Ppt kanabis sebagai industri pengobayanbindonesia

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1. Bioprospek Kanabis sebagai Komoditas Industri dan Obat-obatan Oleh Musri Musman Guru Besar Kimia Bahan Alam USK

2. Scientific classification Kingdom: Plantae Division: Magnoliophyta Class: Magnoliopsida Order: Urticales Family: Cannabaceae Genus: Cannabis Species: C. sativa C. indica C. ruderalis C. sativa C. indica C. ruderalis https://contextout.blogspot.com/p/moses-used.html?m=1

3. MusriMusman/DP_ALSA/04032020 Industrial Advantages

4. 6 Evidence-Based Health Benefits of Hemp Seeds 1. Hemp Seeds Are Incredibly Nutritious Hemp seeds contain over 30% fat. They are exceptionally rich in two essential fatty acids, linoleic acid (omega-6) and alpha-linolenic acid (omega-3). They also contain gamma-linolenic acid, which has been linked to several health benefits (1). Hemp seeds are a great protein source, as more than 25% of their total calories are from high quality protein. That is considerably more than similar foods like chia seeds and flaxseeds, whose calories are 16– 18% protein. Hemp seeds are also a great source of vitamin E and minerals, such as phosphorus, potassium, sodium, magnesium, sulfur, calcium, iron and zinc (1, 2Trusted Source). Hemp seeds can be consumed raw, cooked or roasted. Hemp seed oil is also very healthy and has been used as a food and medicine in China for at least 3,000 years (1). SUMMARY Hemp seeds are rich in healthy fats and essential fatty acids. They are also a great protein source and contain high amounts of vitamin E, phosphorus, potassium, sodium, magnesium, sulfur, calcium, iron and zinc.

5. 1. Hemp seeds can help build muscle mass. Benefits of Hemp Seeds 2. They can boost energy. 3. They may help you lose weight. 4. Hemp seeds may keep you from getting hangry. 5. They'll help you sleep. 6. They can help correct anemia. 7. Hemp seeds may protect your ticker. 8. They might reduce PMS symptoms 9. Hemp could benefit the brain 10. Hemp could help boost the immune system Other Health Benefits People still use it as a remedy for many illnesses, though, including: Asthma Cough Bloating Arthritis Syphilis Pneumonia Heart problems Urinary conditions (increasing urine flow) Warts (when applied to the skin) Pain relief Hair and scalp care Premenstrual syndrome Pregnancy

6. 2. Hemp Seeds May Reduce Your Risk of Heart Disease Heart disease is the number one cause of death worldwide (3Trusted Source). Interestingly, eating hemp seeds may reduce your risk of heart disease. The seeds contain high amounts of the amino acid arginine, which produces nitric oxide in your body (4Trusted Source). Nitric oxide is a gas molecule that makes your blood vessels dilate and relax, leading to lowered blood pressure and a reduced risk of heart disease (5Trusted Source). In a large study in over 13,000 people, increased arginine intake corresponded with decreased levels of C-reactive protein (CRP), an inflammation marker. High levels of CRP are linked to heart disease (6Trusted Source, 7Trusted Source). The gamma-linolenic acid found in hemp seeds has also been linked to reduced inflammation, which may decrease your risk of diseases like heart disease (8Trusted Source, 9Trusted Source). Additionally, animal studies have shown that hemp seeds or hemp seed oil may reduce blood pressure, decrease the risk of blood clot formation and help the heart recover after a heart attack (10Trusted Source, 11Trusted Source, 12Trusted Source). SUMMARY Hemp seeds are a great source of arginine and gamma-linolenic acid, which have been linked to a reduced risk of heart disease.

7. 3. Hemp Seeds and Oil May Benefit Skin Disorders Fatty acids may affect immune responses in your body (13Trusted Source, 14Trusted Source, 15Trusted Source). Studies suggest that your immune system depends on the balance of omega-6 and omega-3 fatty acids. Hemp seeds are a good source of polyunsaturated and essential fatty acids. They have about a 3:1 ratio of omega-6 to omega-3, which is considered in the optimal range. Studies have shown that giving hemp seed oil to people with eczema may improve blood levels of essential fatty acids. The oil may also relieve dry skin, improve itchiness and reduce the need for skin medication (16Trusted Source, 17Trusted Source). SUMMARY Hemp seeds are rich in healthy fats. They have a 3:1 ratio of omega-6 to omega-3, which may benefit skin diseases and provide relief from eczema and its uncomfortable symptoms.

8. 4. Hemp Seeds Are a Great Source of Plant-Based Protein About 25% of calories in hemp seeds come from protein, which is relatively high. In fact, by weight, hemp seeds provide similar amounts of protein as beef and lamb — 30 grams of hemp seeds, or 2–3 tablespoons, provide about 11 grams of protein (1). They are considered a complete protein source, which means that they provide all the essential amino acids. Your body cannot produce essential amino acids and must obtain them from your diet. Complete protein sources are very rare in the plant kingdom, as plants often lack the amino acid lysine. Quinoa is another example of a complete, plant-based protein source. Hemp seeds contain significant amounts of the amino acids methionine and cysteine, as well as very high levels of arginine and glutamic acid (18). The digestibility of hemp protein is also very good — better than protein from many grains, nuts and legumes (19Trusted Source). SUMMARY About 25% of the calories in hemp seeds come from protein. What’s more, they contain all the essential amino acids, making them a complete protein source.

9. 5. Hemp Seeds May Reduce Symptoms of PMS and Menopause Up to 80% of women of reproductive age may suffer from physical or emotional symptoms caused by premenstrual syndrome (PMS) (20Trusted Source). These symptoms are very likely caused by sensitivity to the hormone prolactin (21Trusted Source). Gamma-linolenic acid (GLA), found in hemp seeds, produces prostaglandin E1, which reduces the effects of prolactin (22Trusted Source, 23Trusted Source, 24Trusted Source). In a study in women with PMS, taking 1 gram of essential fatty acids — including 210 mg of GLA — per day resulted in a significant decrease in symptoms (22Trusted Source). Other studies have shown that primrose oil, which is rich in GLA as well, may be highly effective in reducing symptoms for women who have failed other PMS therapies. It decreased breast pain and tenderness, depression, irritability and fluid retention associated with PMS (25Trusted Source). Because hemp seeds are high in GLA, several studies have indicated that they may help reduce symptoms of menopause, too. The exact process is unknown, but the GLA in hemp seeds may regulate the hormone imbalances and inflammation associated with menopause (26Trusted Source, 27Trusted Source, 28Trusted Source). SUMMARY Hemp seeds may reduce symptoms associated with PMS and menopause, thanks to its high levels of gamma-linolenic acid (GLA).

10. 6. Whole Hemp Seeds May Aid Digestion Fiber is an essential part of your diet and linked to better digestive health (29Trusted Source). Whole hemp seeds are a good source of both soluble and insoluble fiber, containing 20% and 80%, respectively (1). Soluble fiber forms a gel-like substance in your gut. It’s a valuable source of nutrients for beneficial digestive bacteria and may also reduce spikes in blood sugar and regulate cholesterol levels (29Trusted Source, 30Trusted Source). Insoluble fiber adds bulk to your stool and may help food and waste pass through your gut. It has also been linked to a reduced risk of diabetes (31Trusted Source, 32Trusted Source). However, de-hulled or shelled hemp seeds — also known as hemp hearts — contain very little fiber because the fiber-rich shell has been removed. SUMMARY Whole hemp seeds contain high amounts of fiber — both soluble and insoluble — which benefits digestive health. However, de-hulled or shelled hemp seeds contain very little fiber.

11. Nutritional analysis of hemp nut (hulled hemp seeds) Calories /100 g 567 Protein 30.6 Carbohydrate 10.9 Dietary fiber 6 Fat 47.2 Saturated fat 5.2 Palmitic 16:0 3.4 Stearic 18:0 1.5

12. Monounsaturated fat 5.8 Oleic 18:1 ( Omega-9 ) 5.8 Polyunsaturated fat 36.2 Linoleic 18:2 ( Omega-6 ) 27.6 Linolenic 18:3 ( Omega-3 ) 8.7 Linolenic 18:3 ( Omega-6 ) 0.8 Cholesterol 0 mg Moisture 5 Ash 6.6

13. Vitamin A (B-Carotene) 4 IU Thiamine (Vit B1) 1 mg Riboflavin (Vit B2) 1 mg Vitamin B6 0 mg Niacin (Vit B3) 0 mg Vitamin C 1.0 mg Vitamin D 0 IU Vitamin E 9 IU Sodium 9 mg Calcium 74 mg Iron 4.7 mg

14. Alanine 1.22% Arginine 3.35% Aspartic acid 2.97% Cysteine 0.39% Glutamic acid 5.31% Glycine 1.21% Histidine* 0.90% Isoleucine* 1.14% Leucine* 1.88% Lysine* 0.91% Methionine* 0.57% Phenylalanine* 1.14% Proline 1.43% Serine 1.60% Threonine* 1.03% Tryptophan* 0.39% Tyrosine 1.04% Valine* 1.42% Meth + cys 0.96% Phen + tyr 2.19%     Protein Digestibility: 0.93 PDCAAS: 0.46 PER: 1.87 Amino Acid Assay of shelled hempseed *=Essential Amino Acid

15. Constituents of hemp Cannabis sativa L. flower essential oil Compound  % of total Myrcene 29.4–65.8 α- Pinene 2.3–31.0 β- Pinene 0.9–7.8 delta -3-Carene trace–3.5 Limonene 0.2–6.9

16. β- phellandrene 0.2–0.6 cis -Ocimene trace–0.3 trans -Ocimene 0.3–10.2 α- Terpinolene trace–23.8 α- Bergamotene trace–0.8 trans -Caryophyllene 3.8–37.5

17. α- Humulene 0.7–7.4 β- Farnesene trace–1.4 β- Selinene trace–0.5 Selina-3,7(11)-diene trace–0.7 Caryophyllene oxide trace–11.3 Total monoterpenes 47.9–92.1 Total sesquiterpenes 4.0–47.5 http://www.internationalhempassociation.org/jiha/jiha4208.html

18. Overdosis Ganja ? LD-50 ganja adalah 1:40.000. LD-50 nikotin adalah 1:50 LD-50 garam dapur adalah 1:3.000 LD-50 aspirin adalah 1:20 LD-50 valium adalah 1:10 LD-50 vitamin C adalah 1:11.900 Francis Young, “Opinion and Recommended Ruling, Findings of Fact, Conclusions of Law and Decision of Administrative Law Judge”, Drug Enforcement Administration (DEA) 6 September 1988 At present it is estimated that marijuana's LD-50 is around 1:20,000 or 1:40,000. In Layman terms this means that in order to induce death a marijuana smoker would have to consume 20,000 to 40,000 times as much marijuana as is contained in one marijuana cigarette. NIDA-supplied marijuana cigarettes weigh approximately .9 grams. A smoker would theoretically have to consume nearly 36,000 grams of marijuana within about fifteen minutes to induce a lethal response.

19. MusriMusman/DP_ALSA/04032020 Gable, R. S. (2006). Acute toxicity of drugs versus regulatory status. In J. M. Fish (Ed.),Drugs and Society: U.S. Public Policy, pp.149-162, Lanham, MD: Rowman & Littlefield Publishers.

20. MusriMusman/DP_ALSA/04032020 Chemicals of Medical Cannabis 1269 known chemical compounds in/on Cannabis Cannabinoids (144 known in Cannabis) THC, CBD, CBN, CBG, CBC, THCV, etc. THCA, CBDA, CBGA, CBCA, etc. Diverse array of therapeutic effects Terpenes & Terpenoids (150 known in Cannabis) Limonene, Linolool, Pinene, Myrcene, b-Carophyllene Smell attributes and diverse therapeutic effects Flavonoids (50 known in Cannabis) Apigenin, Cannflavin-A, Kaempferol, Vitexin, Orientin Very strong anti-oxidants – diverse therapeutic effects

21. Senyawaan Cannabinoids : ∆ 9 -tetrahydrocannabinol (THC) Tetrahydrocannabivarin (THCV) Cannabidiol (CBD) Cannabinol (CBN) Cannabivarin (CBV) Cannabidivarin (CBDV)

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55. Analisa keuangan ganja kering

56. APBA ACEH untuk 2022 sebesar Rp16,17 Triliun . Jadi , sumbangan dana per tahun dari kegiatan ini ke APBA sebesar : (Rp1,05 T/Rp16,17 T) x 100 = 6,49% Bila ada lahan seluas 16 .000 Ha, maka Pemerintah Aceh akan memperoleh pasokan dana sebesar : Rp.1,05 T x 16.000 Ha = Rp.16.8 T/ tahun

57. Analisa keuangan minyak ganja 1 Ha = 100 kg ganja kering 1 Tahun = 3 kali panen Besar dana yang diperoleh bila diolah menjadi minyak adalah 3 x 100 kg ganja kering x 1000 g/1 kg x 4 g minyak /30 g ganja kering x US$60/g minyak x Rp.14.500.-/US$ = Rp.34.800.000.000.-

58. Bila ada lahan 1000 Ha, besar dana yang diperoleh dalam 1 tahun adalah 1000 Ha x Rp.34.800.000.000.- = Rp.34.800.000.000.000 .- APBA ACEH tahun 2022 sebesar Rp.16,17 Triliun . Jadi, sumbangan dana per tahun dari kegiatan ini ke APBA sebesar : (Rp.34,8 T/Rp.16,17 T) x 100 = 215,21%

59. Biji dihasilkan 353,80 kg/Ha. Minyak biji ganja yang dapat dimakan ( mengandung 8 protein esensial dan 3 asam lemak esensial ) dihasilkan sebesar 25 – 35%. Dana yang diperoleh dari minyak komponen esensial sebesar 30% x 353,80 kg = 106,14 kg x 300 mL/kg = 31.842 mL = 32L x Rp373.330/L = Rp11.946.560.- Tepung biji pasca pengambilan komponen esensial ( mengandung protein, PUFA, dan mineral) memiliki komposisi 55% asam linoleat ( ω-6) dan 25% asam linolenat ( ω -3). Dana yang diperoleh dari tepung biji sebesar 60% x 353,80 kg = 212,28 kg x Rp.215.575/0,45 kg = Rp.101.693.913. Dana yang dihasilkan dari serat sebesar 30% 2.165 kg per ha x Rp.228.825 per kg = Rp. 495.406.125.- Dana yang dihasilkan dari CBD bunga sebesar 264,90 kg per ha x Rp.20.852.813.- per kg = Rp.5.523.911.488,20.- Dana yang dihasilkan dari Biomassa CBD sebesar 383,29 kg per ha x Rp.3.811.031.-/0,454 kg = Rp.3.217.467.119.-

60. Dari kelima komoditas dimaksud , dana diperoleh dalam 1000 Ha per tahun (3x) untuk : Minyak essensial sebesar Rp.11.946.560.-/Ha x 1000 Ha x 3 = Rp.35.839.680.000.- Tepung biji sebesar Rp.101.693.913.-/Ha x 1000 Ha x 3 = Rp.305.081.739.000.- Serat sebesar Rp.495.406.125.-/Ha x 1000 Ha x 3 = Rp.1.486.218.375.000.- CBD dari bunga sebesar Rp.5.523.911.488,20.- x 1000 Ha x 3 = Rp.16.571.734.464.600.- Biomassa dari produksi CBD sebesar Rp.3.217.467.119.-/Ha x 1000 Ha x 3 = Rp.9.652.401.357.000.- sebesar Rp.28.051.275.615.000.-

61. APBA ACEH tahun 2022 sebesar Rp.16,17 Triliun . Besar dana yang diperoleh dalam 1 tahun adalah Rp. 28.051.275.615.000 .- Jadi, sumbangan dana per tahun dari kegiatan ini ke APBA sebesar : (Rp.28,05 T/Rp.16,17 T) x 100 = 173,47%

62. TERIMA KASIH