CLINICAL INDICATIONS Indications for examination of sensory function are based on the history and systems review this includes “information provided by the patient/client, family, significant other, or caregiver; symptoms described by the patient/client; signs observed and documented during the systems review; and information derived from other sources and records.” these data may indicate the existence of pathology (or risk of pathology) resulting in sensory changes that may impose impairments, activity limitations, participation restrictions, or disability (see Box 3.1). Sensory dysfunction may be associated with any pathology or injury affecting either the peripheral nervous system (PNS) or CNS, or with a combined involvement of both systems. Deficits may occur at any point within the system including the sensory receptors, peripheral nerves, spinal nerves, spinal cord nuclei and tracts, brainstem, thalamus, and sensory cortex . Examples of conditions that generally demonstrate some level of sensory impairment include pathology, disease, or injury to the peripheral nerves such as trauma (e.g., fracture) that can sever, crush, or damage a nerve; metabolic disturbances (diabetes, hypothyroidism, alcoholism); infections (Lyme disease, leprosy, human immunodeficiency virus [HIV]); impingement or compression (arthritis, carpal tunnel syndrome); burns; toxins (lead, mercury, chemotherapy); and nutritional deficits (vitamin B12). Sensory impairments are also associated with injury to nerve roots or spinal cord, cerebral vascular accident (CVA), transient ischemic attack (TIA), tumors, multiple sclerosis (MS), and brain injury or disease. These examples, which are not all-inclusive, indicate the wide spectrum of injuries, disease, and pathologies that may present with some element of sensory deficit.