TB Resistance Mutations presentation lecture

TB Resistance Mutations presentation lecture

1. TB Resistance Mutations

2. RPOB Gene 4KMU normal + RIF 5UAL S531L mutation + RIF 5UAJ S531L Mutation 5UAQ H526Y Mutation 5UAG D516V Mutation 5UAH D 516V Mutation + RIF 5UAC wild type + RIF

3. Mutations effects

4. PLIP: Protein-Ligand Interaction Profiler 1- Normal (4KMU) for visualization https://plip-tool.biotec.tu-dresden.de/plip-web/plip/result/a218edae-e352-4925-abcb-05290415fb5a

5. 2- Normal (5UAL) for visualization https://plip-tool.biotec.tu-dresden.de/plip-web/plip/result/729e1a99-b9b6-4cff-80f5-9b21d71fc375

6. Docking Swiss dock NORMAL

7. Docking Swiss dock MUTATED

8. Docking ANACONDA NORMAL

9. Docking ANACONDA MUTANT