estimated FiO2 of 37%
(21 + 16)
NASAL CATHETER
•A soft plastic tube
with several small
holes at the tip
•Inserted along the
floor of either nasal
passage under
visualization till the
tip is just above and
behind the uvula
•Blindly inserted to a depth equal to the
distance from nose to tragus
•Should be replaced every 8 hrs
•Avoided in patients with maxillofacial
trauma, basal skull #, nasal obstruction and
coagulation abnormalities
TRANSTRACHEAL CATHETER
A thin Teflon catheter
Inserted surgically with
a guidewire between 2
nd
and 3
rd
tracheal rings
FiO
2
– 22-35%
Flow – ¼ - 4L/min
Increased anatomic
reservoir
Replace every 90 days
Estimation of Fio
2
from a low-flow system for patient
with normal ventilatory pattern
Cannula 6 L/min VT, 500 mL
Mechanical reservoir None Rate, 20 breaths per min
Anatomic reservoir 50 mL I/E ratio, 1:2
100% O
2
provided/sec100 mL Inspiratory time, 1 sec
Volume inspired O
2
expiratory time, 2 sec
Anatomic reservoir 50 mL
Flow/sec 100 mL
Inspired room air 0.2 × 350 mL = 70 mL
O
2
inspired 220 mL
FiO
2
220 O
2
= 0.44
500 TV
A patient with ideal ventilatory pattern who receives 6L/min O2 by
nasal cannula is receiving FiO
2
of 0.44.
If V
T is decreased to 250 mL:
Volume inspired O
2
Anatomic reservoir 50 mL
Flow/sec 100 mL
Inspired room air (0.20 × 100 cm
3
) 0.2 × 100 mL = 20 mL
O
2
inspired 170 mL
FiO
2
170 = 0.68
250
The larger the Vt or faster the respiratory rate, the lower the Fio
2
.
The smaller the Vt or lower the respiratory rate, the higher the Fio
2
.
↑minute ventilation → ↓ Fio
2
↓minute ventilation Fio
→↑
2
RESERVOIR SYSTEM
Reservoir system stores a reserve volume of O
2,
that equals or exceeds the patient’s tidal volume
Delivers moderate - high FiO
2
Variable performance device
To provide a fixed FiO
2, the reservoir volume must
exceed the patient’s tidal volume
RESERVOIR CANNULA
NASAL RESERVOIR PENDANT RESERVOIR
RESERVOIR MASKS
Commonly used reservoir system
Simple face mask
Partial rebreathing masks
Non rebreathing masks
SIMPLE FACE MASK
Reservoir - 100-200 ml
Variable performance device
FiO
2 varies with
O
2 input flow
mask volume
extent of air leakage
patient’s breathing pattern
FiO
2: 40 – 60%
Input flow range is 5-10 L/min
Minimum flow – 5L/min to
prevent CO
2
rebreathing
MERITS
Moderate but variable FiO2.
Good for patients with blocked
nasal passages and mouth
breathers
Easy to apply
DEMERITS
Uncomfortable
Interfere with further airway
care
Proper fitting is required
Risk of aspiration in
unconscious patient
Rebreathing (if input flow is
less than 5 L/min)
O
2
PARTIAL REBREATHING MASK
No valves
FiO2 - 60-80%
FGF > 8L/min
The bag should
remain inflated to
ensure the highest
FiO2 and to prevent
CO2 rebreathing
Reservoir capacity :
600 – 1000 ml
During expiration
O2 + first 1/3 of exhaled gas (anatomic dead
space) enters the bag and last 2/3 of
exhalation escapes out through ports
During inspiration
The first exhaled gas and O2 are inhaled
NON REBREATHING MASK
Has 3 unidirectional
valves
FiO
2 - 0.80 – 0.90
FGF – 10 – 15L/min
To deliver ~100% O
2,
bag should remain
inflated
Factors affecting FiO
2
air leakage
patient’s breathing
pattern
Expiratory valves allow the exhaled
gases to escape but prevent inhalation
of room air gases
Inspiratory valve prevents exhaled gas
flow into reservoir bag
HIGH FLOW SYSTEM
•The gas flow is sufficient to meet patient’s
peak inspiratory and minute ventilatory
requirement
•FiO
2
is independent of the the patient’s
ventilatory pattern
•Deliver low- moderate and fixed FiO
2
→
Fixed performance device
High-Flow Devices
To qualify as a high-flow device, a system should
provide at least 60 L/min total flow. This flow criterion
is based on the fact that the average adult peak
inspiratory flow during tidal ventilation is
approximately three times the minute volume.
Because 20 L/min is close to the upper limit of
sustainable minute volume for an ill person, a flow of 3
× 20, or 60 L/min, should suffice in most situations.
Usually flows are kept at >3 times
patient’s MV)
Includes
Ventimask (HAFOE)
Aerosol mask and T-piece with
nebulizers
AIR ENTRAINMENT DEVICES
Based on Bernoulli principle –
For an inviscid flow of a nonconducting
fluid, an increase in the speed of the
fluid occurs simultaneously with a
decrease in pressure or a decrease in
the fluid's potential energy.
VENTURI PRINCIPLE
A rapid velocity of gas exiting from a restricted
orifice will create subatmospheric lateral
pressures, resulting in atmospheric air being
entrained into the mainstream.
CHARACHTERISITICS OF AIR
ENTRAINMENT DEVICES
Amount of air entrained varies directly with
Size of the port
Velocity of O2 at jet
They dilute O
2 source with air - FiO
2 < 100%
The more air they entrain, the higher is the
total output flow but the lower is the
delivered FiO
2
STEP 2: ADD THE AIR-TO-OXYGEN RATIO
PARTS
1.7 + 1 = 2.7
STEP 3: MULTIPLY THE SUM OF THE RATIO
PARTS BY THE OXYGEN INPUT FLOW
2.7 X 15L/min = 41L/min
Calculation of Air to O
2
Entrainment Ratio using a magic
box
20
100
60
20
40 60 = 3 : 1
20
Approximate Air Entrainment Ratio and Gas
Flows for different Fio
2
Fio 2 (%) Ratio
Recommended
O
2 Flow (L/min)
Total Gas Flow
(to Port)
(L/min)
24 25.3:1 3 79
26 14.8:1 3 47
28 10.3:1 6 68
30 7.8:1 6 53
35 4.6:1 9 50
40 3.2:1 12 50
50 1.7:1 15 41
VENTURI / VENTI / HAFOE MASK
Mask consists of a jet orifice around which is
an air entrainment port
FiO
2 regulated by size of jet orifice and air
entrainment port
FiO2 – Low to moderate (0.24 – 0.60)
HIGH FLOW FIXED PERFORMANCE DEVICE
Varieties of Venti Masks
A fixed Fio
2 model A variable Fio
2
model
AIR ENTRAINMENT NEBULIZERS
Have a fixed orifice, thus, air-to-O2 ratio can be
altered by varying entrainment port size.
Fixed performance device
FiO2 - 28-100%
Max. gas flows – 14-16L/min
Device of choice for delivering O2 to patients
with artificial tracheal airways.
Provides humidity and temperature control
Aerosol mask Face tent Tracheostomy
collar
T tube
How to increase the FiO
2 capabilities of
air-entrainment nebulizers?
Adding open reservoir (50-150ml aerosol
tube)
Provide inspiratory reservoir (a 3-5 L
anaesthesia bag) with a one way expiratory
valve
Connect two or more nebulizers in parallel
Set nebulizer to low conc (to generate high
flow) and providing supplemental O2 into
delivery tube
BLENDING SYSTEMS
With a blending system,
separate pressurized air
and oxygen sources are
input.
The gases are mixed
either manually or with a
blender
FiO
2
– 24 – 100%
Provide flow > 60L/min
Allows precise control
over both FiO
2 and total
flow output - True fixed
performance devices
OXYGEN TENT
Consists of a canopy
placed over the head and
shoulders or over the
entire body of a patient
FiO
2 – 40-50%
Flow rates - 12-15L/minO
2
Variable performance
device
Provides concurrent
aerosol therapy
OXYGEN HOOD
An oxygen hood covers only
the head of the infant
O2 is delivered to hood
through either a heated
entrainment nebulizer or a
blending system
Fixed performance device
Fio2 – 21-100%
Minimum Flow > 7/min to
prevent CO2 accumulation
INCUBATOR
Incubators are polymethyl
methacrylate enclosures that
combine servo-controlled
convection heating with
supplemental O2
Provides temperature control
FiO2 – 40-50%
Flow 8-15 L/min
Variable performance
device
Hyperbaric oxygen therapy
Hyperbaric oxygen (HBO) therapy is the
therapeutic use of O2 at pressures greater than 1
atm
Most HBO therapy is conducted at pressures
between 2 ATA and 3 ATA
Methods of Administration
Multiplace chamber
capable of holding a
dozen or more people
air locks that allow
entry and exit without
altering the pressure
can achieve pressures
of 6 ATA or more
multiplace chambers
are ideal for the
management of
decompression sickness
and air embolism
Monoplace chamber
Transparent Plexiglas
cylinder large enough
only for a single
patient
Complications of Oxygen therapy
1. Oxygen toxicity
2. Depression of ventilation
3. Retinopathy of Prematurity
4. Absorption atelectasis
5. Fire hazard
1.O
2 Toxicity
Primarily affects lung and CNS
2 factors
PaO
2
Exposure time
CNS O
2 toxicity (Paul Bert effect)
occurs on breathing O
2
at pressure > 1 atm
tremors, twitching, convulsions
Pulmonary Oxygen toxicity
C/F
Acute tracheobronchitis
Cough and substernal pain
ARDS like state
Pulmonary O
2
Toxicity (Lorrain-
Smith effect)
High pO2 for a prolonged period of time
Intracellular generation of free radicals e.g.:
superoxide,H2O2 , singlet oxygen
React with cellular DNA, sulphydryl proteins &lipids
Limit patient exposure to 100% O2 to less than 24 hours whenever
possible. High FiO2 is acceptable if the concentration can be decreased
to 70% within 2 days and 50% or less in 5 days.
Goal should be to use lowest possible FiO2
compatible with adequate tissue oxygenation
Indications for 70% - 100%
oxygen therapy
Resuscitation
Periods of acute cardiopulmonary instability
Patient transport
Seen in COPD patients with chronic hypercapnia
2. Depression of Ventilation
3. Retinopathy of prematurity
(ROP)
Premature or low-birth-weight infants who receive
supplemental O
2
Mechanism
Increased PaO
2
Retinal vasoconstriction
Necrosis of blood vessels
New vessels formation
Hemorrhage retinal detachment and blindness
→
To minimize the risk of ROP - PaO
2
below 80 mmHg
100% O
2
oxygen
nitrogen
PO
2
=673
PCO
2 = 40
PH
2
O = 47
A
B
A – UNDERVENTILATED
B – NORMAL VENTILATED
5. Fire hazard
High FiO
2 increases the risk of fire
Preventive measures
Lowest effective FiO
2 should be used
Use of scavenging systems
Avoid use of outdated equipment such as
aluminium gas regulators
Fire prevention protocols should be followed for
hyperbaric O
2 therapy
PaO
2
< 10 mmHg in response to an oxygen
challenge of 0.2 – refractory hypoxemia
Implications of Oxygen challenge
concept
To identify refractory hypoxemia (as it does not
respond to increased FiO2)
Refractory hypoxemia depends on increased
cardiac output to maintain acceptable PaO2
Potentially deleterious effect of increased FiO2
can be avoided
SUMMARY
Therapeutic effectiveness of oxygen therapy is
limited to 25% - 50%
•Low V/Q hypoxemia is reversed with less than 50%
•DAA occurs with FiO2 more than 50%
•Pulmonary oxygen toxicity is a potential risk factor
with FiO2 more than 50%
Bronchodilators, bronchial hygiene therapy
and diuretic therapy decreases the need for
high FiO2