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1. An-Najah National University
Chemical Engineering Department
Microemulsion In Drug Delivery Systems
Prepared by:
Hana’aTareq
Ibtihaj Awwad
Hadeel Suliman
Alaa Badran
Superior : Dr. Husni Odeh
Submitted to Chemical Engineering Department
Second Semester, 2010-2011
6/2/2024 1
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

2. •Objectives.
•Microemulsion .
•Advantage and disadvantage of microemulsion.
•Solubility and Bioavailability.
•Earlier study of microemulsion in the drug.
•Materials.
•Experimental work.
•Results and discussion.
•Conclusion.
•Recommendation.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

3. This project aim to design and develop of microemulsion
drug delivery system .
Improved the solubility and bioavailability of curcumin
drug by using microemulsion.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

4. Microemulsion are liquid dispersions of water and oil that are
made homogenous, transparent and thermodynamically stable
by the addition of relatively large amounts of surfactant and co-
surfactant and having diameter of the droplets in the range of
100 –1000 A (10 –100 nm).
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

5. Microemulsions are thermodynamically stable system
and the stability allows self-emulsification of the system
whose properties are not dependent on the process
followed.
Microemulsion have low viscosity compared to other
emulsions.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

6. Microemulsion can improve the efficacy of a drug,
allowing the total dose to be reduced and thus minimizing
side effects.
microemulsion are easy to prepare and require no
significant energy contribution during preparation.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

7. Use of a large concentration of surfactant and co-
surfactant necessary for stabilizing the nano-droplets.
The surfactant must be nontoxic for using pharmaceutical
applications .
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

8. Microemulsion stability is influenced by environmental
parameters such as temperature and pH.These parameters
change upon microemulsion delivery to patients.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery
system

9. Bioavailability of a drug is largely determined by the
properties of the dosage form.
The therapeutic index : ratio of the minimum toxic
concentration to the median effective concentration.
Low bioavailability is most common with oral
dosage forms of poorly water-soluble, slowly absorbed
drugs.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

10. Solubility : the amount of a substance that
dissolves in a given volume of solvent at a specified
temperature.
Poor aqueous solubility .
High lipophilicity.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

11. Cyclovir
Labrasol(surfactant)
32%
PlurolOleique
((co-surfactant
8%
Labrafac(oil)
10%
Water
50%
Bioavailability increases (12.78 times)
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

12. Valsartan
Tween80
(surfactant)
45%
PEG 400
((co-surfactant
45%
CapmulMCM
(oil)
10%
The release increased more than 90% when compared with
marketed formulation
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

13. Glyburide(GLY)
Tween-20(sur).
TranscutolP (co-sur)
Capryol90 (oil) Water
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

14. 6/2/2024 14
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

15. Microemulsion
systems
System no.1
Tween20, Span 80
(Sur. Mix)
Jojoba oil(95%),
clove oil (5%)
System no. 2
Tween20,
span80 (Sur. Mix.)
Clove oil
≃100%
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

16. Curcumin
Preparation
Microemulsion
Preparation
Solubility Test
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

17. Addition af
surfactant/
co-
surfactant
Addition of
oils
Addition of
water.
Shaking.
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Chemical Engineering Department-Graduation
Project-Microemulsion Drug Delivery system 17

18. 6/2/2024
Chemical Engineering Department-Graduation
Project-Microemulsion Drug Delivery system 18
Amount of
oil
0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8
Amountof
Sur. Mix
1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2
Table(1): Initial concentration values of oil and Sur. Mix. For the two systems

19. Drug solubility experiments
Drug solubility experiments were carried out based on the
previous microemulsion experiments. It was experienced that
for:
First system jojoba oil and clove oil:
surfactant/co-surfactant, oil, water(3.01%,27.07%,69.9%).
surfactant/co-surfactant, oil, water (6%,24.28%,69.72%).
surfactant/co-surfactant, oil, water(9.02%,21.11%,69.87%) .
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

20. Second system clove oil :
surfactant/cosurfactant,oil, water (3%, 27.14%, 69,86%).
surfactant/cosurfactant,oil, water(6.02%,24.06%,69.92%).
surfactant/cosurfactant,oil, water (9.01%,21.15%,69.84%) .
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

21. Due to the addition of water the shape and color of
emulsions were changed.(3, 2, 1 phases)
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

22. 0
10
20
30
40
50
60
70
80
90
100
0 10 20 30 40 50 60 70 80 90 100
Surfactant %
Oil %
ME
Figure(1): Triangle Phase Diagram of oil , Sur. Mix. And Water6/2/2024 22

23. The highest solubility of curcumin 5mg/ml is found at
(20%,10%,70%): (S mix./oil/water) microemulsion system.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

24. Microemulsion is excellent candidate as potential drug delivery
system.
The microemulsion system occurred at (20% S
mix ,10% oil
,70% water).
The highest drug solubility of curcumine 5mg/ml is found at
(20%/10%/70%) : (Smix/oil/water) microemulsion system.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

25. 1. Microemulsion method is one of the best method of drug
delivery to increase bioavailability of drug.
2. Deep study must be done for each material used in preparation
of ME.
3. Careful dealing with components while adding them to the
system.
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Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

26. 4. Use pre-calibrated devices for measuring amounts of
components.
5. Use suitable shaking device that offer gentle mixing
for several tubes that save time and effort.
6. Use Pure Water in Preparation of ME
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27. 6/2/2024 27
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery
system