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1. Cahn-Ingold-Prelog (CIP) Rules: R and S Configuration This presentation will introduce the Cahn-Ingold-Prelog (CIP) rules for assigning R and S configuration to chiral centers in molecules. B

2. Step-by-Step Guide to Assigning Priority Step 1: Identify Chiral Center Locate the carbon atom with four different substituents. Step 2: Assign Priority Determine the priority of the four substituents based on atomic number. Step 3: Orient Lowest Priority Group Position the group with the lowest priority away from the viewer. Step 4: Determine R/S Configuration Observe the direction of the remaining three groups. Clockwise = R, counterclockwise = S.

3. Determining R/S Configuration with Examples 1 First, identify the chiral center. 2 Then, assign priority to the four substituents based on their atomic number. 3 Orient the lowest priority group away from the viewer and determine the direction of the remaining three groups.

4. Common Pitfalls and Practice Problems Double bonds can be tricky to prioritize. Always ensure the lowest priority group is positioned away from the viewer. Practice makes perfect - work through multiple examples.

5. Example: 2-Butanol 1. Identify Chiral Center The second carbon atom in 2-butanol is the chiral center, bonded to four different groups: H, OH, CH3, and CH2CH3. 2. Assign Priority Based on atomic number, the hydroxyl group (-OH) has the highest priority (1), ethyl group (-CH2CH3) is second (2), methyl group (-CH3) is third (3), and hydrogen (-H) is last (4). 3. Orient Lowest Priority Group Visualize the molecule with the hydrogen atom (priority 4) pointing away from you, into the plane of the page. 4. Determine R/S Configuration Looking at the remaining three substituents (OH, CH2CH3, and CH3), if they are arranged in a clockwise direction from highest to lowest priority, the configuration is R.

6. Lab Safety: Flammable Materials Flammable materials pose a significant risk in lab settings, requiring strict safety protocols for handling, storage, and disposal. This presentation outlines key precautions and best practices. RB

7. Handling Flammables: Precautions & Best Practices Safe Storage Flammables must be stored in designated cabinets or containers with proper ventilation. Avoid storing near heat sources, open flames, or electrical equipment. Always ensure containers are tightly sealed and labeled clearly. Proper Handling Always handle flammable materials with care, minimizing spills and leaks. Use appropriate equipment, such as pipettes and safety glasses. Work in well-ventilated areas, and never use open flames or electrical devices near flammables.

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