Tertiary structure of protein

The tertiary structure will have a single polypeptide chain "backbone" with one or more protein secondary structures, the protein domains.

1. PRESENTED BY :- APUSI CHOWDHURY T ERTIARY S TRUCTURE O F P ROTIEN

2. CONTENTS Introduction Interaction stabilizing tertiary structure How tertiary structure is stabilized???? Tertiary structure is important!! Reference

3. INTRODUCTION

4. Reference :https://en.wikipedia.org/wiki/Protein_tertiary_structure The term protein tertiary structure refers to a protein's geometric shape. The tertiary structure will have a single polypeptide chain "backbone" with one or more protein secondary structures, the protein domains.  Amino acid side chains may interact and bond in a number of ways. The interactions and bonds of side chains within a particular protein determine its tertiary structure.

5. INTERACTIONs STABILIZING TERTIARY STRUCTURE

6. Reference: Lippincott’s illustrated reviews: biochemistry, pg : 21- 22 FOUR TYPES OF INTERACTION Disulfide bond Hydrophobic interaction Hydrogen bonds Ionic interaction

7. How tertiary structure is formed by these interaction???

8. T ERTIARY S TRUCTURE I S I MPORTANT!!!

9. Reference: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/TertiaryStructure.html The function of a protein depends on its tertiary structure. If this is disrupted, the protein is said to be denatured , and it loses its activity. Examples: denatured enzymes lose their catalytic power Denatured antibodies can no longer bind to an antigen. A mutation in the gene encoding a protein is a frequent cause of altered tertiary structure. The mutant versions of proteins may fail to reach their proper destination in the cell and/or be degraded. 

10. REFERENCE: Pamela c, Richard A; 1994; Tertiary structure of globular proteins; In Richard Winters( eds ). Lippincott’s Illustrated reviews: Biochemistry. edition (2 nd ); U.S.A : Lippincott-Raven publishers, pg: 21-22. https://en.wikipedia.org/wiki/Protein_tertiary_structure http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/TertiaryStructure.html

11. Thank you!!