Solubility 2: Ideal Solubility Parameters, Regular Solutions Theory, Unit Solubility Parameters, Application of Solubility Parameters, Methods of Determining Ideal Solubility Parameters

Ideal Solubility Parameters, Regular Solutions Theory, Unit Solubility Parameters, Application of Solubility Parameters,
Methods of Determining Ideal Solubility Parameters

1. SOLUBILITY -2
Presented By:
Mr. S.M. Ambore
Asst. Professor,
DK Patil Institute of Pharmacy, Loha. Nanded

2. LEARNINGOUTCOMES….
Ideal Solubility Parameters
Regular Solutions Theory
Unit Solubility Parameters
Application of Solubility
Parameters
Methods of Determining Ideal
Solubility Parameters
2

3. 3
1.ToestimatesolubilitysomeIdealSolubilityParameters
arerequired.
2.TheseareexplainedwithREGULAR SOLUTION
THEORY.
3.RegularSolutionTheorymainlydealswithnon-polar
moleculeslikepolymers.
4.Itsuggestanumericalestimationaboutextentof
solubility.
IDEALSOLUBILITYPARAMETERS

4. REGULAR SOLUTION THEORY
4
Where,
d1 = solubility parameter
dU = Molar energy
V = Molar volume of solvent
dU / V = Cohesive energy of solvent
dH = Heat of vaporization of solvent
R = Gas constant
T = Temperature
V = Molar volume of solvent

5. 5
d1 –d2 = Gives numerical value for solubility

6. 6
Unit of Solubility
Parameters
Conventional SI

7. REFLECTIONSPOT
Can you guess what will be the applications of solubility
parameters?
7

8. 8
Selection of Solvent
Preparation of Polarity Scale
Co solvency Power
determination
Chemical Kinetic
determination
Determination of mechanism in
drug action
Structural activity
relationship (SAR)
Drug transport through model
membrane
APPLICATION OF SOLUBILITY PARAMETERS

9. 9
Regular Solution
Theory
Advantage:
To predict excess
free energy of
solution
Disadvantage:
Unable to predict
Heat of solution,
Volume after mixing

10. 10
METHODSOFDETERMININGIDEAL
SOLUBILITYPARAMETERS
Small’s Method
Hoy’s Method
Van Krevelen’sMethod
Konstam& Feairheller
Method
RheineckMethod
Feder’sMethod
Wolf’s Method

11. 11