Structure of Hemoglobin

Structure of Hemoglobin

1. Structure Of Hemoglobin V.S.RASHMI PRIYEM ULTRA’S BEST DENTAL SCIENCE COLLEGE

2. HEMOGLOBIN CONJUGATED PROTEIN CONTAINING HEME AND GLOBIN TETRAMERIC ALLOSTERIC PROTEIN

3. HEME NON PROTEIN PART PROSTHETIC PART

4. GLOBIN APOPROTEIN PART

5. RBCs RED BLOOD PIGMENT IN ERYTHROCYTES

6. NORMAL CONCENTRATION MALES 14-16 g/ dL FEMALES 13-15 g/ dL

7. BIOCHEMICAL FUNCTION ASSOCIATED WITH RESPIRATION DELIVERY OF O 2 FROM LUNG TO TISSUES TRANSPORT OF CO 2 AND PROTONS FROM TISSUES AND LUNGS

8. SHAPE HEMOGLOBIN IS GLOBULAR IN SHAPE

9. HbA MADE UP OF 2 α CHAINS 2 β CHAINS NORMAL BLOOD CONTAINS 97% HbA

10. HbA2 MADE UP OF 2 α CHAINS 2 δ CHAINS NORMAL BLOOD CONTAINS 2% HbA2

11. HbF MADE UP OF 2 α CHAINS 2 γ CHAINS NORMAL BLOOD CONTAINS 1% HbF

12. GENES RESPONSIBLE ALPHA CHAIN GENE IS PRESENT ON CHROMOSOME 16 BETA, GAMMA AND DELTA CHAIN GENES ARE PRESENT ON CHROMOSOME 11

13. AMINO ACIDS EACH ALPHA CHAIN HAS 141 AMINO ACIDS EACH BETA, GAMMA AND DELTA CHAINS HAVE 146 AMINO ACIDS ON A TOTAL HEMOGLOBIN CONTAINS 574 AMINO ACIDS

14. STRUCTURE OF HEME CONTAINS PORPHYRIN RING CONSISTS OF 4 PYRROLE RINGS LINKED BY METHYLENE BRIDGES WITH IRON(FERROUS STATE) AT ITS CENTER

15. STRUCTURE OF GLOBIN CONSISTS OF 4 POLYPEPTIDE CHAINS CONTAINS 574 AA RESIDUES

16. BUFFERING ACTION CONTAINS 36 HISTIDINE RESIDUES IMP. IN BUFFERING ACTION

17. DISTAL HISTIDINE 58 TH AA IS HISTIDINE KNOWN AS DISTAL HISTIDINE AWAY FROM IRON ATOM

18. PROXIMAL HISTIDINE 87 TH AA IS HISTIDINE KNOWN AS PROXIMAL HISTIDINE NEAR TO IRON ATOM

19. BONDING 4 SUBUNITS HELD TOGETHER BY NON-COVALENT INTERACTIONS HYDROPHOBIC, IONIC AND HYDROGEN BONDING

20. HYDROPHOBIC CLEFT THERE ARE 4 HEME RESIDUES PER Hb , ONE FOR EACH SUBUNIT IN Hb HEME IS LOCATED IN A HYDROPHOBIC CLEFT OF GLOBIN CHAIN