SEnolytics ppresentation.pptx on the drug discovery

science

1. Outline Background Results conclusion

2. What comes in your mind ? What’s your contemplation on seeing this cartoon image? What’s the Difference between Senescence & Aging?

3. What are senescence cells? How do they come into existence ? SASP Can help in tissue repair in the short term. However In Long term causes chronic inflammation on their accumulation Causes Cancer prevention

4. Cont. Chemokines cytokines Proteases Growth factors Prostaglandins Senescence Associated secretory Phenotype (SASP)

5. Senomorphics Senolytics What are the effects of SASP? What are the remedies for eradication of the senescent Cells?

6. Results 1.Transplanting small numbers of senescent cells induces physical dysfunction in younger mice

7. 85% senescency

8. 2. Aging and high fat diet worsens the effects of senescent cell transplantation

9. 3. Senescent cells reduce resilience to metabolic stress in mice HFD -High Fat Diet- NCD - Normal Chart Diet

10. 4.Dasatinib plus quercetin reduces senescent cell burden and decreases proinflammatory cytokine secretion in human adipose tissue CM - Conditioned Media

11. Why use a combination of these two drugs?

12. 5. Eliminating senescent cells both prevents and alleviates physical dysfunction induced by senescent cell transplantation

13. 6. Clearance of senescent cells alleviates physical dysfunction and increases late-life survival without extending morbidity in aged mice

14. CONCLUSION senescent cells can amplify inflammation in adipose tissue, and reducing these cells may decrease inflammation and senescence spread, delaying the onset of age-related diseases as a group rather than any single condition. Intermittent administration of D+Q was shown to increase late-life survival without significant side effects associated with continuous dosing, possibly due to the elimination of senescent cells. targeting senescent cells could enhance both health- and lifespan

15. Thank You