Presentation on LDA (LITHIUM DI ISOPROPYL AMINE

Detailed information of lithium diisopropyl in which organometallic compound information has given and Preparation and properties of lda has been discuss

1. LITHIUM DI ISOPROPYL AMINE (LDA)

2. CONTENTS

3. Organo metallic compounds Which posses metal carbon bond. Contain at least one metal carbon bond. They have differences in electronegativites. Examples-Li(CH 3 ) 4 , Al(CH 3 ) 6 etc. Properties The bond between metal can carbon atom is highly covalent. The compound consist highly positive atoms. These compound are used as reducing agents

4. Lithium Di Isopropyl Amide(LDA) LDA is prominent reagent used in organic reagents. Molecular formula LiN(CH(CH3) 2 ) 2 Used as strong base due to good solubility in non organic solvent. It is a colorless solid. It is prepared from isopropyl and butyl lithium in presence THF . LDA is poor nucleophile.

5. Preparation Di isopropylamine Lithium diisrpylamine (LDA)

6. Properties LDA is strong Nucleophilic strong base . It is very poor nucleophile . Does not give nucleophile substitution even with alkyl halides tosylates . Does not give nucleophile addition with ketone and nitriles . Abstract hydrogen from active carbon CH 2 C CH 2 + LDA CH 2 CH Li

7. Formation of enolates with LDA

8. Applications LDA is used for the generation of carbanion or enolate anions from carbonyl group-containing compounds. It can also be used as a base in: The direct alkylation and acylation of ketones. It abstract hydrogen from active carbon. Used in formation of enolates and aldol condensation

9. Refrences https://courses.lumenlearning.com/suny-potsdam-organicchemistry/chapter/9-7-enolate-alkylation/ https://www.masterorganicchemistry.com/2011/08/05/reagent-friday-lithium-di-isopropyl-amide-lda/ https://en.wikipedia.org/wiki/Lithium_diisopropylamide https://www.scientificlabs.co.uk/product/organic-acids-and-bases https://prepchem.com/synthesis-of-lithium-diisopropylamide/ https://cdn.masterorganicchemistry.com/wp-content/uploads/2019/12/3-alkylation-of-enolates-using-lda-through-formation-of-the-least-substituted-enolate.gif