Part 3 Postpartum Metritis in Farm Animals(Causes- Signs and Main Line of Treatment ) Prof Dr Hamed Attia.pdf

Part 3 Postpartum Metritis in Farm Animals(Causes- Signs and Main Line of Treatment ) Prof Dr Hamed Attia.pdf

1. Part 3: Postpartum Metritis in Farm Animals
(Causes-Signs and Main Line of Treatment(

2. ثلاثلا ءزجلا: باهتلايف ةدلاولا دعب محرلا
ةعرزملا تاناويح)بابسلأا-جلاعلا قرطو ضارعلأا)
ا.ةيطع دماح د
ناويحلا بط ذاتسا–ىرطيبلا بطلا ةيلك
قيزاقزلا ةعماج-رصم
ىنفلا راشتسملا
ةيرطيبلا ةيودلأل ضايرلابربخلا اجيموا ةسسؤمب

3. Post partum Diseases in Cattle
Metabolic, Digestive,
Disorders
Inflammatory Infectious
disorders
❖fatty liver.
❖ketosis
❖Milk Fever
Displacement
of the
abomasum.
Metritis Mastitis

4. Affection of the uterus
Metritis
Within 20 days
after parturition
Endometritis
After 20 days from
parturation
Septic
Metritis
Clinical
Metritis
Clinical Pyometra

5. Risk factors for Uterine Infection

6. Optimal Fertility in Dairy cows
Depends on completing several integrated physiological
processes in the first five weeks after parturition:
prompt involution of the uterus and restoration of a
receptive endometrium; resumption of ovarian cyclical
activity and ovulation of competent oocytes; and, control of
pathogenic bacteria in the uterus.
فلا تايلمعلا نم ديدعلا لامكتسا ىلع نابللأا راقبأ يف ىلثملا ةبوصخلا دمتعت ةيجولويس
ةدلاولا دعب ىلولأا ةسمخلا عيباسلأا يف ةلماكتملا:
رودلا طاشنلا فانئتسا ؛ةلبقتملا محرلا ةناطب ةداعتساو محرلل عيرسلا دادترلاا ضيبملل ي
ةصتخملا تاضيوبلا ةضابإو.
محرلا يف ضارملأل ةببسملا ايريتكبلا ىلع ةرطيسلاو

7. Risk factors for uterine infection
Include:
Retention of the placenta
Poor hygiene in the calving environment
Dystocia.
Dead calf & stillbirth
Twins
Difficult calving and a poor transition diet.

8. The risk factors
Mounting by infected bull.
Unhygienic practices at insemination
Hypocalcemia
Season and poor nutrition
Antibiotic therapy, hormones, antiseptics and
immune-modulators

9. Causes of Metritis

10. Causes
Pneumonvagina
Trauma or catheter endometritis
Retrovaginalfistula
Polluted semen
Unhygienic birth help
Vaginal or uterine prolapse
Retained placenta
Infectious diseases

11. The bacteria commonly associated with
Uterine disease
Escherichia coli
Arcanobacteriumpyogenes
Brucellosis
leptospirosis.

12. Difference between Metritis and endometritis

13. 1-Metritis

14. Metritis
It is inflammation of all uterine layers
(endometrium, myometrium and
perimetrium.
Metritis is isgenerally caused by bacterial
infection.

15. 1-Septic metritis
Cows having enlarged uterus, fetid watery red-brown
Vaginal discharge (VD)
Fever, and signs of systemic Illness within 21 after
parturition.
رمحم ينب نول وذ نتن يئام ،مخضتملا محرلا تاذ راقبلأا
تازارفاىمحو ةيلبهم
 للاخ ضرملا فيرعت متي21ةدلاولا دعب

16. 2-Clinical Metritis
Enlarged uterus and fetid watery red-brown VD without
signs of systemic illness within 21 DIM

17. 2-Endometritis

18. 1-Clinical Endometritis
It is a more superficial inflammation involving solely
the endometrium.
Clinical endometritis is characterized by the
presence of purulent (> 50%) uterine discharge after
21 DIM .

19. Pyometra
Pyometra is characterized by a pus filled uterus
in the presence of a corpus luteum (CL), a
closed cervix and failure to express estrus

20. Clinical Signs of Metritis

21. Clinical Signs of Metritis
An abnormally enlarged uterus
A foetidwatery red-brown or purulent uterine discharge
and may be associated with signs of systemic illness
(decreased milk yield, dullness or other signs of toxaemia)
and fever >39.5ᵒC.

22. Diagnosis
History
Clinical signs
Rectal temperature
Rectal examination
Vaginoscopy
Whiteside test
Uterine biopsy
Bacterial culture

23. Main Line of Treatment of Metritis

24. MainLine of
Treatment of
Metritis
Anti-Inflammtory.
Antibiotic Fluid Therapy
Supportiv
treatmentHormonal

25. Main Line of Treatment
A systemic broad-spectrum antibiotic that penetrates into
the infected uterus and is active against the metritis
causing bacteria.
Prostaglandins
Supportive treatments
Rehydration therapy
NSAIDs
propylene glycol.

26. 1-Antibiotics used for
Treatment of Metritis
1-systemic antibiotics
❖Ceftiofur hydrochloride (Excenel)
❖Cefitofurcrystalline-free acid
❖(Excede)Subcutaneously
2-Intrauterine infusion
❖Cephapirin benzathine
(Metricure)
❖oxytetracycline

27. محرلا قيرط نع جلاعلا ةقيرط

28. ❖Cows with metritis that have fever and
systemic signs should be systemically
treated with penicillin, oxytetracycline,
or ceftiofur.
❖• Cows with metritis without fever do
not require antibiotic treatment and can
be managed with hormones.

29. ❖ ىااامح نااام ينااااعت ياااتلاو محرااالا بااااهتلاب ةبااااصملا رااااقبلأا
يلاسنبلاب يماامن لكاشب لااعت نأ بجي ةيزاهج تاملاعو وأ ن
روفويتفيسلا وأ نيلكيسارتتيسكولأا.
❖ •ىاالإ جاااتحت لا ىاامح نود محراالا باااهتلاب ةباااصملا راااقبلأا
تانومرهلاب اهجلاع نكميو ةيويحلا تاداضملاب جلاع.

30. 2-Fluid therapy
1-Fluid Therapy (Specially in Coliform Metritis)
R/ Saline 0.9% 2-4 Liters مومسلا نم صلختلل ديرولا ىف نقحلل

31. 3-Non stesiodal anti-
inflammatry drugs
The NSAIDs include:
Flunixin meglumine
Meloxicam
Ketoprofen
Carprofen.
Flunixin
meglumine

32. 1-Prostaglandin
The benefit from PGF2α administration isbelieved to arise
from induction of estrus in cows having a PGF2α-
responsive corpus luteum; the estrus leads to physical
expulsion of bacterial contaminants and inflammatory
products.

33. Roll of Prostaglandin (PGF2a)
Stimulation of uterine contraction, which aids in expulsing
purulent uterine fluid and debris.
Stimulation of leukocytes and luteolysiswith induction of
an estrous cycle, which consequently reduces
progesterone and increases estrogen levels.
زيفحتضابقنا،محرلااممدعاسيىلعدرطلئاسمحرلايحيقلاهاياقبو.
زيفحتتايركمدلاءاضيبلاللحتلاويرفصلأانعقيرطزيفحتةرود،قبشممايدؤي
يلاتلابىلإليلقتنومرهنورتسجوربلاةدايزوتايوتسمنومرهنيجورتسلاا.

34. 2-Estrogen Hormone
Estrogen may affect the uterus in the following
ways:
• Stimulating uterine tone to aid in evacuating abnormal
uterine contents
• Increasing production of mucus that contains host
defense compounds.

35. Name of some drugs contain prostaglandin

36. Cloprostenol:
a synthetic analogue of
prostaglandin F2-alpha,
induces regression of the
corpus luteum and
stimulates follicular growth
and development during
the female sexual cycle’s
luteal phase.

37. Indication
❖Used to strengthen contractions
during complicated labor.
❖Accelerate uterine involution,
treat postpartum hemorrhage,
endometritis (in combination
with antibiotics).
❖Regress persistent corpus
luteum, resolve corpus luteum
cysts.
❖Stimulate/synchronize estrus
during insemination.

38. Dose:
Cows, heifers
For maternity complications:
R/ 2 ml per 400 kg of body weight.
R/Adjust dosage by 0.3 ml for
every 50 kg increase or decrease
in weigh

40. Indications:
❖Heat synchronization.
Parturition or abortion
induction.
❖Treatment of functional
disorders of the estrous
cycle and the ovary
(luteal or folicularcysts).
❖Treatment of post-
parturition uterine
pathologies (pyometra,
endometritis).

41. CONTRAINDICATIONS :لامعتسلاا عناوم
Avoid injecting in females during the first
trimensterof pregnancy to prevent abortion.
ضاهجلإا عنمل لمحلا نم ىلولأا ةثلاثلا رهشلأا للاخ ثانلإا نقح بنجت.

42. Complication of Untreated Endometritis

43. Complication of Untreated Endometritis
❖Pyometra
❖anestrous with
an extended luteal phase
❖Subfertility
or infertility

44. ECONOMIC IMPACT

45. ECONOMIC IMPACT
Prolonged days open, due to lower conception and estrus
detection rates.
Higher insemination costs, due to repeat artificial
insemination services.
Increased culling rate, resulting in higher replacement
costs.
Greater costs for veterinary interventions.
قبشلا فاشتكاو لمحلا تلادعم ضافخنا ببسب كلذو ،ةليوط ةحوتفم مايأ.
يعانصلا حيقلتلا ةيلمع راركت ببسب حيقلتلا فيلاكت عافترا.
لادبتسلاا فيلاكت عافترا ىلإ ىدأ امم ،مادعلإا لدعم ةدايز.
ةيرطيبلا تلاخدتلا فيلاكت عافترا.

46. Important Notes

47. Highlights
Up to forty percent of dairy cows develop metritis or
endometritis when pathogenic bacteria infect the uterus
after parturition.
It is unclear why the other sixty percent of dairy cows do
not develop uterine disease when exposed to similar
pathogenic bacteria after parturition.
اطب باهتلا وأ محرلا باهتلاب باصت نابللأا راقبأ نم ةئاملاب نيعبرأ ىلإ لصي ام محرلا ةن
ةدلاولا دعب محرلا ضارملأل ةببسملا ايريتكبلا بيصت امدنع.
ا ضارمأب نابللأا راقبأ نم ىرخلأا ةئاملاب نيتسلا باصت لا اذامل حضاولا ريغ نمو محرل
ةدلاولا دعب ةلثامم ةضرمم ايريتكبل اهضرعت دنع.

48. Highlights
We provide a perspective on the mechanisms that dairy cows use
to try to prevent the development of postpartum uterine disease.
We suggest that resilient dairy cows prevent the development of
uterine disease using the three complementary defensive strategies
of avoiding, tolerating and resisting infection with pathogenic
bacteria.
نحنمدقناًرومنملوحتايللآايتلااهمدختستراقبأنابللأاةلواحملعنمروطتضرممحرلابدع
ةدلاولا.
حرتقننأراقبأنابللأاةنرملاعنمتروطتضارمأمحرلامادختسابتايجيتارتسلااةيعافدلااةيليمكتل
ةثلاثلابنجتلىودعلاايريتكبلابةببسملاضارملألحماستلاواهعماهتمواقمو.

49. ةمهم تامحلام
Clinical metritis and puerperal metritis were associated with lower
milk yield in early lactation.
Puerperal metritis was related to lower early pregnancy
rate and extended calving to conception interval.
A therapy with ceftiofur was not associated with cure rate but was
related to increased pregnancy rate at TAI and reduced risk for
reproductive culling.
❖ةعاضرلا يف بيلحلا جاتنإ ضافخناب يسافنلا محرلا باهتلاو يريرسلا محرلا باهتلا طبتراةركبملا.
❖ ضافخناب اًطبترم يسافنلا محرلا باهتلا لدعمركبملا لمحلالمحلا ةرتف ىتح ةدتمملا ةدلاولاو.
❖داايزب ااًطبترم نااك انكلو ءافشلا لدعمب روفويتفيسلاب داعبلأا يثلاث جلاعلا طبتري مل ياف لامحلا لداعم ة
رطخ ليلقتوةضيرملا تلااحلل داعبتسلاا.

50. Management can help prevent postpartum uterine disease

51. ةلاحلا نسحت تاملاع
Considering normaltemperature and
non-fetid VD as criteria for cure.

52. Questions?