Self- microemulsifying drug delivery systems (SMEDDS).pptx

Self- microemulsifying drug delivery systems (SMEDDs)

1. Self- microemulsifying drug delivery systems (SMEDDS) Name: Ishika Choudhary M . Pharma

2. Introduction to SMEDDS Definition : Self- Microemulsifying Drug Delivery Systems (SMEDDS) are isotropic mixtures of oil, surfactant, co-surfactant, and drug that spontaneously form microemulsions when exposed to aqueous media. Key Features : Self-emulsifying : Form fine droplets without external energy. Microemulsions : Transparent, stable, and nanosized droplets (10-100 nm). Improved Drug Solubility : Enhances bioavailability of poorly water-soluble drugs.

3. Components of SMEDDS Oil Phase : Solubilizes lipophilic drugs. Examples: Medium-chain triglycerides (MCT), olive oil. Surfactants : Lower interfacial tension, facilitating emulsification. Examples: Tween 80, Cremophor EL. Co-Surfactants : Enhance stability and reduce interfacial tension. Examples: Ethanol, isopropyl myristate. Active Pharmaceutical Ingredient (API) : Lipophilic drugs are commonly used.

4. Mechanism of SMEDDS Formation Spontaneous Formation : When SMEDDS contacts aqueous medium (e.g., stomach fluids), it forms a microemulsion. Emulsification Process : Surfactants create droplets of oil phase. Oil droplets encapsulate the drug, increasing surface area. Facilitates efficient absorption across gastrointestinal mucosa.

5. Preparation Methods of SMEDDS Simple Mixing Method : Mix oil, surfactant, co-surfactant, and drug at ambient temperature. Advantages : Simple and cost-effective. Solvent Evaporation : Dissolve components in an organic solvent, evaporate to form SMEDDS. Advantages : High drug loading. High-Shear Mixing : Use high shear mixers for improved dispersion and uniformity. Hot Homogenization : Heat the system to improve mixing and emulsification.

6. Advantages of SMEDDS Enhanced Solubility : Improves the solubility of poorly water-soluble drugs. Increased Bioavailability : Enhances drug absorption and bioavailability. Improved Absorption : Faster and more efficient absorption in the gastrointestinal tract. Thermodynamic Stability : No need for external energy input, easy to prepare and store. Easy Manufacture : Simple preparation processes. Reduced Food-Effect : Consistent drug absorption with or without food. Versatility : Can deliver a wide range of lipophilic drugs.

7. Disadvantages of SMEDDS Size Limitation : Droplet size variation can impact drug release profiles. Need for Co-Surfactants : Adds complexity and cost. Drug Compatibility : Some drugs may not be compatible with the formulation. Gastrointestinal Irritation : High surfactant concentrations can irritate the GI tract.

8. Applications of SMEDDS Oral Drug Delivery : Improves absorption of poorly soluble drugs. Targeted Delivery Systems : Delivers drugs to specific sites in the body. Cancer Therapy : Enhances the delivery of anticancer drugs. Vitamins & Nutraceuticals : Improves absorption of fat-soluble vitamins. Transdermal Drug Delivery : SMEDDS for topical drug delivery.

9. Evaluation of SMEDDS Appearance : Clarity and visual appearance of microemulsions. Droplet Size : Size distribution of droplets to ensure uniformity. Zeta Potential : Measures system stability. Drug Release Studies : In-vitro drug release to assess performance. Stability Studies : Long-term stability under different storage conditions.

10. Future Trends and Research Personalized Medicine : SMEDDS tailored to individual patient needs. Nano-SMEDDS : Nano-sized formulations for targeted therapies. Combination Therapies : Delivery of multiple drugs for multi-target treatments. Biodegradable Surfactants : Eco-friendly surfactants for sustainable formulations.

11. Conclusion SMEDDS offer a promising solution for enhancing solubility, bioavailability, and drug absorption. Simple preparation, thermodynamic stability, and versatility make them a valuable option in pharmaceutical formulations. Ongoing research is optimizing SMEDDS for advanced drug delivery, including personalized and targeted therapies.

12. Thank You