Pharma pellet

pharmaceutical maunfacting pellet

1. Dr. SafiaA. Alrezami

2. Types of solid drug forms
TabletsCapsules
Sachets
Granules Powders

3. Тablets
A tablet is a solid dosage form that is prepared
by compressing or molding of the drug into
various sizes and shapes.
Types of tablets
Oral
administration
Vaginal
administration
Implantation
(pellets)

4. Pellets
1. Definition.
A small, sterile tablet used by implantation when prolonged
and continuous absorption is desired.
Multiple-Unit Pellet System (MUPS)
are a kind of multiparticulatesystem that has become an
important and successful dosage form for immediate or
modified drug release.
2.Size and shape
Range in size between (0.5-1.5mm)
Q1:What is the important of their size?
Allowance their administration as
injections and for oral drug delivery.

5. Types of pellets
Orally
Multiple-Unit
Pellet System
((MUPS
Implant
(pellets)
Example
contraceptive
Example
PPIs

6. Pellets
Masking taste
Fast (immediate release)
Sustained release

7. Pellets

8. Manufacturing of pellets
Methods of
processing
Master
formula
1.Pellet corn (starter seed):
API +Diluent(sugar).
2. Coating
Binder (liquid(water or glycerol) why?
To allow wet granulation.
(Other(lubricant, disintegrated agent

9. Methods of preparation
(pelletization)
Agitation
balling
Drug layering
I. Powder
II. Liquid
Suspension \solution
Globulation
I. Spray drying
II. Spray congealing
Compact
I. Extrusion-spheronization
II. Compression

10. 1.Agitation (balling)
It is known as spherical agglomeration .In this method,
particles are converted to spherical pellets by continuous
rolling or tumbling blender using a rotating drum or pan.
Now this method is limited.
Types
Liquid-induced
agglomeration
Melt -induced
agglomeration

11. Layering involves the deposition of
successive layers of dry powder or
liquid droplets of drug and binding
into inert seed.
2.Drug layering

12. 2. Drug
layering
Powder layers Liquid layer

13. Spray drying Spray congealing
Globulation

14. Compression
4.Compact

15. Extrusion-spheronization
4.Compact
New method
called hot melt
extrusion

16. Cryopelletization
NEW TECHANGIUES
A process whereby
droplet of a liquid
formulation are
converted into spherical
pellet by using liquid
nitrogen as fixing
medium .at 160
0
C

17. HOW IS ITUSED IN MEDICAL
FLIED ?

18. T
AH
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