Palmitoylethanolamide supplement – How does Palmitoylethanolamide (PEA) work for the pain?

The synthetic drug, called ultramicronized palmitoylethanolamide (micro PEA), is believed to act as an anti-inflammatory. Palmitoylethanolamide (PEA) is a “a naturally occurring fatty acid” similar to an endocannabinoid, one of a suite of molecules found in cannabis in that targets CB2 receptors. CB2 receptors are thought to modulate both inflammation and pain throughout the human body.

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Palmitoylethanolamidesupplement-HowdoesPEA
workforthepain?
Reproducefrom:
https://www.phcoker.com/palmitoylethanolamide-pea/
Palmitoylethanolamidesupplement-HowdoesPEAworkforthepain?.............................................1
Palmitoylethanolamide(PEA)overview.................................................................................................2
WhatisPalmitoylethanolamide(PEA)?.................................................................................................3
Palmitoylethanolamidebenefits-WhatisPalmitoylethanolamideusedfor?......................................4
i.Supportsbrainhealth.......................................................................................................5
ii.RelievefrommultiplepainandInflammation.................................................................5
iii.Helpsreducethesymptomsofdepression....................................................................6
iv.Itrelievesthecommoncold...........................................................................................7
v.Lowersthesymptomsofinsular(multiple)sclerosis......................................................8
vi.Palmitoylethanolamideimprovesmetabolism...............................................................8
vii.Palmitoylethanolamidecanloweryourappetite..........................................................9
viii.Palmitoylethanolamideanti-inflammatoryeffectsduringexercise.............................9
WhoshouldtakeasupplementofPalmitoylethanolamide(PEA)?.....................................................10
WhatisPEAderivedfrom?.........................................................................................................10
DoesPEAgetyouhigh?..............................................................................................................11
IsPEAsupplementsafe?.............................................................................................................12
WhatarethesideeffectsofPEA?.....................................................................................12
IsPalmitoylethanolamidesafeinpregnancy?...................................................................13
Palmitoylethanolamidehalflife-Howlongdoesittakeforpeatowork?................................13
HowdoesPEAworkforpain?..............................................................................................................13
WhatisPEAforpainrelief?........................................................................................................14
IsPeaanantiinflammatory?.............................................................................................14
Ispeagoodforarthritis?...................................................................................................15
Whatarethebestpainkillersfornervepain?............................................................................15
HowcanItreatnervepainathome?................................................................................15
IsPalmitoylethanolamideacannabinoid?...........................................................................................16
IsPeaanendocannabinoid?.......................................................................................................18
Palmitoylethanolamide(PEA)andAnandamide.........................................................................18
PalmitoylethanolamideVSPhenylethylamine............................................................................19
HowdoItakePalmitoylethanolamide(PEA)supplement?.................................................................19
WheretobuyPalmitoylethanolamide(PEA)powder?...............................................................20

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Palmitoylethanolamide(PEA)overview
ThereisareportedthatFoodandDrugAdministrationapprovedtosubmitan
applicationforaclinicaltrialtotreatCOVID-19byusingasyntheticdrugthatmimics
theactionofamoleculefoundinmarijuana.
Thesyntheticdrug,calledultramicronizedpalmitoylethanolamide(microPEA),is
believedtoactasananti-inflammatory.Palmitoylethanolamide(PEA)isa“anaturally
occurringfattyacid”similartoanendocannabinoid,oneofasuiteofmoleculesfound
incannabisinthattargetsCB2receptors.CB2receptorsarethoughttomodulate
bothinflammationandpainthroughoutthehumanbody.
Since[microPEA]hasbeenusedinEuropefor20years,someItalianhealth-care
providerswereadvocatingtheuseofmicroPEAtotreatCOVID-19patientsandthey
werediscoveringsomesuccess.
SevereCOVID-19ischaracterizedbyanover-exuberantinflammatoryresponsethat
mayleadtoacytokinestorm.“microPEAisnotaviruskiller,buttheybelieveitcan
mitigatethatimmuneresponse,whichcanbefatal.

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WhatisPalmitoylethanolamide(PEA)?
Palmitoylethanolamide(PEA)isalipidthatoccursnaturallyinourbodyinthe
categoryoffattyacidamide.Itishenceanendogenouslipid.PEAisalsonaturally
producedinplantsandanimals.
Palmitoylethanolamide(PEA)canbefoundinfoodsuchasmilk,soybeans,garden
peas,soylecithin,meat,eggsandpeanuts.
NobelPrizewinnerLevi-MontalciniidentifiedPalmitoylethanolamide(PEA)asa
naturallyoccurringmolecule,describingitsvalueintreatingchronicinfectionsand
pains.Followingherdiscovery,hundredsofscientificstudieshavebeencarriedoutto
showthatitisveryeffectiveandsafetouse.Palmitoylethanolamide(PEA)is
describedinscientificwritingsasanaturalpainkiller.

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Palmitoylethanolamidebenefits-Whatis
Palmitoylethanolamideusedfor?
Palmitoylethanolamide(PEA)isafattyacidamideandissynthesizedandactsinside
ourbodyforregulationofvariousfunctions.Itisanendogenousfattyacidamide,
belongingtotheclassofnuclearfactoragonists.Palmitoylethanolamide(PEA)has
actuallybeenactuallywidelydiscoveredinalotsofinflammatoryanimalmodels,
alongwithinseveralmedicaltests.
Itisanaturalpainkillerandcanbeusedforchronicpainandinflammation.Italso
exertssomeotherbeneficialeffectlikeneuropathicache,fibromyalgia,several

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sclerosis,repetitivestraininjury,infectionsoftherespiratorytract,andmanyother
disorders.
Someofthereportedpalmitoylethanolamidebenefitsinclude;
i.Supportsbrainhealth
Palmitoylethanolamidebenefitsinenhancingbrainhealthareassociatedwithits
abilitytofightneuralinflammationandalsopromotionofneuralcellssurvive.Thisis
notedmorewithpeoplesufferingfromneurodegenerativedisordersandstroke.
Forinstance,inastudyof250peoplesufferingfromstroke,palmitoylethanolamide
supplementadministeredalongwithluteolinwasfoundtoenhancerecovery.PEA
wasfoundtoenhancememory,thegeneralbrainhealthaswellasdaytoday
functioning.Theseeffectsofpalmitoylethanolamidepowderwerenoticed30days
aftersupplementationandincreasedoveronemoremonth.
ii.RelievefrommultiplepainandInflammation
Scientistsprovideconsiderableevidencesofpalmitoylethanolamidepainrelieving
properties.Asamatteroffact,palmitoylethanolamideofferspainrelieftodiverse
typesofpainandinflammation.Somestudiesthatdemonstrates

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palmitoylethanolamidepainreliefpropertiesare;
Inastudyinvolvinganimals,palmitoylethanolamidesupplementalongwithquercetin
wasfoundtoofferrelieffromjointpainaswellasimprovethejointfunctioningand
protectionofcartilagefromdamage.
SomepreliminarystudiesshowthatPEAcanhelpreducenervepainsindiabetic
patients(diabeticneuropathy).
Inanotherstudywith12people,apalmitoylethanolamidedosageof300and1,200
mg/daygivenforabout3to8weekswasfoundtolowertheintensityofchronicand
neuropathicpain.
Astudyof80patientssufferingfromFibromyalgiasyndromefoundoutthatPEAin
additiontoothermedicinesforthedisorderpotentiallylowerthepain.
Further,severalotherstudiesshowthepalmitoylethanolamidepainreliefpotential
includingrelievefrompelvicpain,sciaticpain,backpain,cancerpainamongothers.
iii.Helpsreducethesymptomsofdepression
PEAindirectlyinfluencesthereceptorsresponsibleformood.Somestudies

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demonstratepalmitoylethanolamideanxietyreliefasakeyroleinfightingdepression.
Inastudyof58patientswithdepression,palmitoylethanolamidesupplementat1200
mg/dayalongwithantidepressantmedication(citalopram)administeredfor6weeks
wasfoundtosignificantlyimprovethemoodandthegeneraldepressionsymptoms.
iv.Itrelievesthecommoncold
Palmitoylethanolamidebenefitsincombatingthecommoncoldliesinitsabilityto
destroythevirusresponsibleforthecommoncold(influenzavirus).Surprisingly,the
commoncoldoccurswidelyandaffectsalmosteverybodyespeciallypeoplewith
comprisedimmunity.
Astudywith900youngsoldiersdemonstratedthatapalmitoylethanolamidedosage
of1200mgperdayreducedthetimetakenbytheparticipanttohealfromthecold
andalsothesymptomssuchasheadaches,feverandsorethroat.

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v.Lowersthesymptomsofinsular(multiple)sclerosis
Withtheprovenpalmitoylethanolamideanti-inflammatoryproperties,PEAis
undoubtedlysuitablefortreatingmultiplesclerosis.
Inastudyof29patientssufferingfromadvancedmultiplesclerosis,PEAaddedtothe
standarddoseofinterferonIFN-β1awasfoundtolowerthepainaswellasenhanced
thepatients’qualityoflife.
vi.Palmitoylethanolamideimprovesmetabolism
Palmitoylethanolamide(PEA)isabletobindtoPPAR-α,areceptorresponsiblefor

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metabolism,appetite,weightlossandfatsburning.WhenthePPAR-αreceptoris
triggeredyouexperiencehighenergylevelswhichhelpsthebodyburnmorefatsin
exerciseshenceyouloseweight.
vii.Palmitoylethanolamidecanloweryourappetite
Palmitoylethanolamideweightlosspotentialisdemonstratedinitsabilitytoinfluence
yourappetite.Similartoenhancingthemetabolism,whenthePPAR-αreceptoris
activateditleadstoafeelingoffullnesswhileeatingthushelpsyoucontrolthe
amountofcaloriesconsumed.
Further,PEAisconsideredafattyacidethanolamidesthatplaysakeyroleinfeeding
behavior.Inastudyofoveriectomizedratswithhighweightgain,PEAsupplementat
30mg/kgbodyweightfor5weekswasfoundtosignificantlylowertheirfoodintake,
fatmassandconsequentlythebodyweight.
viii.Palmitoylethanolamideanti-inflammatoryeffectsduringexercise
Onemayexperiencepainandinflammationduringandafterworkoutsdueto
excessiveweight.Well,PEAsupplementcouldhelppreventthisbystimulating
anti-inflammatoryactivityofthePPAR-αreceptor.Palmitoylethanolamidecanalso
inhibitthereleaseofinflammatoryenzymesinthebythehumanadiposetissues.

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Whoshouldtakeasupplementof
Palmitoylethanolamide(PEA)?
Palmitoylethanolamide(PEA)supplementisfitforallsufferingfromadversepainor
inflammationandalsoanyoneinterestedinweightlosswhetheronmedicationornot.
PEAhasbeenseentoenhancetheefficacyofotherdrugs.Itisanoptionforthose
whodonotfindreliefinusingtheprescribedpainkillers.
Palmitoylethanolamideanxietyreliefisanexcellentattributeanyoneatriskof
depressionorsufferingfromdepressionshouldtakePEAfor.
Furthermore,onewouldreapmoreofthePEAfromsupplementssince
manufacturersseekformulationsthatincreasespalmitoylethanolamidebioavailability
inyourbody.
WhatisPEAderivedfrom?
PEAisnaturallyproducedinourbodiesandalsobyanimalsandplants.However,for
peoplewithchronicpainorinflammation,PEAoccursininsufficientamounthence

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theneedforPEAsupplements.
Palmitoylethanolamidecanbederivedfromfoodsourcesrichinproteinssuchasmilk,
meat,soybeans,soylecithin,peanutsandgardenpeasamongothers.However,the
PEAobtainedfromfoodsourcesisinsmallamounts.Thismakes
palmitoylethanolamidebulkproductionnecessarytomeetthisdietaryneeds.
DoesPEAgetyouhigh?
PhenethylamineandPalmitoylethanolamidebothcancallPEA,buttheytotally
differentproducts.
Phenethylamine(PEA)isanorganiccompound,naturalmonoaminealkaloid,and
traceamine,whichactsasacentralnervoussystemstimulantinhumans.
Phenethylaminestimulatesthebodytomakecertainchemicalsthatplayarolein
depressionandotherpsychiatricconditions.
Takenindosesof500mg-1.5gperdosage,everyfewhours,PEAprovidestheusera
feelingofeuphoria,energy,stimulation,andoverallwellbeing.
However,pleasekindlynotethatPhenethylamine(PEA)isnotPalmitoylethanolamide
(PEA).PhenethylaminesupplementshavenotbeenapprovedbytheFDAformedical
use.Palmitoylethanolamide(PEA)isanaturalsubstanceproducedbythebody;itis

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veryeffectiveandsafetouseasasupplementforpainandinflammation.
IsPEAsupplementsafe?
Palmitoylethanolamide(PEA)isanaturalsubstanceproducedbythebody;itisvery
effectiveandsafetouseasasupplementforpainandinflammation.Noadverse
palmitoylethanolamidesideeffectshavebeenreportedaswellasnoadverse
interactionswithotherdrugs.
WhatarethesideeffectsofPEA?
Therearenoserioussideeffectsordrug-druginteractionshavebeenreportedsofar.
Palmitoylethanolamidecanbetakentogetherwithanyothersubstance.Itenhances
thepain-relievingeffectofclassicanalgesicsandanti-inflammatories.

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IsPalmitoylethanolamidesafeinpregnancy?
Nottobeusedbypregnantwomen.
Palmitoylethanolamidemayhelpnutritionallyaddressinflammationandchronicpain.
Itshouldonlybetakenundermedicalsupervision.
Palmitoylethanolamidehalflife-Howlongdoesittakeforpeatowork?
Palmitoylethanolamide(PEA)canbetakentogetherwithotherpainmedicationor
alone,asadvisedbyyourhealthcareprofessional,tosupportpainrelief.
Effectivenessforpainreliefis8hr
Resultsvariable;resultswithin48hrinsomepeople,butusefor8weeksfor
maximumresults,canbeusedlongtermforchronicneurologicalpain.
HowdoesPEAworkforpain?
ResearchhasshownthatPEApossessesanti-inflammatoryandanti-nociceptive
propertiesandtakingitregularlymayboostyourbody'snaturalresponsetopainby
dampeningtheresponseofthenervoussystemcellswhichcausepain.
Palmitoylethanolamidealsoworksindirectlytoinducetheactivitiesofsome
receptorssuchasthecannabinoidreceptors.PEAindirectlystimulatesthe

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cannabinoidreceptors(CB1andCB2)byactingasenzyme(FAAH-fattyacidamide
hydrolase)involvedinthebreakdownofthecannabinoidanandamide.Thishelpin
raisingthelevelsofanandamideinourbodies,whichisresponsibleforrelaxationand
combatingpain.
WhatisPEAforpainrelief?
Palmitoylethanolamide(PEA)isanaturalsubstanceproducedbythebody;itisan
endogenousfattyacidamide,belongingtotheclassofnuclearfactoragonists,and
canbeusedasasupplementforpainandinflammationtreatment.PEAisanatural,
protective,fattymoleculeproducedinourbody,helpingsupportthemyelinnerve
sheathsforgoodnervefunction.
PEAisafattyacidthatisinvolvedinvariouscellularfunctionsininflammationand
chronicpain,andhasbeenshowntohaveneuroprotective,anti-inflammatory,
anti-nociceptive(anti-pain)andanti-convulsantproperties.Italsoreduces
gastrointestinalmotilityandcancercellproliferation,aswellasprotectingthe
vascularendotheliumintheischemicheart.Ofteninpeoplewithchronicdisorders,
thebodydoesnotproduceenoughPEA,thusbytakingPEAtosupplementthebody’s
shortageismaybebeneficialinhelpingtotreattheseconditions.
IsPeaanantiinflammatory?

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Palmitoylethanolamide(PEA)isaninterestinganti-inflammatorytherapeutic
substanceandmightalsoholdgreatpromiseforthetreatmentofanumberof
(auto)immunedisorders,includinginflammatoryboweldiseaseandinflammatory
diseasesoftheCNS.
Ispeagoodforarthritis?
Palmitoylethanolamide(PEA)offersbenefitforarthritisbothinregardstoreducing
thedevelopmentandmaintenanceofchronicpainbutalsotohelplimittheprogress
ofjointdestructionassociatedwitharthritis.
Whatarethebestpainkillersfornervepain?
PEA(palmitoylethanolamide)hasbeenaroundsincethe1970’sbutisgaininga
reputationasanewagentintreatinginflammationandpain.Nodruginteractionsor
serioussideeffecthavebeenidentified.
PEAhasdemonstratedeffectivenessforchronicpainofmultipletypesassociated
withmanypainfulconditions,especiallywithneuropathic(nerve)pain,inflammatory
painandvisceralpainsuchasendometriosisandinterstitialcystitis.
HowcanItreatnervepainathome?
PEAisafattymoleculethathelpssupportthemyelinnervesheathsforgoodnerve

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function.
DeficiencyofvitaminsfromtheBgroupcannotonlycausenervepain,butalso
increasesit.
Additionalunpleasantsymptomscouldalsooccur,suchasawobblygait,tinglingand
stingingofthehandsandfeet,afeelingasifoneiswalkingonbarbedwireorcotton
woolorevennumbnessofthe
handsandfeet.
ToolittlevitaminB1leadstodisturbanceinthefunctioningofthenervesand
consequentlytoneuropathyandnervepain.WhenaddingvitaminB1,thepain
decreasesandthenervefunctionimproves.VitaminB1canbetakentogetherwith
PEA,thisprovidesoptimalsupporttothefunctioningofthenerves,preventsnerve
painorworseningpains.Recentstudieshaveshownthatmanypeoplewithchronic
pain,elderlypeopleanddiabeticshaveaninadequateamountofthesevitaminsin
theirblood.Thisisoneofthereasonsthatthesepeoplecannotbetreatedonlywith
painkillers;theyneed
morethanthat.PEAplusBvitaminssupportsthenervousandimmunesystemsin
casesofnervepain.
IsPalmitoylethanolamideacannabinoid?
CBD(Cannabidiol)isacompoundsextractedfromhempandmarijuana.Whilethe

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bodyproducescannabinoidsnaturally,CBDhasbeensupplementedtomeetthe
need.
Cannabinoidsarethebiologicalactivechemicalsproducedinthebodythatare
responsibleformemory,pain,appetite,andmovement.Scientistsspeculatethat
cannabinoidsmaybebeneficialinreducinginflammationandanxiety,destroying
cancercells,offeringrelaxationinmusclesandalsoenhancesappetite.
PEAisafattyacidamidealsoproducedinthebodyandcanbereferredtoasa
cannabimimetic.ThismeansitmimicstheworksofCBDinyourbody.
BothCBDandPEAactsindirectlybyinhibitingthefattyacidamidehydrolase(FAAH),
whichusuallybreakdownanandamideandweakensit.Thisresultstohighlevelsof
anandamide.Anandamideplaysamajorroleinthemoodandalsomotivation.The
increasedlevelsofanandamidepositivelyinfluencetheendocannabinoidsystem.
PEAhasgainedpopularityandcompeteswithCBD.PEAisconsideredasafe
alternativetoCBDduetothelegalissuesfacingitandalsothefactthatmostpeople
cannottoleratethehighlevelsof‘stone’thatcomeswiththeCBD.
Further,PEAismuchcheaperthanCBD.However,PEAcanbeusedinadditiontoCBD
toachievesynergeticeffects.

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IsPeaanendocannabinoid?
NO,Palmitoylethanolamide(PEA)isanendocannabinoid-likelipidmediatorwith
analgesicandanti-inflammatoryproperties.PEAsupportstheECSviamodulating
endocannabinoidsignalingandindirectlyactivatingcannabinoidreceptors.
Theendocannabinoidsystem(ECS)isanimportantbiologicalsystemthatregulates
andbalancesawiderangeofphysiologicalfunctionsinthebody.ResearchontheECS
hasledtotheidentificationofnotonlyendocannabinoidssuchasanandamide(AEA)
and2-arachidonoylglycerol(2-AG),butalsoendocannabinoid-likelipidmediators
suchaspalmitoylethanolamide(PEA).Theseendocannabinoid-likecompoundsoften
sharethesamemetabolicpathwaysofendocannabinoidsbutlackbindingaffinityfor
theclassicalcannabinoidreceptortype1andtype2(CB1andCB2).
Palmitoylethanolamide(PEA)andAnandamide
Palmitoylethanolamideandanandamidearecloselyrelatedsincetheyareboth
endogenousfattyacidamideproducedinthebody.
PEAandanandamidearesaidtohavesynergisticeffectsintreatmentofpainandalso
enhancethepainkillersused.
Theyarealsobrokendownbythefattyacidhydrolaseenzymeinthebody,hencethe

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effectsachievewhenusedtogetherismorethanwhenusedonstandalone
supplement.
PalmitoylethanolamideVSPhenylethylamine
Phenethylamineachemicalsubstancethatisnaturallyproducedbythebody.Itis
widelyusedforenhancingathleticperformanceandalsocanhelprelievedepression,
aidinweightlossandenhancemood.
Palmitoylethanolamideontheotherhandisafattyacidamidethatislargelyknown
forpainandinflammationrelief.
Thesetwocompoundsarenotrelated.Theonlythingthatconnectsthemisthatthey
arebothabbreviatedasPEA.
HowdoItakePalmitoylethanolamide(PEA)
supplement?
Whileweemphasizedthepalmitoylethanolamideanti-inflammatorybenefitamong
otherbenefits,itisworthbringingtoyourattentionsomemorefactsaboutPEA.PEA
occursinlargeparticlesandisinsolubleinwater,thismakespalmitoylethanolamide

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bioavailabilityandabsorptionlimited.
Thegoodnews,however,isthatmanufacturerstargetformulationsthatenhance
palmitoylethanolamidebioavailabilityformaximumutilizationinyourbody.Forthese,
PEApowderareavailableinnormalpowderformandmicromizedpowderform.
WheretobuyPalmitoylethanolamide(PEA)powder?
We’reinaninterestingerawhereonlinestoreshavebecomeaonestopshopfor
everythingincludingpalmitoylethanolamidebulksupplies.Ifyouconsidertaking
PEA,researchwidelyforlegitpalmitoylethanolamidebulksupplementmanufacturers.
Mostusersofpalmitoylethanolamidebuyitfromonlinestoresandshouldconsider
theirreviewsforthebestPEApowderinthemarket.
Abbreviations
AEA:Anandamide
CB1:CannabinoidtypeIreceptor
CB2:CannabinoidtypeIIreceptor
CENTRAL:CochraneCentralRegisterofControlledTrials
FAAH:Fatty-acidamidehydrolase

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NAAA:N-acylethanolaminehydrolyzingacidamidase
NAE:N-acylethanolamines
PEA:Palmitoylethanolamid
PPARα:Peroxisomeproliferator-activatedreceptoralpha
PRISMA-P:PreferredReportingItemsforSystematicReviewsandMeta-Analysis
Protocols
VASPain:VisualAnalogScaleforPain
ECS:endocannabinoidsystem
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pain:ameta-analysis.PainPhysician2017;20(5):353-362.
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caseseries.JPainRes2012;5:437-442.
[4]KeppelHasselinkJM,KopskyDJ.Theroleofpalmitoylethanolamide,anautacoid,
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