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1. ROM regimen in leprosy Roll: 71,72,73,74

2. ROM regimen in Leprosy Rifampicin — 600mg Ofloxacin — 400mg Minocycline — 100mg Single dose for single lesion PB leprosy Given 3 times weekly for 6 weeks for PB leprosy and 12 weeks for MB leprosy showed significant clinical improvement in our leprosy patients. Thus, ROM regimen could be a more effective, safer, faster alternative treatment than MDT regimen recommended by the WHO for leprosy.

3. Indication 1. Single skin lesion paucibacillary (SSLPB) leprosy (the only standard indication). •Recommended by WHO (1998) as an alternative to 6-month PB-MDT. 2.In some NLEP (India) field trials/programs, used for SSLPB cases to improve compliance. 3.In patients where MDT compliance is doubtful (remote areas, difficulty in follow-up). 4.When dapsone cannot be given (e.g., dapsone hypersensitivity) and the patient has a single skin lesion PB case.

4. Limitations • Not effective in MB / multiple lesions → higher relapse risk • Cannot be given to children <14 yrs, pregnant or lactating women • MDT is still the standard of care; ROM is now rarely used

5. Advantages •Single-dose → excellent compliance •Useful in field programs / NLEP (National Leprosy Eradication Programme,India) •As effective as PB-MDT for single lesion cases

6. Thank you