Renin angiotensin-aldosterone system

this is a summary of RENIN-ANGIOTENSIN-ALDOSTERONE systeme easy to understand!

1. RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM Prepared by NSANZIMANA VEDASTE UR-CMHS, BLS Department

2. The renin-angiotensin-aldosterone system (RAAS) stabilizes blood pressure and volume via the kidneys, liver, and adrenal cortex.

3. TERMS Angiotensin Any of several polypeptides that narrow blood vessels and thus regulate arterial pressure Renin A circulating enzyme released by mammalian kidneys that converts angiotensinogen to angiotensin -I that plays a role in maintaining blood pressure Aquaporin Any of a class of proteins that form pores in the membrane of biological cells

4. Key Points Renin , a hormone produced the juxtaglomerular apparatus in the kidneys, converts angiotensinogen (which is made in the liver) to angiotensin I. Angiotensin I is then converted to angiotensin II by the angiotensin converting enzyme (ACE), increasing blood pressure by causing vasoconstriction of the blood vessels.

5. Angiotensin II causes the release of aldosterone which is produced by the adrenal cortex; it functions to maintain both sodium and water levels (osmotic balance) in the blood. Angiotensin II also causes the release of antidiuretic hormone (ADH) which functions to conserve water in the body when volume is low; it does this by inserting aquaporins in the collecting duct of the nephron to promote water reabsorption . .

6. The atrial natriuretic peptide (ANP) is another hormone that is produced to function as a vasodilator and lower blood pressure by preventing sodium reabsorption

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