Paracetamol (ACETAMINOPHEN)Preparation .

Paracetamol
History
Properties
Applications
Method

1. PARACETAMOL
(ACETAMINOPHEN)

2. GENERAL INTRODUCTION
•Very Famous Analgesic & Antipyretic
•First Time Sale In USA As Tylenol In 1955
•More Than 80 Brands All Over World
•About 173 Brands In Pakistan & More Than 70
Manufacturers
•500 Mg Tab. In 1955 In UK As Panadol
•Panadol Elixir In 1958
•Addition Into BP. In 1963

3. PHYSICAL PROPERTIES
•White , Odourless& crystalline powder with bitter taste
•Soluble in 7 parts of alcohol(95%) & 70 parts of water
•Solubility in solutions of alkali hydroxides
•Insoluble in benzene & ether
•pH of solution is 6 and stable for 20 years

4. HISTORY OF PARACETAMOL
•Identification of antipyretic properties of aniline &
acetanilide in 1886 by Conn & Heppner
•Recommendation of napthalenefor worms by Prof.
strassburgin 1880 & mistake of pharmacy
•Derivatives synthesis of acetanilide by bayers
•Synthesis of paracetamolby joseph von Meringin 1893

5. SYNTHESIS OF PARACETAMOL
•STEP-I : NITRATION OF PHENOL

6. SYNTHESIS OF PARACETMOL
•STEP-II : REDUCTION OF NITRO TO AMINO
GROUP

7. SYNTHESIS OF PARACETMOL
STEP-III : FORMATION OF AN AMIDEOH
NH
2
OH
HN
C
O
CH
3
Ethanoic anhydride
Room Temp
Paracetamol