pH responsive polymers in polymer chemistry

pH responsive polymers in polymer chemistry science

1. Ministry of Higher Education and Scientific Research
University of Sulaimani
College of Science
Department of Chemistry









Prepared by:

hazhir esmail, bryar nahman, barez salah


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2. pH-sensitive polymers:
Respond to the changes in the pH of
surrounding medium, Polymers which
exhibit a physical response to their
environment, generally are
polyelectrolytes (i.e. have ionisable
groups), Can be based on polyacids or
polybases.

4. The physical properties of the polymer, such
as its chain conformation, configuration, and
solubility, can be tailored by manipulating
the pH or ionic strength.

6. This is very useful behavior, as the core may
by used to carry a payload (e.g. a drug)
which will then be released we it reaches a
certain pH environment.

8. One function of these polymers right now is
for use in targeted tumor treatment, by
targeting the tumor from inside the body,
medicine that could be harmful to healthy
cells is better contained in the area that needs
it.

9. pH‐sensitive polymers are widely used in the
fabrication of insulin delivery systems to
maintain glucose level. Since insulin has to be
delivered in a precise amount at the exact
time of need, insulin delivery systems need to
be carefully designed.

10. Living polymerization is often used for making
pH sensitive polymers because molecular weight
distribution of the final polymers can be
controlled. Examples include group transfer
polymerization (GTP)

Degree of swelling
Equal to (swollen weight-deswelled weight)/deswelled
weight *100% and determined by massing polymers
before and after swelling. This indicates how much
the polymer swelled upon a change in pH

Applications
Purification and separation
pH sensitive polymers have been considered for use in
membranes. A change in pH could change the ability of
the polymer to let ions through, allowing it to act as a
filter.
Biomedical Use
pH sensitive polymers have been used for drug
delivery. For example, they can be used to
release of insulin.
Surface modification
pH sensitive polymers have been used to modify
the surfaces of materials. For example, they can
be used to change the wettability of a surface.

11. Conclusion:


• pH sensitive polymers have the possibility
to do great things for some terrible
treatments by targeting the affected area
• •Polyelectrolytes can act as pH responsive
polymers providing they can act as weak
acids or bases
• •As the polymer is increasingly ionized, the
polymer expands owing to electrostatic
repulsion between charges.
• •pH responsive polymers have the
potential to be used to create a large
number of devices.

12. References:
1)Chaturvedi, Kiran; Ganguly, Kuntal; Nadagouda, Mallikarjuna
N.; Aminabhavi, Tejraj M. (2013-01-28). "Polymeric hydrogels
for oral insulin delivery". Journal of Controlled Release. 165 (2):
129–138.
2) Popescu, Maria-Teodora; Tsitsilianis, Constantinos;
Papadakis, Christine M.; Adelsberger, Joseph; Balog, Sandor;
Busch, Peter; Hadjiantoniou, Natalie A.; Patrickios, Costas S.
(2012-04-24). "Stimuli-Responsive Amphiphilic Polyelectrolyte
Heptablock Copolymer Physical Hydrogels: An Unusual pH-
Response". Macromolecules. 45 (8): 3523–3530.
3) Muzammil I, Li Y, Lei M. Tunable wettability and pH-
responsiveness of plasma copolymers of acrylic acid and
octafluorocyclobutane. Plasma Process Polym. 2017;e1700053
4) Meléndez-Ortiz, H Iván; H.C. Varca (2016. "State of the art of
smart polymers: from fundamentals to final
applications." Polymer Science: research advances, practical
applications and educational aspects. Formatex Research
Center. pp. 476-487.
5) Kocak, G.; Tuncer, C.; Bütün, V. (2016-12-20). "pH-Responsive
polymers". Polym. Chem. 8 (1): 144–176
6) Dupré de Baubigny, J., Trégouët, C., Salez, T., Pantoustier, N.,
Perrin, P., Reyssat, M. and Monteux, C. (2017). One-Step
Fabrication of pH-Responsive Membranes and Microcapsules
through Interfacial H-Bond Polymer Complexation. Scientific
Reports, 7(1).