Sulphonic acid and Phenol

This is a presentation on sulphonic acid and phenol (aromatic compounds)

1. Bangabandhu Sheikh M ujibur Rahman Science and Technology University A presentation on Sulphonic acid Presented by Md. Shimul Bhuia St. ID: 16PHR003 Department of Pharmacy

2. Welcome

3. Sulphonic acid They may be regarded derivatives of sulfuric acid in which on –OH group has been replaced by an aryl group, Ar H 2 SO 4 ArHSO 3 Sulfuric acid Arenosulfonic Acid Example:

4. Preparation Direct Sulfonation :

5. Chemical Properties 1. The order of acidity for sulphonic acid , Sulphonic acids are more acidic than carboxylic acids

6. Reaction Reaction with bases to form salts : Reaction with PCl 5 :

7. Pharmaceutical importance In pharmaceutical materials science To develop the dosage forms In natral products and anti-cancer drugs Implications of the discovery of human genome for drug therapeutic strategies and advances in tissue engineering Physical properties Aromatic sulfonic acid are white crystalline solids They do not have sharp melting points They are soluble in water

8. Phenol Phenol are compounds containing an –OH group attached directly to an aromatic ring Preparation: 1. From diazonium salts

9. Chemical properties The reactions of phenols are the reactions of the –OH group and the benzene ring Formation of salts: Phenol is more acidic than aliphatic alcohols because conjugate base is stabilized by resonance.

10. Reaction of Phenol Halogenation. Nitration. Sulfonation .

11. Pharmaceutical uses As a antiseptic In aspirin As an topical anaesthetic and ear drops, sclerosing agent In the treatment of ingrown nails in the “nail matrix phenolization method” As a neurolytic agent applied in order to relicve spams and chronic pain It is used in dermatology for chemical face peeling.

12. Thank you