Parathyroid hormone

1. Parathyroid hormone
Dr. Sadaf Mumtaz
03/03/11

3. What is the role of Kidneys?
•Preventing reprecipation of Calcium freed
from bones
•Enhance activation of Vit D
What is the role of intestine?

4. Mechanism of action
•hPTH/PTHrP receptor
•PTH-2
•CPTH
•Pseudohypoparathyroidism
Adenylyl cyclase
PLC

5. Negative feed back loops
•Calcitonin plays a role in skeletal integrity in pregnancy or breast feeding
•Gastrointestinal hormones

7. Causes of hypophosphatemia
•Respiratory alkalosis
•Alcohol abuse
•Malabsorption
•Phosphaturia
–Primary renal dysfunction
–Diuretics
–Hyperparathyroidism

9. Pathophysiology
•Hypoparathyroidism
–Osteocytes
–Osteoclasts
–Rx
•Primary Hyperparathyroidism
–Osteoclasts
–Osteoblast----alkaline phosphatase
–Effects of hypercalcemia
–Parathyroid poisoning and metastatic calcification
–Kidney stones

10. Secondary hyperparathyroidism
•Difference
•Vit D deficiency
•Chronic renal disease

11. Tapping the facial nerve at the angle of jaw
in a patient with moderate hyposecretion
of a particular hormone elicits a
characteristic grimace on that side of the
face. Which endocrine abnormality could
give rise to this so called ‘Chvostek sign’ ?

12. Thanks