Suspension

Suspension dosage form
Kiran Rodge

1. SUSPENSION
Kiran C Rodge
Shivlingeshwar college of Pharmacy,
Almala, Tq-Ausa,Dist-Latur,Maharashtra

2. 2
“A Pharmaceutical suspension is a biphasic liquid
dosage form in which internal phase is dispersed
uniformly as finely divided insoluble particles throughout
the external phase, The range of dispersed solid particles in
suspension from 0.5 to 5.0 micron. ”

3. 3
Ideal Properties of Suspension
Particle size should be small & uniform.
Re‐ suspension of particles occur easily.
Dispersed particles do not settle rapidly after shaking
Cake formation not occur during its shelf life.
Maintain its stability and elegance during its shelf life
Isotonic & non‐irritating
Particle size less than 5 μm.
Sterility during its storage & use.
Syringeability & injectability

4. 4
Advantages of Suspension
Suspension can improve chemical stability of certain
drug.
Drug in suspension exhibits higher rate of
bioavailability than other dosage forms. Solution >
Suspension > Capsule > Compressed Tablet > Coated
tablet
Duration and onset of action can be controlled
Suspension can mask the unpleasant/bitter
taste of drug.

5. 5
Disadvantages of Suspension
Physical stability, sedimentation and
compaction can causes problems.
It is bulky. Sufficient care must be taken
during handling and transport.
Uniform and accurate dose may not be achieved.

6. Types Of Suspension
6
1.Genral Use
a. Oral
b. Topical
c. Parenteral
2. Proportion of solid Particles
a. Dilute Suspension
b. Concentrated Suspension

7. Types Of Suspension
7
3.Size of solid particles
a. Corse Dispersion (More than 0.2 μm)
b. Colloidal Dispersion (In between 0.1-0.2 μm)
c. Molecular Dispersion ( Less than 1 nm)
4. Electrokinatic nature of solid
a. Flocculated Suspension
b. Deflocculated Suspension

8. 8

9. 9
Formulation
Of
Suspension

10. 1.Particle Size
1.Small Size
a. Low Sedimentation rate
b. Hard cake formation
c. Crystal growth
2.Large Size
a. High Sedimentation rate
b. Syngibility & injectibility
c. Gritty appearance
3.Polydispersed
All problems observed in small & large size

11. 11
2.Suspending Agent
Suspending agents are substances that are used to keep
finely divided insoluble materials suspended in a
liquid media by preventing there agglomeration
(coming together) and by imparting viscosity to the
dispersion media so that the particles settle more slowly.

12. “
12
Types of suspending agents
1. Natural Agents
a. Animal source eg Gelatine
b. Plant source eg. Accacia, Tragacanth
c. mineral sources.eg Bentonite, Kaoline
2. Semi-synthetic Agents
Hydroxyethylcellulose,Sodium
Carboxymethylcellulose, methylcellulose,
Microcrystalline cellulose
3. Synthetic Agents
Carbopol, Polyvinyl Alcohol,
Polyvinyl Pyrolidone iodine complex (PVC)

13. 13
3.Wetting Agent
The class of compounds which increases the solubility of
drug compound in solvent by reducing wetting angle ”
⪢Use of Surfactant
⪢ use of Hydrophilic colloids
⪢Solvents

14. 14
4.Flocculating Agents
Flocculating agents decreases zeta potential of the
suspended charged particle and thus cause
aggregation (floc formation) of the particles.
Ionic surfactant
Polymeric flocculating agents
Electrolytes

15. 15
DLVO Theory

16. 5. Viscosity Modifiers
16
The class of compound which alter the viscosity of
the pharmaceutical product are called viscosity
modifiers.
Polysaccharides Acacia,Tragacantrh,alginates
Water soluble cellulose MC,HEC,Na
CMC,MCC
Hydrated silicates Bentonite,MAS
Carbmers Aerosil

17. 17
6. Antioxidants
7.Preservatives
8.Buffers
10.Density Modifiers
9.Isotonicity Modifiers
11.Coloring agents
13.Flaouring Agents
12.Sweating Agents

18. Evaluation
18

19. Methods of assessing stability
19
1.Macroscopic Examination
2.Globule Size analysis
3.Accelerated Stability tests
a. Storage at adverse temperature
b. Temperature cycling
c. Centrifugation

20. 20
Thanks!
Any questions?
You can find me at:
9579827675
[email protected]