Pharmaceutical Plant Layout

Pharmaceutical plant layout describes distribution of space and arrangements of equipment in proper manner.,so as to do the work in a proper way.

1. M. Pharm Sem-I Presentations Pharmaceutical Plant Layout SUBMITTED TO SAVITRIB AI PHULE, PUNE UNIVERSITY , PUNE FOR PARTIAL FULFILMENT OF REQUIREMENTS FOR THE AWARD OF MASTER OF PHARMACY IN THE SUBJECT Pharmaceutical Manufacturing Technology IN THE FACULTY OF SCIENCE AND TECHNOLOGY Bhujbal Knowledge City, MET’s Institute of Pharmacy, Adgaon, Nashik, 422003. Maharashtra, India Academic Year : 2021-2022 1 Presented By- Bairagi Akshata A. Guided By - Dr. Sapna Ahirrao

2. Contents Introduction Features of Good Pharmaceutical Plant Layout General Requirements of Pharmaceutical Plant Principles of Plant Layout Types of Plant Layout Factors Affecting Plant Layout Special Provisions Of Plant Layout Production Planning Managing Risks Production Control Advantages Conclusions

3. Introduction 3 Pharmaceutical plant layout describes the distribution of space and the arrangement of equipment, furniture, and other significant administration and necessary services within a factory building to perform the various unit operations involved in the production of dosage forms in an efficient manner and with the least amount of handling in processing the product from the receipt of raw material through the distribution of the finished goods.

4. Features of Good Pharmaceutical Plant Layout 4 The following traits a successful pharmaceutical plant layout should have: Ample floor space should be available for machine installation and use. For low-cost processing, the equipment should be properly organized to allow for the least amount of material handling. Effective supervision, coordination, and control of the production processes should be possible with a proper layout. When necessary, there should always be an opportunity for change and correction.

5. General Requirements For Pharmaceutical Plant Pharmaceutical facilities must be positioned, planned, built, and maintained to accommodate the procedures to be performed. To reduce the possibility of mistakes and enable efficient cleaning, they must be laid out and designed in a way that prevents cross-contamination. Manufacturing facilities should be built in a way that makes it possible to maintain hygienic conditions at all times. For cleaning, maintenance, disinfection, and sanitization, SOPs and records should be kept. Plants should be kept in order Power supply lighting, temperature, humidity, and HVAC are all important factors.

6. Principles of Plant Layout

7. Types of Plant Layout 7 Three different plant layouts exist: Process flow Product design layout In a fixed place Process layout: Based on their operational features, similar machines are grouped together to form a process layout, also known as a functional layout or a batch production layout. Product layout: In product layout, also known as straight-line layout, equipment is arranged in a single line in accordance with the order of production processes. Fixed position layout: Products that are too huge, heavy, or fragile to move to a site for completion are put together in this type of facility layout.

8. Fig . Pharmaceutical Plant Layout For Aseptic Area

9. Factors Affecting Plant Layout the proposed company's location monetary considerations (cost) building a factory Product type Production method Production volume Equipment and machine types Machinery and equipment repairs and maintenance Needs of employees and safety conditions that affect plants

10. Production Planning Production planning is a process of converting a set of inputs such as men, capital, information, and energy into finished products. Steps involved in production planning

11. Production Planning Includes

12. Managing Risks Process of risk management - Rather than taking a reactive strategy, risk management is always proactive. The major goal of this strategy is to reduce the incidence and its detrimental effects on project time, cost, and quality. Clifford Gray and Eric W. Larson have broken down the risk management procedure into four steps: identification of risks risk evaluation development of risk responses Risk response management

13. Production Control It consists of two parts, progress reporting and corrective action It involves four stages :

14. Advantages of Good Pharmaceutical Plant Layout Maximum utilization of the floor area available for production activities. Decreased risk of cross-contamination leads to higher product quality. Efficient planning for raw materials and completed goods receipt, transportation, storage, and delivery. Low material handling costs. Increased output with a lower chance of human error.

15. Conclusions Considering that choosing medication is a long-term commitment, planning the layout is important. Additionally, it is a constant process because there is always room for development. It should be planned in such a way that the output, floor area, and manufacturing process all have the best possible relationships, making the plant's operation very efficient. Although the layout of pharmaceutical plants varies from plant to plant, the fundamental ideas behind pharmaceutical plant layouts are often the same.

16. References Manohar A. Potdar , Pharmaceutical Facilities, Second Edition, Pharma Med Press. Sheetal V. Patil , Dr. Md. Rageeb , PV, A Text Book of Pharmaceutical Manufacturing Technology, Vikas & Company (Medical Publishers), Page No.11-13. https://www.pharmapproach.com/pharmaceutical-plant-layout https://www.slideshare.net/anks2017/plant-layout-ppt