Prostaglandin biosynthesis & therapeutic uses of prostaglandin analouges

1. Prostaglandin bIOSYNTHESIS & Therapeutic uses of prostaglandin analogues Dr . Jannatul Ferdoush Assistant Professor Department Of Pharmacology

2. Prostaglandin Biosynthesis

3. Prostaglandin analogues Prostaglandin E 1 : Misoprostol (oral , Intravaginal ) Gemeprostol Alprostadil (IV , Intraurethral , Intracavernosal route) Prostagladin I 2: Epoprostenol (IV) Prostaglandin F 2 α : Latanoprost ( Opthalmic ) Carboprost (IM) Prostaglandin E 2 : Dinoprostone ( I ntravaginal )

4. Misoprostol (Prostaglandin E 1) Clinical use: NSAID induced pectic ulcer Therapeutic abortion Induction of labour NSAID induce gastric ulcer occur mainly due to decrease in PG synthesis. It cause ripening & softening & dilatation of cervix. It binds to myometrial cells to cause strong contraction , leading to expulsion of product of conception.

5. ALProstadil (Prostaglandin E 1) Use : T o maintain patency ductus arteriosus The ductus arteriosus in neonate is highly sensitive to PG E1. M aintence of patent ductus arteriosus is important for neonate with congenital heart disease.

6. epoprostenol ( Prostagladin I 2) Use : Pulmonary hypertension. It work by relaxing the blood vessels ↓ increasing the supply of blood to the lung ↓ reducing work load of the heart.

7. latanoprost ( Prostaglandin F 2 α ) Use:open angle glucoma it reduce intraocular pressure by increasing the removal aqueous humor from the eye.

8. CARBOPROST: Prostaglandin F 2 CARBOPROST: Prostaglandin F2 α Use: PPH Its use for it oxytocic action. .

9. DINOPROSTONE (Prostaglandin E 2) Use : Termination of pregnancy I nduction of labour PPH A ct directly on myometrium to induce contraction Relaxation of cervix.

10. cont ’ d Adverse effect: Abdominal cramp ,nausea , vomiting D iarrhoea B ronchospasm priapism Contraindication: pregnancy

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