Pharmaceutical Excipients and Formulation.pptx

This presentation provides an overview of pharmaceutical tablets and lozenges, highlighting key excipients, formulation types, and evaluation parameters. It covers common excipients such as binders, disintegrants, fillers, and coatings, explaining their roles in enhancing drug stability, delivery, and patient compliance. The presentation explores different tablet types—sublingual, buccal, and chewable—and medicated lozenges, detailing their advantages and disadvantages. Key evaluation tests, including weight variation, hardness, friability, and content uniformity, are also discussed to ensure quality and efficacy. The presentation emphasizes the critical role of excipients and evaluation parameters in optimizing pharmaceutical formulations for safe and effective drug administration.

1. Pharmaceutical Tablets: Excipients and Formulation A Comprehensive Overview Sweta Yadav Clinical Research Associate

2. Contents Common Excipients Sublingual Tablets Buccal Tablets Chewable Tablets Medicated Lozenges Evaluation Parameters

3. Common Excipients Definition: Pharmacologically inactive substances used as carriers for active ingredients. Purpose: Enhance absorption Bulking agents Improve stability and dosing Types of Excipients: Anti-adherents, Binders, Coatings Disintegrants, Fillers, Flavors Colors, Lubricants, Glidants Sorbents, Preservatives, Sweeteners

4. Types of Excipients (1/2) Anti-adherents: Prevent sticking of powders to punches (e.g., Magnesium Stearate 0.25-1.5%). Binders: Provide mechanical strength and volume (e.g., Lactose, Gelatin, PVP). Coatings: Protect tablets from moisture and improve swallowability (e.g., HPMC). Disintegrants: Facilitate tablet breakdown for absorption (e.g., Sodium Starch Glycolate 4-6%).

5. Types of Excipients (2/2) Fillers: Increase tablet size (e.g., Lactose, Calcium Carbonate). Flavors & Colors: Improve taste and appearance. Lubricants & Glidants: Reduce friction during manufacturing (e.g., Talc, Silica). Sorbents & Preservatives: Moisture-proofing and stability enhancers (e.g., Parabens). Sweeteners: Enhance palatability, especially for chewables .

6. Sublingual Tablets Objective: Absorption through mucosa for fast systemic effects. Advantages: Bypasses first-pass metabolism. Rapid absorption due to rich blood supply. Disadvantages: Taste issues, potential for swallowing, small dose requirement.

7. Buccal Tablets Purpose: Absorption through mouth lining; slower absorption compared to sublingual. Formulation: Typically flat or elliptical tablets. Example: Methyl Testosterone Buccal Tablets.

8. Chewable Tablets Purpose: Easier administration for children and elderly; not meant to be swallowed whole. Advantages: Better bioavailability, improved patient convenience. Disadvantages: Not suitable for bitter-tasting or irritant drugs. Examples: Multivitamins, Antacids.

9. Medicated Lozenges Definition: Flavored medicated forms intended to dissolve slowly in the mouth. Types: Hard candy and compressed lozenges. Advantages: Extended contact with oral cavity, easy administration. Disadvantages: Perception as candy by children.

10. Evaluation Parameters Weight Variation: Ensures uniformity of tablet weight. Hardness Test: Measures tablet strength. Friability Test: Tests tablet’s ability to resist breaking. Water Absorption Ratio: Determines moisture uptake. Wetting Time: Measures time taken for complete wetting of the tablet. Content Uniformity Test: Ensures consistent active ingredient distribution.

11. Conclusion Summary: Understanding excipients and tablet types is crucial in pharmaceutical formulations. Importance: Proper selection of excipients enhances drug delivery, stability, and patient compliance.

12. Thankyou