Part 2 Main Line of Treatment of Mastitis in Farm Animals Prof Dr Hamed Attia.pdf

main line

1. Part 2:Main Line of Treatment of Mastitis
in Farm Animals

2. ىناثلا ءزجلا: ةعرزملا تاناويح ىف عرضلا باهتلا جلاعل ةماعلا طوطخلا
ا.ةيطع دماح د
ناويحلا بط ذاتسا–ىرطيبلا بطلا ةيلك
قيزاقزلا ةعماج-رصم
ىنفلا راشتسملا
ةيرطيبلا ةيودلأل ضايرلابربخلا اجيموا ةسسؤمب

3. 5-Main Lines of Treatment of Mastitis
A-Coliform Mastitis in Cattle

4. First Aid
عرضلا باهتلا تلااح عم لماعتلل ةيلوأ تاوطخ

8. First aid once mastitis has been detected
❖Applying ice cubes on the udder surface.
❖The infected milk from infested teat should be drained out thrice a
day and safely disposed.
❖A composition of 5% phenol can be included to the infected milk to
ensure hygienic disposal.
❖First milking healthy, non-infected cows and subsequently those
infected.
❖عرضلا حطس ىلع جلثلا تابعكم عضو.
❖نامأب هنم صلختلاو مويلا يف تارم ثلاث ةباصملا ةملحلا نم باصملا بيلحلا فيرصت بجي.
❖ لونيفلا نم ةبيكرت ةفاضإ نكمي5 %هنم يحصلا صلختلا نامضل باصملا بيلحلا ىلإ.
❖ةباصملا راقبلأا مث نمو ةباصملا ريغو ةميلسلا راقبلأا بلح ًلاوأ.

9. First aid once mastitis has been detected
❖The infected and non-responsive quarter
should be dried up, permanently.
❖Calves should be prevented from suckling on
the infected teat.
❖مئاد لكشب ،بيجتسملا ريغو باصملا عبرلا فيفجت بجي.
❖ةباصملا ةملحلا نم ةعاضرلا نم لوجعلا عنم بجي.

10. Main Lines of Treatment of
Coliform Mastitis in Cattle

11. Line of
Treatment of
Coliform Mastitis
Anti-Inflamtory.
Antibiotic
Fluid
therapy
Vitamin
A&C
Oxytocine

12. 1-Antibiotics

13. Antibiotics used for
Treatment of Mastitis
1-systemic antibiotics
(given by the intramuscular
or subcutaneous route).
Intramammary
Antibiotics

14. ❖Intramammary antibiotics should be
the first-line treatment for cowswith mild
uncomplicated mastitis in a single quarter.
❖Systemic antibiotics should be used
when more than one quarter is affected.
❖ لخاد ةيويحلا تاداضملا نوكت نأ بجيعرضلا راقبلأل لولأا طخلا جلاع
ةفيفخلادحاو عبر يف دقعملا ريغ عرضلا باهتلا.
❖ ةيويحلا تاداضملا مادختسا بجي)ىلضع نقح)عبرلا نم رثكأ رثأتي امدنع.

15. Examples of antibiotics used for
treatment of Mastitis

16. LocalSystemic
Mastilex
(Gent
+Cephalo.)
Third generation of
cephalosporin
Snylox
Amoxicillin
+Clavunicacid
Neomastipra
Penicilline+Streptomycine
Pentomycin
Tetradelta
or Lincosin
Flurfinicol
Mastilex
(Gent Gentamycin

17. 2-Fluid therapy
1-Fluid Therapy (Specially in Coliform mastitis)
R/ Saline 0.9% 2-4 Liters مومسلا نم صلختلل ديرولا ىف نقحلل

18. 3-Antihistamic
3-Anti-histamincs

19. 4-Non stesiodal anti-inflammatry drugs
The NSAIDs used to treat bovine mastitis
include:
Flunixin meglumine
Meloxicam
Ketoprofen
Carprofen.

20. 5-Oxytocin
4-Oxytocin:
 R/ Oxytocin injection 3-4 ml I/V
5-Supportive therapy:
R/AD3E+ Vitamin C
R/I/V injection of glucose 25% → 1-2 liter

21. 6-Supportive therapy
5-Supportive therapy:
R/AD3E+ Vitamin C
R/I/V injection of glucose 25% → 1-2 liter

22. Important Notes

23. 3–5 days of systemically administered
benzylpenicillin treatment was efficient
against Staphylococcus aureus mastitis

24. Intramammary drugs tend to be best for
single quarter mild mastitis,
while systemic treatment is better for more
severe cases or multiple quarter infection.
ب ىفتكن دحاو عبر باهتلا تلااح ىف عرضلا نقاحمنقحلل ىعادلاو
ةيويحلا تاداضملاب ىلضعلا

25. Antibiotics approved for use in the udder
of dairy cows are effective in only 20–
50% of clinical mastitis

26. Effectiveness of systemic ceftiofur
in severe cases of mastitis showed a higher
survival rate of treated animals
with coliform mastitis

27. Bloody Milk Syndrome
سوماجلاو راقبلاا ىف ممدملا نبللا ةرهاظ

28. Bloody Milk Syndrome
سوماجلاو راقبلاا ىف ممدملا نبللا ةرهاظ
One quarter Four Quarter

29. One quarter
Inflamed udder
Mastitis
Not inflamed
❖Trauma
❖Edema after parturition

30. Four Quarter
Inflamed udder
Coliform mastitis
Not inflamed
❖Leptospira
❖Hypophosphatemia

32. Causes of Hemolactia(Blood in Milk) of Cows
The occurrence of pink-or red-tinged milk is common after
calving and can be attributed to rupture of small mammary
blood vessels.
Udder swelling from edema or trauma is a potential
underlying cause.
وعي نأ نوكميو ةدلاوولا دوعب اًعئاوش اًرومأ رومحلأا وأ أدروولا نووللا وذ بيلحلا روهظ دعي ىز
ةريغصلا ةييدثلا ةيومدلا ةيعولأا قزمت ىلإ.
 ًلامتحم اًيساسأ اًببس ةمدصلا وأ ةمذولا نع جتانلا عرضلا مروت دعي.

33. How we can deal with
Hemolactia(Blood in Milk) of Cows
In most cases, it resolves without treatment within 14 days,
provided the gland is milked out regularly.
Bright red milk from a single quarter is a sign of a larger
blood vessel hemorrhage or teat trauma, while dark brown
milk results from rupture of a major vein or severe mastitis.
 للاخ جلاع نود ةلكشملا لح متي ،تلااحلا مظعم يف14 طرشب ،اًموي ةيلمع رارمتسا
بيلحلاماظتناب.
يبكلا ةيومدلا ةيعولأا يف فيزن ىلع ةملاع وه دحاو عبر نم حتافلا رمحلأا بيلحلا وأ ةر
أ يسيئرلا ديرولا قزمت نع جتني نكادلا ينبلا بيلحلا نأ نيح يف ،ةملحلا ةمدص باهتلا و
ديدشلا عرضلا.

34. عبات
Milking should be discontinued until the
hemorrhage is controlled.
The likely cause of the mastitis should be
treated.
فيزنلا ىلع ةرطيسلا متت ىتح بلحلا فاقيإ بجي.
لمتحملا ببسلا ةجلاعم بجي

35. Treatment of Bloody Milk
Administration of hemostaticsand parenteral coagulants.
Intravenousadministrationof calcium borogluconateplus
magnesium and phosphorus can be used.
Epinephrine derivatives that hamper the flowofbloodby
vasoconstriction
5mlof1% solution of epinephrine canbe infused
intravenously.
Vitamin C preparations influence the blood clotting
mechanism.

36. 1-Bloody milk due to Leptospira
Clinical Signs
Flaccid udder & flappy
Blood come from all quarter
No inflammation of the udder
Has bloody urine

37. Main Line of Treatment of
Bloody milk due to Leptospira
R/Cefotaxime inj. 15ml/100 Kg I/V for 3 days
Or R/Streptomycine 5Gm I/M for 14 days
R/-I/M mammary infusion of epinephrine alone or with saline
(1 -2 amp.)
R/-I/V injection of Cal-D-Mag → 50-100 cm
R/ I/M injection of Vit.K→ amriK 1 amp. / 70 kg B.wt
4-Phosphorus preparation:
R/Phosphosal25Ml I/M for 5 days

38. 2-Treatment of Bloody milk due
to Phosphorus deficiency in buffaloes
R/-I/M mammary infusion of epinephrine alone or with saline
(1 -2 amp.)
R/-I/V injection of Cal-D-Mag → 50-100 cm
R/ I/M injection of Vit.K→ amriK 1 amp. / 70 kg B.wt
4-Phosphorus preperation:
R/Phosphosal25Ml I/M for 5 days

39. 3-bloody milk due to trauma
( blood only without milk )
R/Cefotaxime inj. 15ml/100 Kg I/V for 3 days
R/-I/M mammary infusion of epinephrine alone or with saline
(1 -2 amp.)
R/-I/V injection of Cal-D-Mag → 50-100 cm
R/ I/M injection of Vit.K→ amriK 1 amp. / 70 kg B.wt

40. Treatment 'failure'
There are four reasons why treatment does not result in
return to normal:
1. Wrong antibiotic :mastitis-causing organisms not killed
by the chosen treatment
2. Not enough antibiotics for long enough at the site of
infection -although bacteria are killed, not all are and return
after the end of treatment.
3. Re-infection :treatment works but cow gets re-infected.
4. Wrong cow :persistent damage to the udder can prevent
the antibiotic from coming into contact with the bacteria in
sufficient concentration.

42. Dry Cow Therapy

43. Dry Cow Therapy
The dry phase is an ideal time to treat mastitis with
antibiotic preparations with or without a teat sealant.
This treatment known as Dry Cow Therapy protects the
livestock against any intra-mammary infections (IMI) that
they may develop or may have contracted during the period
of lactation and provides a shield against new infections
during the dry period.

44. Dry Cow Therapy
Administer only approved commercial antibiotic products,
formulated specifically for dry cow therapy and available in
single-dose containers for intra-mammary infusion
Teat sealants may be selected for use in some cows and
some herds
Ensure a reduction in nutrient intake of cows one to two
weeks before drying off

45. Dry Cow Therapy
Numerous commercial products are available for dry cow
treatment and include penicillin, cloxacillin, cephapirin,
ceftiofur, or novobiocin.
One tube per quarter is sufficient and should be
administered immediately after the last milking of lactation.

46. ❖Dry cow therapy is one of the key measures of
controlling mastitis.
❖Selective Dry Cow Therapy is becoming more popular
as dairy equipment, Udder and stable hygiene improve.

47. ❖Dry cow therapy is one of the key measures of
controlling mastitis.
❖Selective Dry Cow Therapy is becoming more popular
as dairy equipment, Udder and stable hygiene improve.

48. 2-Main Line of treatment of Contagious
Agalactia in sheep & goats

49. Main Line of Treatment

50. 1-Antibiotic
Antibiotics can result in clinical improvement, but they
may not be effective in some chronic cases.
Fluoroquinolones, tetracyclines and macrolides are the
most commonly used agents.
Tylosinor oxytetracycline
Susceptibility to individual drugs may differ between
organisms.
Treatment may not eliminate the infection from carriers.

51. Antibiotic used for treatment of Mycoplasma
◼.
No
te
s
Trad NameGenericNameGroup
Marbocyl 10%
Forcyl16%)
Enerofloacine
Marbofloxacin
Enrofloxacin ciprofloxacin
Danofloxacin
Fuoroquin
olones
Zuprevo
Tilmicosin
Draxin
Erythromycin
Tildipirosin 180 mg/ml )
•Tilmicosin
•Tulathromycin
•Erythromycin
Macrolides

52. Beta Lactam group
Antimicrobials that inhibit cell wall synthesis (eg,
penicillin) are not effective against contagious agalactia.

53. Control & prevention

54. Vaccination
In endemic areas, inactivated vaccines are used with
mixed success, and published data on their effectiveness is
scarce.
Some have provided protection from clinical disease.
يفوقطانملا،ةءوبوملامدختسُتتاحاقللاةلطعملاحاجنب،نيابتمامكنأنايبلاتا
ةروشنملالوحاهتيلاعفةردان.
دقورفوضعبلاةيامحلانمضارملأاةيريرسلا.

55. سيرت سكلااجأ ) امزلابوكيملا دض ميعطت )زعاملاو مانغلأل
لامعتسلإا يعاود:
اوبون دوض زعاوملاو ماونغلأل لاوعف نيوصحت ووه سيروت سكلااجأ ت
وأ اووووويتكلاجا اووووومزلابوكيم اهببوووووست يوووووتلا ىودوووووعلاب ةباوووووصلإا
سديوكيم امزلاب وكيم وأ ملاوكيرباك امزلابوكيم
ةعرجلا :2لم.
ءاطعلإا هقيرط:
دلجلا تحت نقحلا قيرط نع يطعت سيرت سكلااجأ.
ةيواحلا حتف درجمب روفلا ىلع مدختسا.
ز

56. Main Line of treatment of mastitis in camels

57. Main Line of treatment of Mastitis in Camel
❖Antimicrobial Therapy
❖Immunostimulant
❖Antioxidant Therapy
❖Supportive Therapy
❖Exercise

58. 1-Antibiotic
❖Amoxycillin& clauvonicacid
❖cephalexin, oxytetracycline, cloxacillin, gentamycin
followed by ciprofloxacin, kanamycin, neomycin
lincomycin, penicillin, ampicillin ,furazolidone
nitrofurantoin and spiramycin, erythromycin

59. 2-Antioxidant Therapy
❖: Vitamin E and Se therapy has given good results.
❖Daily feeding of Zn, Cu and Se for one month in camels
resulted in 40 % lower infections.
❖

60. 3-Immuno-stimulant Therapy
❖levamisole was also given S/C

61. 4-Supportive Therapy
❖Oxytocin can be given for clearing milk if milk let down
❖is incomplete due to pain etc.
❖Analgesics can be given to relieve pain.
❖Anti-inflammatory drugs can be given to relieve
inflammation. B-complex therapy can be given as
supportive therapy.
❖Ascorbic acid feeding resulted in clearance of subclinical
❖infections.

62. 5-Exercise
❖Giving moderate post calving exercise in terms of walking
to relieve edema and subsequently development of mastitis
may give fruitful results in terms of controlling the
infections

63. Odematous mastitis in camels

64. Causes
❖Edematous mastitis in camels is a managemental
❖problem, due to inadequate exercise after calving.
❖This inadequate exercise results in persistent post
parturient udder edema for longer periods and interferes
with the normal let down and milking process.
❖باهتلاعرضلايمذولايفلبلإا،ةلكشموهببسبمدعةسراممةضايرلادعبةدلاولا.
❖أدؤياذهنيرمتلاريغيفاكلاىلإرارمتساةمذوعرضلادعبةدلاولاتارتفللوطأ
لخادتيوعمةيلمعبيرستلابلحلاوةيعيبطلا.

65. Causes
❖Odematous condition of udder occurs more severe in dairy
camels compared to camels with only suckling calves.
❖The visible signs of inflammation included acute and
edematous swelling of the udder and formation of pus in
the mammary exudates resulting in a visible alteration of
the milk.
❖Congestion of udder at parturationis a physiological
phenomenon but it may be sufficiently severe to cause the
edema of the belly, udder and teats.

66. عرض باهتلا ةلاح جلاع
دصفلا ةيلمع ءارجا عم

67. Main Line of treatment of Mastitis in Camel
❖Feeding of Cu, Zn and Se was found effective in clearing
the infections.

68. لبلاا ىف عرضلا باهتلا جلاعل صخلم
Amoxycillin and cloxacillin + levamisole +
vitamin E and selenium were used,
could clear 100% of the infections due to
streptococci.

69. Prevention of Masititis

70. Mastitis Prevention
◼Proper Milking Techniques
◼Procedures, training, monitoring
◼Keep cows clean!
◼Proper Bedding
•Sand is the best bedding
•Organic bedding (sawdust, etc.) must be dry
•Stall sized to fit cows
•Tail docking
◼Nutrition
◼Vitamins and minerals
◼Milk contagious cows last
◼Maintain milking equipment

71. Control of Contagious Mastitis
◼Dip teats in germicide after pre and post
milking
◼Treat quarters with dry cow antibiotics at
end of lactation
◼Milking order
◼Individual cloth/paper towels to wash/dry
teats
◼Clean hands, gloves
◼Cull persistently infected cows
◼Minimize teat end lesions

72. Control of Environmental Mastitis
◼More difficult to control than the contagious
pathogens
◼ID source and remove (bedding, ponds, mud)
◼Clip udders
◼Milk only clean dry teats
◼Clean parlor, stalls, bedding
◼Pre-dip teats with germicide before milking –No
water
◼Keep cows standing after milking -feeding
◼Sterile infusion techniques (alcohol swab)

74. Questions?