PPT Classes of Antihypertensive Agentspptx

powerpoint presenation on antihypertensive agents

1. introduction All anti hypertensive agent lower blood pressure although, The mechanism of action varies greatly.within this therapeutic class ,there are several sub groups.

2. Classes of Antihypertensive Agents Diuretics Peripheral a-1 Adrenergic Antagonists Central Sympatholytics ( a-2 agonists) b- Adrenergic Antagonists Anti- angiotensin II Drugs Ca++ Channel Blockers Vasodilators

3. DIURETICS Thiazides hydrochlorothiazide chlorthalidone Loop diuretics furosemide ( Lasix ); bumetadine , ethacrynic acid

4. CONT: K+ Sparing amiloride ; spironolactone ; triamterene Osmotic mannitol ; urea Other acetazolamide ( Diamox )

5. ActioN ACTION: They work by selectively blocking NACL transport in the distal convulated tubule as they bind to the cl dependent portion of the transporter .on the other hand they inhibit carbonic anhydrease in the proximal convulated tubule thus reducing solute overload in the DCT,and increasing K+ Passive excretion They work by selectively blocking NACL transport in the distal convulated tubule as they bind to the cl dependent portion of the transporter . on the other hand they inhibit carbonic anhydrease in the proximal convulated tubule thus reducing solute overload in the DCT,and increasing K+ Passive excretion

6. Peripheral a-1 Adrenergic Antagonists Drugs : prazosin . terazosin .

7. ACTION: Blocking - receptors on vascular smooth muscle allows muscle relaxation, dilation of vessel, and reduced resistance

8. Central Sympatholytics ( a -2 Agonists) Drugs : clonidine . methyldopa .

9. ACTION: Stimulation of a-2 receptors in the medulla decreases peripheral sympathetic activity, Reduces tone, vasodilation decreases TPR

10. b A drenergic Antagonists - Drugs: propranolol metoprolol atenolol nadolol pindolol

11. ACTION competitive antagonist at b- adrenergic receptors

12. Anti- Angiotensin II Drugs 1-Angiotensin Converting Enzyme- Inhibitors enalopril quinapril fosinopril moexipril lisinopril benazepril captopril 2-Ang II Receptor Antagonists losartan candesartan valsartan

13. Action: It decrease blood pressure by decreasing systemic vascular resistance improved cardiac output

14. Ca++ Channel Blockers Drugs : verapamil nifedipine diltiazem amlodipine

15. Action Blocks Ca++ channel decreases/prevents contraction Ca ++

16. Vasodilators Drugs : hydralazine . minoxidil . nitroprusside diazoxide . fenoldopam .

17. Action Vasodilation refers to the widening of blood vessel resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries , smaller arterioles and large vein

18. recaptualization Recaptualization - Enalopril come under ----------classification of anti hypertensives drugs.

19. -A B C D stand for….

20. Mechanism of action of Angiotensin 2 receptor Antagonist.