The Pentose Phosphate Pathway.pptx well narated

Biochemistry

1. The Pentose Phosphate Pathway Dr. Oligo Asoka Jacob Senior Pharmacist B.Pharm MHSCM Dr. Oligo Asoka Jacob, B.pharm, MHSCM

2. Introduction Also known as the Hexose Monophosphate (HMP) Shunt. It is an alternative route to the metabolism of glucose. The primary function of this pathway is to: Form NADPH for the synthesis of fatty acids and steroids. Form ribose-5-phosphate for the synthesis of nucleotides and nucleic acids. The primary role of the PPP is anabolic because it involves the formation of NADPH used in anabolic reactions and ribose-5-phosphate used in nucleic acid synthesis. Dr. Oligo Asoka Jacob, B.pharm, MHSCM

3. Introduction The pathway takes place in the cytoplasm of cells in the liver, adrenal cortex, and lactating mammary glands. The pathway has two phases: Irreversible Oxidative phase: NADPH is generated Non-reversible oxidative phase: synthesis of 5-carbon sugars. Dr. Oligo Asoka Jacob, B.pharm, MHSCM

4. PPP Dr. Oligo Asoka Jacob, B.pharm, MHSCM

5. Oxidative phase Dehydrogenation of glucose-6-phosphate to 6-phosphogluconolactone catalyzed by glucose-6-phosphate dehydrogenase. Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate by the enzyme lactonase. Decarboxylation follows with the conversion of 6-phosphogluconate into ribulose-5-phosphate. Dr. Oligo Asoka Jacob, B.pharm, MHSCM

6. Non-oxidative phase Dr. Oligo Asoka Jacob, B.pharm, MHSCM

7. Results Dr. Oligo Asoka Jacob, B.pharm, MHSCM

8. Regulation Dr. Oligo Asoka Jacob, B.pharm, MHSCM

9. Purpose Dr. Oligo Asoka Jacob, B.pharm, MHSCM